Medicine / Anesthesia Flashcards
Pre-Surgical Recs to Diabetic
- NPO for 12 h (delay gastric emptying)
- AM appointments
- Hold oral hypoglycemics day of surgery
- Hold metformin for IV contrast or renal hypoperfusion
- D5 gtt ready
- Hold fast acting insulin, 50% of slow
Diabetic Ketoacidosis
- BG > 500 + metabolic acidosis + ketonemia
Tx:
- IV 0.9% NS
- insulin regular
- Replace K (insulin pushes K inracellularly)
- Bicarb if ph <7
Hypoglycemia
Sx: fatigue, malaise, trembling, cold sweats, confusion, coma
Tx:
- oral glucose if conscious
- if unconscious - IV D5W (up to 500 ml), D50 (up to 50 ml), or glucagon (0.1mg/kg)
Hypertension
- > 2 BP readings >140/90 on > 2 occasions OR BP >200/100
Classification
- Normal <120/80
- Elevated <130/80
- Stage 1 <140/90
- Stage 2 > 140/90
Causes of Hypertension
Essential HTN
- Stress
- Smoking
- Obesity
- EtOH
- Aging
Secondary
- Pheochromocytoma
- Cushing Syndrome
- Renal disease
- Pre-eclampsia
Perioperative Management of Hypertension
- Defer tx if BP > 180/110
- Chronic HTN patients keep taking meds
Alzheimers
- Disease of dementia
- 2/2 accumulation of neurofibrilary tangles and plaques
Parkinsons
- Disease of tremors, rigidity, coordination, and impairment due to decrease in dopamine neurons
Hypertensive Crisis Treatment
- Hospital / Activate EMS
Tx - nitroprusside
- propranolol
- nitroglycerin
- nicardipine
Hypotension
- decrease in arterial pressure > 20%
- bradycardia seen early
- tachycardia seen late
- decrease cardiac output and organ perfusion
Hypotension Treatment
- supine/trendelenburg, elevate legs
- 100% O2
- ASA monitors - NIBP, EKG, pulse ox
IV
- atropine - .01 mg/kg up to 0.5mg (if bradycardic)
- ephedrine 5-10mg q5mins
- phenylephrine 0.1 mg if tachycardic
Treat cause:
- syncope/anxiety
- CAD/MI
- Drugs
- Hypercarbia
- Hypoxia
- decrease volume
Bleeding Disorders
- Von Willebrands
- Hemophilia A and B
- Sickle Cell
Von Willebrands
- Most common bleeding disorder - Factor VIII and vWF deficiency
- Type 1 - AD, 85%, quantitative
- Type 2 - AD, 15%, qualitative
- Type 3 - AR, rare, vWF absent
Tx:
- DDAVP - increases vWF release from endothelium
- Severe - cryoprecipitate (VIII, XII, vWF + fibrinogen) + post operative amicar (inhibits fibrinolysis)
Hemophilia A
- Sex linked deficiency in Factor VIII
- Clinical manifestations when less than 80% factor
- 80% most common hemophilia
Tx:
- mild - DDAVP - increases vWF release from endothelium + VIII
- Severe - cryoprecipitate (VIII, XII, vWF + fibrinogen) + post operative amicar (inhibits fibrinolysis)
Hemophilia B (Christmas Disease)
- Sex linked deficiency in Factor IX
- 20% most common hemophilia
Tx:
- FFP (II, VII, IX, X)
- Severe - IV Proplex (II, VII, IX, X in concentration)
Sickle Cell Anemia
- AR in Hb where deoxygenated Hb polymerizes and precipitates in conditions of decreased O2 or dehydration and results in painful occlusive crises
-Shortened life span of RBCs causes sequestration by spleen -> splenic infarction -> immune compromised to encapsulated organisms (S. pneumo, H influenza)
Tx:
- folic acid increase RBC production
- hydroxyurea drives HbF formation
Transfusion Reactions
- cross agglutination of blood by Ab’s in plasma
- 1/3000 due to clerical errors
Signs/Symptoms
- fever
- hypotension
- sweats/chills
- hives
- anapylaxis/dyspnea
- rigors
- vomiting
- flank pain
- headache
Transfusion Reaction Types
- Acute hemolytic - immune mediated
- Hemolytic - non-immune mediated
- Non-hemolytic
- Allergic reactions - IgE meditated
- Ag contamination
- Delayed reactions
Initial Therapy of Transfusion Reactions
- Maintain BP and renal perfusion
- IVF - NS
- Strict I/Os - monitor urine output
- Nephrology consult early
- Initial diuresis - 40-80 mg lasix - want urine output > 100ml/hr
- Mannitol for osmotic diuresis
- Dialysis - monitor for K from hemolysis
- Benadryl/steroids
- Dialysis
Epilepsy and Seizures
- Epilepsy = 2 or more unprovoked seizures in a lifetime
- General - LOC with/without contractions
- Partial - no LOC
- Status epilepticus - on/off seizures for 30 mins
Seizure Treatment
- control airway
- Supplemental oxygen and monitors
- Activate EMS
- Midazolam - 2mg IV -> 1mg/min IV (.05 mg/kg adults, .025mg/kg peds)
- Glucose check
- Glucose and thiamine prn
Multiple Sclerosis
- Disease resulting in inflammation, demyelination, and degeneration
Symptoms
-vertigo
-nystagmus
-pain, dysesthesia
-optic issues
-heat sensitivity
-Trigeminal neuralgia
Multiple Sclerosis
- Disease resulting in inflammation, demyelination, and degeneration
Symptoms
-vertigo
-nystagmus
-pain, dysesthesia
-optic issues
-heat sensitivity
-fatigue
-weakness
Myasthenia Gravis
Autoimmune disease where acetylcholine receptors attacked resulting in:
- muscular weakness - ocular, face, neck/limbs, respiratory
- fatigue
Beware of drugs that may unmask such as: K, benzos, antibioitcs, muscles relaxants
Pscychiatric Patient Concerns
Drug Interactions
- lower seizure threshold
- increase response to epi
- exaggerated CNS depression
- anticholinergic effects
Liver dysfunction
EKG changes
Serotonin syndrome
Neuroleptic malignant syndrome
MAOIs
- inhibits MAO
- decreases metabolism of serotonin and catecholamines
-caution with ketamine and meperidine
TCAs
- Inhibits reputake of NE/serotonin
- increase response to sympathomimetics, excessive sedation, possible arrhythmias
SSRIs
- Prevents serotonin reuptake
-Caution with MAOIs, tramadol, zofran
Serotonin syndrome:
- tachycardia
- tachypnea
- sweating
- diarrhea
- hyperthermia
- hyperreflexia
Tx:
- lorazepam, cyproheptadine, methylsergide, propranolol
Bipolar Disorder
Mood disorder resulting in episodes of mania and depression
Tx:
- neuroleptics (1st - typical, 2nd - atypical) - inhibit dopamine -> extrapyramidal effects
Neuroleptic Malignant Syndrome -
fever, rigidity, respiratory distress
-Lithium
-Anticonvulsants -valproate, carbamazepine
Concerns in Alcoholic Patient
- Liver dysfunction (decrease in factors II, VII, IX, X, A, D, E, K)
- AST/ALT > 2:1
- decrease in K, Mg, Ph
- EKG anomolies
- DTs: severe aggitation, confusion,
nightmares, tachycardia,
hypertension, sweating
-Tx: benzos
Concerns in Opioid Addicted Patients
- increased anesthetic doses
- use benzos and ketamine
- communicate with pain specialist
Concerns in Alcoholic Patient
- Liver dysfunction (decrease in factors II, VII, IX, X, A, D, E, K)
- AST/ALT > 2:1
- decrease in K, Mg, Ph
- EKG anomalies
- DTs: severe agitation, confusion,
nightmares, tachycardia,
hypertension, sweating
-Tx: benzos
Concerns in Cocaine Abuser
- closely monitor cardiopulmonary system -> high risk of arrhythmia
- no tx within 24 hours of last use
- use caution with local anesthesia
Duchennes’s Muscular Dystrophy
- X linked disorder in dystrophin protein resulting in weakness, waddling gait, kyphosis, and respiratory difficulties
-Avoid depolarizing muscle relaxer and volatile anesthetics - can increase K and increased risk for MH
Marfans Disease
- AD disorder of fibrillin
Signs:
- tall, lanky
- hypermobile joints
- micrognathia
- dislocation of lens
- cardiovascular anomalies - aortic root dilation, aortic regurgitation, MVP, aortic aneurysm)
- Tx: lower heart rate with beta blockers
Rheumatoid Arthritis
- Chronic inflammatory condition via autoimmune attack on synovial lining of joints
- Concerns: cardiac valve abnormalities, sjogrens and salivary flow, pulmonary effusions
- Chronic NSAID use increase risk of platelet dysfunction
- Potential for C-spine and TMJ instablity/dysfunction
Changes in Pregnancy
- increase cardiac output 30-40%
- increase blood volume 25-50%
- increase in clotting factors -> increase risk of DVT
- increase compression of IVC - L lateral position
- increase respiratory difficult, increase in GERD
Dental Treatment in Pregnancy
- 1st trimester - emergency only
- 2nd trimeseter - urgent/semi-elective
- 3rd timester - emergency only
Medications in Pregnancy
- Opioids - IV ok but caution with respiratory depression, hydrocodone ok
- propofol ok
- ambien ok
- ketamine ok
- zofran ok
- tylenol ok
- midazolam ok