Medicine Flashcards
Delirium vs dementia
Onset: acute/insidious
Course: fluctuating/ gradual deterioration
Awareness: impaired/ often clear until advanced stages
Attention: disturbed/ often good until advanced stages
Memory: poor working memory and immediate recall/ poor short term memory
Delusions: short lived and changing /fixed
Sleep disturbances: fragmented sleep/sleep wake reversal
Chemical sedation
Benzodiazepenes:
Midazolam: 2.5-5mg IV or IM (short acting)
Diazepam: 5-10mg PO/IV
Lorazepam: 1-2mg PO (sedation for 4-6hrs)
Antipsychotics:
Olanzapine: 5-10mg PO/SL; 10mg IM (hypotension)
Haloperidol: 2.5-10mg IV/IM (QT prolongation/dystonia)
Droperidol: 2.5-10mg IV/IM (QT prolongation/dystonia)
Quetiapine: 25-200mg PO
Risperidone: 0.25-2mg PO/SL (orthostatic hypotension)
Chlorpromazine: 100-200mg IV infusion/24hrs
Complications of sedating and restraining patients
- Respiratory depression and pulmonary aspiration
- Sudden cardiac death/ excited delirium
- Hypotension
- Deep venous thrombosis and pulmonary embolus
- Rhabdomyolysis
- Dystonic reactions
- Neuroleptic malignant syndrome
- Anticholinergic effects
- Delirium
- Lactic acidosis
- Lowered seizure threshold
Symptoms and signs of third cranial nerve palsy
- Down and out eye
- Ptosis- weakness of elevator palpebrae
- Diplopia and strabismus
- Dilated fixed pupil and blurred vision- parasympathetic fibres originate from Edinger Westphal subnucleus of 3rd nerve complex
Causes of third nerve dysfunction
Nuclear portion- infarction, hemorrhage, neoplasm, abscess- either side of midbrain tegmentum
Midbrain portion- infarction, neoplasm, abscess or hemorrhage
Subarachnoid portion- posterior communicating artery aneurysm, meningitis/meningeal infiltration, ophthalmologic migraine, mass effect (uncle herniation)
Cavernous sinus portion (lateral wall)- tutor, pituitary infarction, vascular (aneurysm/cv thrombosis/AV fistula), ischemia, inflammatory (Tolosa Hunt syndrome)
Orbital portion- inflammatory (orbital inflammatory pseudotumor), endocrine (thyroid orbitopathy), tumor
Causes of SVC obstruction
- Indwelling SVC catheters- thrombosis, stricture formation, vessel injury and hepatoma
- Lung cancer
- Retrosternal goitre
- Retrosternal tumors: lymphoma, thymoma, dermoid, other malignancies
- Mediastinal lymphadenopathy: breast cancer, other malignancies, granulomatous diseases
- Aortic aneurysm
Management of SVC obstruction
Specific therapy determined by aetiology: Steroids Chemotherapy Radiotherapy Thrombosis- stent, anticoagulation, thrombolytic Surgical resection IV access in the IVC territory **Prepare for: Cardiovascular collapse Central airway obstruction Laryngeal dysfunction Associated respiratory failure
Child Pugh scoring
Variable 1 point 2 points 3 points
Bilirubin
(μmol/L) <34 34-50 >50
Albumin
(g/L) >35 28-35 <28
INR <1.7 1.7-2.3 >2.3
Ascites None Mild Severe(refractory to diuretics)
Encephalopathy None Grade I-II Grade II-IV
CPS A: score 5-6; CPS B: score 7-9; CPS C: score 10-15 (decompensated)
Causes of serotonin syndrome
Antidepressants- MAOIs, SSRIs, SNRIs, TCAs Anticonvulsants- valproate, carbamazepine Opioids- tramadol, buprenorphine Amphetamines Antibiotics- ciprofloxacin, erythromycin Lithium 5HT3 antagonists- ondansetron Metoclopromide
Serotonin syndrome
Triad of CNS dysfunction(altered mentation), autonomic disturbance and neuromuscular hyperactivity
- Venlafaxine is associated with the highest mortality rate among serotonergic agents
- onset usually within 24hours
Differences between serotonin syndrome and NMS
- NMS is a idiosyncratic reaction after prolonged exposure to neuroleptics or after withdrawal of a dopamine receptor agonist.
- NMS usually develops over days or weeks
- NMS usually accompanied by hyperthermia, severe muscle rigidity and rhabdomyolysis (not mydriasis, diarrhoea, hyperreflexia, myoclonus)
- NMS frequently associated with multi-organ failure
SAD-PERSONS score
S- sex: male A- age: <19 or >45years D- depression or hopelessness P- previous attempts/psychiatric care E- excessive drug or alcohol use R- rational thinking loss S- separated/divorced/widowed O- organised or serious attempt N- no social supports S- stated future intent
Causes of hepatic encephalopathy from acute decompensation of chronic liver disease
- sepsis
- spontaneous bacterial peritonitis
- GI haemorrhage
- alcohol (excess or withdrawal)
- drugs (opiates, sedatives, diuretics)
- electrolyte imbalances
- hepatocellular carcinoma
- portal vein thrombosis
- dehydration
Spontaneous bacterial peritonitis - paracentesis finding
Cell count >250/mm3 is diagnostic for SBP