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CPHON > Medications > Flashcards

Medications Flashcards

1
Q

What 3 things do you need to know about the administration of anthracyclines?

A

1) They’re vesicants.
2) Cumulative lifetime maximum dose
3) Reduce dose if pt gets radiation

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2
Q

What do you monitor for with anthracyclines?

A
  • EKG/Echo

* Changes in urine/tears color

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3
Q

Side effects of anthracyclines?

A
  • GI; mucositis
  • Cardiac
  • Early/low nadir
  • Alopecia
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4
Q

Emetic potential of anthracyclines?

A

High

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5
Q

What is the cardiac protectant drug for anthracyclines and how soon do you administer it prior to giving the anthracycline?

A

Dexrozoxane (30 minutes prior)

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6
Q

What are 2 things to know about the administration of Cisplatin?

A

2) IV fluids with magnesium and mannitol

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7
Q

What 4 things do you monitor with Cisplatin?

A
  1. Check UOP q1-2 hours.
  2. Hearing tests
  3. Creatinine
  4. Creatinine clearance or iothalamate tests (iothalamate coming out of favor)
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8
Q

What organs are affected most by Cisplatin?

A

Kidneys and ears (high-pitched hearing loss)

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9
Q

What is the emetic potential of Cisplatin?

A

VERY HIGH!!!

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10
Q

What PRN medications might you give with Cisplatin?

A

Mannitol and Lasix PRN if UOP falls

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11
Q

What are 2 administration things to know about cyclophosphamide (cytoxan)?

A
  1. Always given with IVF

2. Mesna for higher doses

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12
Q

What do you monitor for with cytox?

A

Dip urine q void

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13
Q

What are side effects of cytox?

A
  • Hemorrhagic cystitis
  • Cardiac if high dose
  • Kidneys
  • SIADH
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14
Q

What is the emetic potential of cytox?

A

Moderate

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15
Q

What is hemorrhagic cystitis?

A

A biproduct of cytox (acrolein) irritates the bladder wall

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16
Q

What secondary cancer does cyclophosphamide put you at risk for?

A

Bladder cancer

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17
Q

What do you need to know about the administration of cytarabine (ARA-C)?

A

It has variable doses and variable forms.

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18
Q

What other medication is given with ARA-C?

A

Eye drops:
• Prophylactic NS with high dose
• Tx steroid drops if conjunctivitis

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19
Q

What are the side effects of cytarabine?

A
  • Chemical conjunctivitis
  • High fevers/flu symptoms
  • Hand/foot syndrome
  • Neuro toxicities (seizures, fine motor)
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20
Q

What is the emetic potential of ARA-C?

A
  • Low to moderate

* High if given IT (give zofran)

21
Q

Patients that get ARA-C are at increased risk for getting ___, because ____. Therefore AML patients get ____ when they spike a fever.

A
  1. Strep viridins
  2. strep V lives in the gut wall and ARA-C messes with the gut wall
  3. Cefepime
22
Q

What do you need to know about the administration/preparation of etoposide?

A
  • It needs minimal dilution for stability.

* Undiluted it’s very unstable.

23
Q

What do you need to monitor for with etoposide?

A

Hypotension: check BP before and mid-dose and slow the infusion if low BP.

24
Q

What is the emetic potential of etoposide?

A

Low to moderate

25
Q

What secondary malignancy can result from etoposide treatment?

A

AML

26
Q

What are 2 things to know about the administration of ifosfamide?

A
  • IVF

* Always with mesna

27
Q

What do you monitor for with ifosfamide?

A

Dip urine Q void.

28
Q

What are side effects of ifosfamide?

A
  • Hemorrhagic cystitis
  • Cardiac if high dose
  • Kidneys
29
Q

What is the emetic potential of ifosfamide?

A

Moderate

30
Q

What other kidney thing can ifosfamide cause?

A

Fanconi Renal Syndrome (pee a lot, electrolytes off)

31
Q

What chemotherapies are given intra-thecally?

A

ARA-C, HCT, and MTX

32
Q

How is IT chemo dosed?

A

By age

33
Q

What are the platelet thresholds for IT chemo?

A

PLTs>10 (ommaya)

PLTs>20 (LP)

34
Q

What administration thing do you need to know regarding IT chemo?

A

Need to lie flat to avoid headache

35
Q

What are side effects of IT chemo?

A
  • Headache
  • Neurotoxicity
  • Cognitive development
  • Seizure
36
Q

What is the emetic potential of IT chemo?

A
  • MTX/HCT: low

* ARA-C: high

37
Q

What 3 things do you need to know about methotrexate?

A
  1. Many routes and doses

2. IV give with bicarbonate fluids

38
Q

What 4 things do you monitor with methotrexate?

A
  1. Urine pH

2. MTX level must be

39
Q

What are the side effects of MTX?

A

Liver, kidneys, GI/mucositis, rash, neuro toxicity/seizure

40
Q

What is the emetic potential of MTX?

A

Moderate to high depending on the dose

41
Q

What med is held while receiving MTX?

A

Bactrim

42
Q

What supportive med do you receive while on MTX?

A

Leucovorin

43
Q

What is one administration consideration for oral steroids?

A

They taste bad!

44
Q

What do you need to monitor with steroids? (Name 3)

A
  1. BPs
  2. Glucose
  3. Appetite/moods
45
Q

What are three side effects of steroids?

A

Bone density, cushingd syndrome, infection/healing

46
Q

What is the emetic potential for steroids?

A

None

47
Q

What are steroids’ affect on counts?

A

None

48
Q

What do you need to know about administering thiotepa?

A

Bath/shower and linen change QID, care with skin, no lotion/ careful with adhesives

49
Q

What are the side effects of thiotepa?

A

Skin, GI

CPHON (1 decks)

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