Medications Flashcards
Cyclosporine toxicity
Mech: blocks IL-2 Renal HTN Disc edema Gingival hyperplasia
Alternative to durezol for tx of hypotony
Ibopamine- nonselective dopaminergic medication that increases aqueous production approximately four-fold. (Only available in Europe)
- Increases IOP by 2 mmHg for approximately 8 hours.
Gancyclovir Toxicity
Myelosuppression (neutropenia, thrombocytopenia)
Foscarnet Toxicity
Nephrotoxic
Anti-cytokine drugs
ex: etanercept, infliximab
demyelinating disease and optic neuritis
Cyclophosphamide
hemorrhagic cystitis (po > IV), myelosuppression (less commonly bladder ca and sterility)
Prevent with hydration
Cidofovir
hypotony (CB atrophy)
uveitis (1 wk p last infusion) & IMMUNE RECOVERY UVEITIS
renal
Reduce side FX c probenecid and hydration
MTX mechanism
Inhibits DHFR –> prevents DNA replication
Anti Inflammatory effects through release of adenosine
Tox: BM suppression, hepatotoxic and renal tox
Side FX: GI upset, stomatitis –> check CBC/LFTs monthly
TNF inhibitor
Demyelinating dz
Name examples of
a. IL-2 modulators
b. alkylating agents
c. Cytotoxic antimetabolite
a. cyclosporine, FK-507
b. chlorambucil, cyclophosphamide
c. MTX, azathioprine
Intermediate uveitis tx and c/I
Most common: cyclosporine, MTX
Infliximab c/i in pts c MS b/c may worsen dz
Infliximab side FX
drug-induced lupus, vascular thromboses, CHF, demyelinating dz Low dose of MTX may prevent development of drug-induced lupus.
Azathioprine mechanism and side FX
Purine analog –> 6 MP
Leukopenia, hepatotoxic, ? inc risk of heme malig
Mycophenolate
GI upset, leukopenia and RBc aplasia, ?inc risk of heme ca, PML
Polyenes
Ampho, natamycin
Bind ergosterol
