Medications That Cause Obesity Flashcards
Preferred antidepressants with less weight gain
Bupropion
SNRIs
SSRIs other than Paroxetine
Nortryptiline
Effects of Trazodone
Low risk
Before blaming weight gain on a medication they are taking with weight gain potential, what do you need to do
Get a timeline of onset to determine if initiation of the medication matches onset of weight changes
Effects of Atenolol
Weight gain
Effects of DPP4 (Januvia/Sitagliptan, Onglyza/Saxagliptan, Tradjenta/Linagliptan…)
Weight negative
Effects of sedative hypnotics (Ambien etc.)
Weight gain
Effects of Depo
Weight gain
The medication with best evidence for use to reverse antipsychotic associated weight gain
Metformin
Worst antipsychotic for weight gain
Olanzapine
Effects of Sulfonylureas (Glimepiride, Glipizide, Glybyride…)
Weight gain
Diabetic meds with more weight gain
Insulin Sulfonylureas Thiazolidinediones Gabapentin Lyrica
Effects of Metformin
Weight negative
Effects of Doxepin
Weight gain
Effects of Amitriptyline
Heavy weight gain
Antidepressants with more weight gain
Paroxetine
Amitryptiline
Doxepin
Mirtazipine
Effects of prednisone
Moderate weight gain
Effects of carbamazepine
Low risk
Effects of diphenhydramine
Weight gain
Effects of Respiradone
Weight gain
Worst diabetic Med for weight gain
Insulin
Effects of Thiazolinediones (Actos/Pioglitazone…)
Weight gain
Effects of OCPs
Low risk
Effects of Lithium?
Heavy weight gain
Effects of some chemotherapeutics
Weight gain
Effects of Clonidine
Weight gain
Diabetic meds with weight loss
Metformin GLP-1 SGLT-2s DPP-4s Acarbose Amylin analogs
If gain weight from a medication, will stopping it reverse weight gain
Sometimes it won’t. Need extra interventions
Effects or Nortriptyline
Low risk
Strength of evidence for weight gain related to medication use
Weak. Usually observational studies not RCTs. Studies have contradictory outcomes. No head to heads. Report average which complicates things for meds that may have highly variable effect.
Effects of Ziprasidone
Low risk
Effects of Metoprolol
Weight gain
Effects of Paroxetine
Heavy weight gain
Effects of Nexplanon
Low risk
Antipsychotics with less weight gain
Aripiprazole
Ziprasidone
Haloperidol
Effects of Valproate
Heavy weight gain
Seizures meds with less weight gain
Topiramate
Lamotrigine
Carbamazepine
Effects of Mirtazipine
Heavy weight gain
Effects of dextromethorphan (Robitussin)
Can cause weight loss
Effects of IUDs
Low risk for hormonal
Lower risk for copper
Effects of GLP-1s (Victoza/Liraglutide, Byetta/Bydureon/Exenatide, Trulicity/Dulaglutide …)
Weight negative
Seizure meds with more weight gain
Valproate
Gabapentin
Effects of Bupropion
Weight negative
Effects of SGLT-2s (Invokana/Canagliflozin, Jardiance/Empagliflozan…)
Weight negative
Least obesogenic antipsychoatic
Ziprasidone
Effects of SNRIs
Low risk
Effects of SSRIs
Low risk weight gain (except for Paroxetine)
Effects of Loratidine
Minimal weight gain
Effects of Gabapentin
Moderate weight gain
Effects of Amlodipine
Weight gain via edema
Effects of Lyrica
Worse than Gabapentin
Effects of Benzos
Low risk of weight gain
Mood stabilizers with more weight gain
Lithium
Valproate
Effects of Olanzapine
Heavy weight gain
Effects of Lamotrigine
Low risk
Effects of opioids
Weight gain
Effects of Topiramate
Weight negative
Effects of testosterone
Weight negative
Effects of Haloperidol
Low risk
Effects of Aripiprazole
Low risk
Effects of Carvedilol
Weight neutral
Effects of HIV retrovirals
Weight gain
Preferred mood stabilizers with less weight gain
Lamotrigine
Carbamazepine
Effects Quetiapine
Moderate Weight gain
If seeing weight gain with a medication that you can’t stop because it’s critical, what next step should you consider
Decreasing dose. Weight gain is often weight dependent
Antipsychotics with more weight gain
Olanzapine
Clozapine
Respiradone
Quetiapine
Effects of Clozapine
Heavy weight gain