Medicine Flashcards
How do you pharmacologically stress a heart?(if can’t walk to do a stress test?)
Dobutamine
Adenosine
Dipyridamole
whatdo in a CABG?
connect LIMA to biggest coronaryarters, and also harvest the saphenous vein located in the legs (dual antiplatelet therapy also required)
Medical management of Angina
Aspiring, Statin, BB, ACE/ARB, DAPT (P2Y12 inhibititor)
what is critical stenosis v obstructive lesions in an artery
critical >70%, occluded is >50%
How do you medically manage CAD?
Aspirin, statin, BB/ARB, DAFT (P2Y12)
Names of 3 PY12 inhibitors for DAPT
clopidogrel, ticagrelor, prasugrel
What statins are used for CAD
high-potency statins like Rosuvastatin, atorvastin
what Beta blockers are used to treat CAD?
metoprolol (controls only HR, B1 antagonist) and carvedilol (controls B1 and a1 antagonist)
ARBS vs ACE inhibitors
do the same thing but ace inhibitors have side effect of angioedema and dry cough
when do you give anti-anginals
when cannot treat CAD and Beta blockers do not relieve symptoms, diff classes:
-nitrates
-dCCBs
-palliative
what are dCCBs used to treat CAD?
Amplodipine (also has antihypertensive effects)
Dihydropyridines are one of the different types of calcium channel blockers; they predominately act on blood vessels with less effect on the heart.
What palliative drug is given for CAD?
Ranolazine (Ranolazine inhibits persistent or late inward sodium current (INa) in heart muscle in a variety of voltage-gated sodium channels. Inhibiting that current leads to reductions in intracellular calcium levels.)
What nitrates are used for CAD?
ISMN and Nitroglycerin Prn
How do you medically manage a STEMI?
–Morphine sulfate 2 to 4 mg IV PRN for severe pain. May repeat dose of 2 to 8 mg at 5 to 15-minute intervals.
–Oxygen via nasal cannula to keep SaO2 > 92%
–Nitroglycerin (NTG) 0.3-0.6 mg SL q5min PRN chest pain. Max: 3 doses within 15 minutes.
–Aspirin. The first tab is 325 (chew), then 81mg QD after that. Avoid enteric coated Aspirin.
–Beta-blocker. Metoprolol tartrate 25mg po q6h
–ACE. Watch BP. May wait to see BB work if concerned about BP or start low dose, e.g. Lisinopril 5mg po BID
–Statin. High-intensity statin for all patients with ACS – atorvastatin 80mg po Qbedtime or rosuvastatin 20-40 mg daily.
–Heparin. For all patients with non-ST elevation ACS, start anticoagulation ASAP after you’ve made the diagnosis. Will start heparin instead of Lovenox. Heparin is easily reversible if needed. 60 U/kg IVB (max 4000 U); 12 U/kg/hr (max 1000 U/hr initially).
what drugs do you give first line with CHF?
ace/aARB and loop diuretic ( furosemide, bumetanide, and torsemide) then only if gets worse give spironolactone
*for an exacerbation of CHF give:
L(lasix)
M(morphine)
N(nitroglycerines)
O (oxygen)
P(position, sit up)
mitral valve stenosis
pathology:
symptoms:
treatment:
Patient: younger (bc pathology due to inflammation from rheumatic heart disease, not calcification like aortic stenosis), atria gets bigger and can lead to afib
Dx: diastolic murmur at the at apex opening snap is specific, rumbling
Tx: balloon valvuloplasty (only murmur for which you can do this bc not calcification)
aortic insufficiency
pathology:
symptoms:
treatment:
path: aotic dissection, infarction, infection
Patient: acute (cardiogenic shock), flash pulmonary edema, chest pain) or chronic (CHF-dyspnea on exertion, crackles, could also have chest pain)
Dx: diastole, rumbling murmur without opening span
Tx: replacement, either urgent or elective (still urgent)
aortic stenosis
pathology:
symptoms:
treatment:
Path: atherosclerosis-> calcium deposition (if bicuspid then makes calcium deposition faster), left ventricle dilates bc regurg, so has big, floppy heart
Patient: old man with atherosclerosis, presenting with chest pain, CHF, and syncope
Dx: systolic, crescendo, decrescendo murmur
Tx: replacement (no valvuloplasty bc it is calcium)
mitral insufficiency
pathology:
symptoms:
treatment:
causes blood to regurg into left atrium so can cause pulmonary edema, CHF, and afib
path: infection, infarction
Pt: acute (cardiogenic shock, pulmonary edema) or chronic (CHF, afib)
Dx: systolic, holosystolic (aka high, pitched and blowing and hear throughout systole)
Tx: replacement
where are aortic v mitral murmers?
aortic=base, or “right sternal border”
mitral= apex, 5th intercostal space, mid-clavicular line
hypertrophic cardiomyopathy murmur
pathology: sacromere mutation
Pt: young athelete, hx of syncopeSOB on exertion
Dx: systolic…more blood makes it better
Tx: avoid dehydration and BB to increase preloadand filling time
mitral valve prolapse
Pathology: congenital
Pt: young woman
Dx: mitral regurgitation that gets better with more blood
Tx: avoid dehydration and BB
how to treat dilated cardiomyopathy?
BB, Ace inhibitors, diuretics
how do you identify and treat hypertrophic obstructive cardiomyopathy (HOCM)?
murmur like AS, but in young athlete bc genetic (DOE, syncope, SCD)
Tx: avoid dehydration (keep heart rate down), BB, CCB
Can surgically treat with EtOH ablation and myectomy
how do you treat concentric hypertrophy?
Tx: diastolic CHF, avoid dehydration and BB or CCB, control HTN
how do you treat restrictive cardiomyopathy?
Path: amyloid, carcoid hemachromatosis (fibrosis and thickened)
Pt: DIA CHF
Amyloid->neuropathy
Sarcoid->pulm disease
Hema->cirrhosis, DM
Tx: diastolic CHF, avoid dehydration and BB or CCB, control HTN
what is the character of pericardial chest pain?
Pleuritic (hurts when you have to take a deep breath in) and positional (hurts when you arch your back and is better when you bend forward)
how do you diagnose pericarditis
EKG, NOT echo (but technically mRI is the best test, but not diagnosistic)
what is thetreatment of pericarditis
NSAIDS+colchicine (be careful of NSAIDS with CKD, thrombocytopenia or peptic ulcer disease also colchicine is dose-limited by diarrhea)