Medications Flashcards

0
Q

The first drug given in an acute MI

A

Oxygen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Three classifications of drugs used in treatment of angina

A

Nitrates, beta blockers, oxygen, aspirin, calcium channel blocker’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

This drug is given rapidly IVP to treat SVT

A

Adenosine or Adenocard

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Potent after load and preload reducing agent

A

Nitropressside aka nitride

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is digoxin toxicity

A

Arrhythmias, nausea, anorexia, visual disturbances

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are side effects of lidocaine

A

Slurred speech, confusion, Muscle twitching, decreased hearing and seizures are side effects of this medication.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is protamine sulfate

A

Antagonizes the action of heparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Three drugs which may be used during acute phase of pulmonary edema

A

What is 02, morphine, nitroglycerin, Lasix and nitropresside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Used in treatment of CHF, may prevent adverse remodeling of the heart

A

What are ACE/ARB’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Side effects may include widening of QRS by 50%, prolongation of QT interval, heart block, torsades, lupus like syndrome in long-term therapy, hypotension

A

Procainamide, Side effects of

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Can be given in the place of epinephrine for the first or second dose

A

vasopressin

40 units IV push for one dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the side effects of amiodarone

A

Hypotension, bradycardia, prolongation of QT interval

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Atropine

0.5 mg IV q 3-5 mins

A

Parasympathetic drug use in sympathetic sinus bradycardia.
Not effective in Mobitz type II (infra-nodal block)
Avoid and hypothermic bradycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Dopamine infusion

1 - 20 mcg/kg/min

A

Preferred catecholamine for bradycardias, in which, atropine is ineffective or contraindicated.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Tachycardia, hypertension, extravasation (tissue narcoses), excessive vasoconstriction, exacerbate superventricular and ventricular arrhythmias are side effects of what medication?

A

Dopamine effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Epinephrine

1:10,000 & 1:1,000

A

Used in cardiac arrest, symptomatic bradycardia, severe hypotension, anaphylaxis
Natural catecholamine with both alpha and beta adrenergic agonist activity
Alpha adrenergic effects:
-increase my cardio and three bloodflow
– Increased peripheral vasoconstriction and improves coronary artery perfusion pressure
-produces renal vasoconstriction causing decreased renal bloodflow and urine output

Arrest: 1 mg of 1:10,000 solution q 3 - 5 minutes IVP
Continuous infusion: 2 - 10 mcg/min titrate to affect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

May precipitate or exacerbate myocardial ischemia, hypotension, and can induce ventricular ectopy, especially in patients receiving digoxin.

A

Side effects potentially from epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Adenosine
6 mg IVP slam followed by 20 mL bolus
Repeat in 1 to 2 minutes with 12 mg IVP if needed

A

First dose for most forms of stable narrow complex SVT
Maybe considered for unstable narrow complex reentry tachy

*is not used to convert afib, aflutter or VT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

This medication may cause transient side effects that include Flushing, chest pain or tightness, 6-15 seconds of asystole, bradycardia or ventricular ectopy, bronchoconstriction if asthma…

A

What is adenosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Digoxin (cardiac glycoside)

Loading dose 4-6 mcg/kg over 5 min

A

Used in stable patients with slow ventricular response in afib/aflutter, alternative drug for reentry SVT.
Positive inotrope with a slow onset of action
Toxic to therapeutic ratios are narrow especially in hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Class Ia Antiarrhythmics:
Quinidine
Procainamide
Disopyramide

A

Moderate fast sodium channel blockade.

Reduce conductivity and prolong repolarization & the action potential (longer QTs).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Procainamide

A

Arrhythmia suppression, rhythm converted

Class Ia antiarrhythmic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q
Class Ib antiarrhythmic:
Lidocaine a.k.a. Xylocaine, Zingo
Mexiletine
Phenytoin a.k.a. dilantin
Tocainide
A

Mild– Fast sodium channel blockade
Slows AV conduction, local anesthetic
Toxic to therapeutic balance delicate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Lidocaine
Cardiac arrest from the VF/VT: 1-1.5 mg/kg, Max 3 mg/kg
repeat 0.5–0.75 MG/KG in 5-10 minutes

A

Alternative to amiodarone in cardiac arrest VT/VF.
Stable monomorphic VT with preserved ventricular function.
Stable polymorphic VT with normal baseline QT interval, and preserved LV function when ischemia is treated and electrolyte balance is corrected.
Stable polymorphic VT with baseline QT interval prolongation in torsades suspected.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
``` Class Ic antiarrhythmics: flecainide Propafenone Moricizine Encainide ```
Markedly reduces conduction; use only for refractory arrhythmias and are pro-arhythmic
25
Class I I antiarrhythmics: Beta blockers – olol
Given for myocardial infarction's and unstable angina Second line agent after adenosine Adjunctive agent with fibrinolytic therapy Beta 1 decreases heart rate, contractibility and conductivity. beta 2 can produce bronchospasms, vasoconstriction
26
Propranolol
Class II Antiarrhythmic Beta blocker Noncardiac selective for SVT
27
Labetalol
Class II Antiarrhythmic Cardio selective beta blocker Used in treatment of acute stroke, hypertensive emergencies and acute aortic dissection
28
Metoprolol
Class II Antiarrhythmic | Cardio selective
29
Sotalol a.k.a. Betapace, Sorine
Class II Antiarrhythmic Nonselective beta blocker Treatment of supraventricular arrhythmias and ventricular arrhythmias without structural heart disease
30
This medication may cause bradycardia, hypertension and arrhythmias (torsades), avoided in patients with poor perfusion due to significant negative inotropic effects. May become toxic with patients with renal impairment.
Side effects of Sotalol
31
Side effects of this class of drug include; hypotension, bradycardia; AV conduction delay,bronchospasm, and can cause severe hypotensionwhen given with calcium channels blockers.
Beta blockers side effects
32
Class I I I antiarrhythmics: Amiodarone Ibutilide Dofetilide
Potassium channel blockers. | Prolongs action potential, prolongs refractory period, Decreases AV conduction.
33
Amiodarone | Arrest dose: 300 mg IVP
Used for treatment of life-threatening recurrent ventricular arrhythmias,when they have not responded to other antiarrhythmics. Half-life of 15 to 40 days IV
34
The side effects of his medication are hypotension, bradycardia, pulmonary fibrosis, liver dysfunction & many drug interactions
Side effects of amiodarone
35
Side effects of this medication are that it can cause torsades. Monitor patient for 4 to 6 hours after administration
Side effects of ibutilide
36
Ibutilide
Class III antiarrhythmic Treatment of supraventricular arrhythmias, including atrial fibrillation and atrial flutter when duration is less than or equal to 48 hours.
37
Class IV antiarrhythmics: Diltiazem a.k.a. Cardizem Verapamil
Calcium channel blocker's | Slow conduction and increase refractory in AV node
38
Precautions of this class of medications are do not use for wide QRS tachycardias of uncertain origin, avoid inpatients with accessory pathway WPW, sick sinus syndrome, second or third degree heart block. Side effects are hypotension
Calcium channel blocker's like cardizem, verapamil
39
Diltiazem
``` Calcium channel blocker; class IV antiarrhythmics Controlled ventricular rate in a fib/a flutter. May terminate reentry arrhythmias and require AV nodal conduction for the continuation. Used after adenosine to treat refractory reentry SVT in patients with narrow QRS complexes and adequate blood pressure. ```
40
Why use vasoactive medications
Stabilize hemodynamics Avert cardiovascular collapse Restore perfusing rhythm Improve cardiac output and organ perfusion
41
adrenergic receptors
Regulate cardiac, vascular, bronchiolar, and gastrointestinal smooth muscle tone. Major classes are: Alpha adrenergic receptors Alpha one and two Beta-adrenergic receptors beta one and two Dopaminergic receptors
42
Alpha adrenergic receptors do what?
Predominately regulate vascular smooth muscle tone. When in antagonist stimulate receptors, vasoconstriction occurs. Aka catecholamines: norepinephrine (most potent) Epinephrine(2nd most potent) Isoproterenol Phenylephrine
43
Beta adrenergic receptors
Beta-1 adrenergic receptors are the adrenergic receptors of the heart. -concentrate in the sinus node and ventricles, beta-1 receptors are excitatory. Ex. Increase rate & strength of contractibility. Beta-2 adrenergic receptors are the beta-adrenergic receptors of the rest of the body. -leads to vasodilation
44
Dopaminergic receptors
Located in the smooth muscle cells in the cerebral, coronary, renal, and splenchic vascular bed. Also present in proximal renal tubular cells and in the pituitary gland. Activation result in vasodilation of the above vascular beds.
45
Vasopressors do what?
Increased blood pressure
46
Positive inotropes cause what?
Increased contractility
47
Negative inotropes cause what?
Decrease contractibility
48
Side effects of this medication are: bradycardia, fullness of head, headache, hypertension, tingling of extremities, tremulousness, ventricular extrasystole, and V tachycardia (short paroxysm), vertigo.
Phenylephrine, Side effects of
49
Phenylephrine
Sympathomimetic similar to epinephrine. Acts primarily on alpha-adrenergic receptors. Renal vasoconstriction will occur. A potent, long lasting vasoconstrictor unique in that it slows heart rate, increases stroke volume and does not induce any change in the rhythm of the pulse.
50
Norepinephrine a.k.a. Levophed
Naturally occurring catecholamine chemical similar to epinephrine. Causing arterial and venous vasoconstriction, increases myocardial contractibility Potent vasoconstrictor and inotropic agents treats severe hypotension SBP less than 70, with a low total peripheral resistance.last resort for management of cardiogenic shock.
51
The side effects of this medication are: contra indicated for hypotension caused by hypovolemia, Monitor blood pressure closely during therapy, may increase myocardial oxygen requirements, May precipitate arrhythmias, ischemic necrosis and sloughing due to infiltration.
Side effects of norepinephrine
52
Vasopressin
Non-adrenergic, naturally occurring hormone, also known as antidiuretic hormone. Use for pulseless arrest (PEA), Has shown to increase coronary perfusion pressure, vital organ bloodflow, cerebral oxygen delivery.
53
Side effects of this medication are: pallor of skin,nausea, intestinal cramps, urge to defecate,bronchial constriction, and a uterine contractions in women, May cause serious myocardial ischemia, vascular dysrhythmia
Vasopressin, side effects of
54
Dobutamine
Synthetic catecholamine; adrenergic stimulant Stimulates beta-1 and alpha-1 adrenergic receptors Stimulates alpha-1 adrenergic receptors that is balanced by beta-2 stimulation -vasoconstriction balanced by vasodilation. Variable affects the blood pressure Treatment of patients with severe systolic heart failure or who cannot tolerate vasodilation
55
Nitropressside aka nitride
Potent - direct peripheral vasodilator that affects both venous and arterial smooth muscle. Reduces preload and afterload. Immediate onset of action, effects cease within minutes of stopping Useful for treatment of severe heart failure and hypertensive emergencies
57
Side effects of this medication include: hypotension, headache, nausea, giddiness,faintness, or syncope, tachycardia and paradoxical bradycardia, hypoxemia from increase in ventilation perfusion mismatch.
Nitrates, side effects of
59
Side effects of this medication are: tachy arrhythmias,fluctuations in BP, headaches, tremor, hypokalemia, and nausea
Dobutamine, Side effects of
60
Side effects of this medication are: hypotension, carbon dioxide retention, and thiocyanate toxicity. Induced hypotension candy severe; it may precipitate myocardial ischemia, infarction, or stroke.
Nitroprusside a.k.a. nitride, Side effects of
61
Ace inhibitor
Inhibits formation of converting enzyme, thus formation of aldosterone. Examples: Captopril, Enalapril, lisinopril SE: Monitor for hyper kalemia and decreased renal function. Cough is a side effect
62
nitrates
Vasodilator, bind to specific vascular receptors that relax and dilate vascular smooth muscle. Dilate large coronary conduit arteries, antagonizes Vaso spasms, and increases coronary collateral bloodflow to ischemic myocardium. Indications: angina pectoris, acute pulmonary edema and CHF, acute MI
63
This medication is contraindicated with RV infarction, SBP less than 90, severe bradycardia or extreme tachycardia.
Precautions of nitrates