Medications That Cause Obesity

Question 1

Preferred antidepressants with less weight gain

Answer 1

Bupropion
SNRIs
SSRIs other than Paroxetine
Nortryptiline

Question 2

Effects of Trazodone

Answer 2

Low risk

Question 3

Before blaming weight gain on a medication they are taking with weight gain potential, what do you need to do

Answer 3

Get a timeline of onset to determine if initiation of the medication matches onset of weight changes

Question 4

Effects of Atenolol

Answer 4

Weight gain

Question 5

Effects of DPP4 (Januvia/Sitagliptan, Onglyza/Saxagliptan, Tradjenta/Linagliptan…)

Answer 5

Weight negative

Question 6

Effects of sedative hypnotics (Ambien etc.)

Answer 6

Weight gain

Question 7

Effects of Depo

Answer 7

Weight gain

Question 8

The medication with best evidence for use to reverse antipsychotic associated weight gain

Answer 8

Metformin

Question 9

Worst antipsychotic for weight gain

Answer 9

Olanzapine

Question 10

Effects of Sulfonylureas (Glimepiride, Glipizide, Glybyride…)

Answer 10

Weight gain

Question 11

Diabetic meds with more weight gain

Answer 11

Insulin
Sulfonylureas
Thiazolidinediones
Gabapentin
Lyrica

Question 12

Effects of Metformin

Answer 12

Weight negative

Question 13

Effects of Doxepin

Answer 13

Weight gain

Question 14

Effects of Amitriptyline

Answer 14

Heavy weight gain

Question 15

Antidepressants with more weight gain

Answer 15

Paroxetine
Amitryptiline
Doxepin
Mirtazipine

Question 16

Effects of prednisone

Answer 16

Moderate weight gain

Question 17

Effects of carbamazepine

Answer 17

Low risk

Question 18

Effects of diphenhydramine

Answer 18

Weight gain

Question 19

Effects of Respiradone

Answer 19

Weight gain

Question 20

Worst diabetic Med for weight gain

Answer 20

Insulin

Question 21

Effects of Thiazolinediones (Actos/Pioglitazone…)

Answer 21

Weight gain

Question 22

Effects of OCPs

Answer 22

Low risk

Question 23

Effects of Lithium?

Answer 23

Heavy weight gain

Question 24

Effects of some chemotherapeutics

Answer 24

Weight gain

Question 25

Effects of Clonidine

Answer 25

Weight gain

Question 26

Diabetic meds with weight loss

Answer 26

``` Metformin GLP-1 SGLT-2s DPP-4s Acarbose Amylin analogs ```

Question 27

If gain weight from a medication, will stopping it reverse weight gain

Answer 27

Sometimes it won’t. Need extra interventions

Question 28

Effects or Nortriptyline

Answer 28

Low risk

Question 29

Strength of evidence for weight gain related to medication use

Answer 29

Weak. Usually observational studies not RCTs. Studies have contradictory outcomes. No head to heads. Report average which complicates things for meds that may have highly variable effect.

Question 30

Effects of Ziprasidone

Answer 30

Low risk

Question 31

Effects of Metoprolol

Answer 31

Weight gain

Question 32

Effects of Paroxetine

Answer 32

Heavy weight gain

Question 33

Effects of Nexplanon

Answer 33

Low risk

Question 34

Antipsychotics with less weight gain

Answer 34

Aripiprazole Ziprasidone Haloperidol

Question 35

Effects of Valproate

Answer 35

Heavy weight gain

Question 36

Seizures meds with less weight gain

Answer 36

Topiramate Lamotrigine Carbamazepine

Question 37

Effects of Mirtazipine

Answer 37

Heavy weight gain

Question 38

Effects of dextromethorphan (Robitussin)

Answer 38

Can cause weight loss

Question 39

Effects of IUDs

Answer 39

Low risk for hormonal | Lower risk for copper

Question 40

Effects of GLP-1s (Victoza/Liraglutide, Byetta/Bydureon/Exenatide, Trulicity/Dulaglutide ...)

Answer 40

Weight negative

Question 41

Seizure meds with more weight gain

Answer 41

Valproate | Gabapentin

Question 42

Effects of Bupropion

Answer 42

Weight negative

Question 43

Effects of SGLT-2s (Invokana/Canagliflozin, Jardiance/Empagliflozan...)

Answer 43

Weight negative

Question 44

Least obesogenic antipsychoatic

Answer 44

Ziprasidone

Question 45

Effects of SNRIs

Answer 45

Low risk

Question 46

Effects of SSRIs

Answer 46

Low risk weight gain (except for Paroxetine)

Question 47

Effects of Loratidine

Answer 47

Minimal weight gain

Question 48

Effects of Gabapentin

Answer 48

Moderate weight gain

Question 49

Effects of Amlodipine

Answer 49

Weight gain via edema

Question 50

Effects of Lyrica

Answer 50

Worse than Gabapentin

Question 51

Effects of Benzos

Answer 51

Low risk of weight gain

Question 52

Mood stabilizers with more weight gain

Answer 52

Lithium | Valproate

Question 53

Effects of Olanzapine

Answer 53

Heavy weight gain

Question 54

Effects of Lamotrigine

Answer 54

Low risk

Question 55

Effects of opioids

Answer 55

Weight gain

Question 56

Effects of Topiramate

Answer 56

Weight negative

Question 57

Effects of testosterone

Answer 57

Weight negative

Question 58

Effects of Haloperidol

Answer 58

Low risk

Question 59

Effects of Aripiprazole

Answer 59

Low risk

Question 60

Effects of Carvedilol

Answer 60

Weight neutral

Question 61

Effects of HIV retrovirals

Answer 61

Weight gain

Question 62

Preferred mood stabilizers with less weight gain

Answer 62

Lamotrigine | Carbamazepine

Question 63

Effects Quetiapine

Answer 63

Moderate Weight gain

Question 64

If seeing weight gain with a medication that you can’t stop because it’s critical, what next step should you consider

Answer 64

Decreasing dose. Weight gain is often weight dependent

Question 65

Antipsychotics with more weight gain

Answer 65

Olanzapine Clozapine Respiradone Quetiapine

Question 66

Effects of Clozapine

Answer 66

Heavy weight gain