Medications Flashcards
Which medication is used most for bipolar disorder? classification action contraindications daily dosage indications unlabeled uses
Lithium carbonate which is a mood stabilizer. Classification: anti manic
Action: modulate the effects of neurotransmitters (norepinephrine, serotonin, dopamine, glutamate, GABA)
Contraindications - hypersensitivity, cardiac or renal disease, dehydration, sodium depletion
Daily dosage: acute mania 1800-2400 mg (1.0-1.5 mEq/L)
maintenance 900-1200mg (0.6-1.2 mEq/L)
Indications: prevention and treatment of manic episodes of bipolar disorder
Unlabeled uses: neutropenia, cluster headaches (prophylaxis), alcohol dependence, bulimia, postpardum affective psychosis, corticosteroid-induced psychosis
Anticonvulsant Carbamazepine (tegretol) indications unlabeled uses action contraindications daily dosage
indications: epilepsy, trigerminal neuralgia
unlabeled uses: bipolar disorder, resistant schizophrenia, management of alcohol withdrawal, restless leg syndrome, postherpetic neuralgia
action - treatment in bipolar disorder unclear
contraindications - hypersensitivity, with MAOIs, lactation
daily dosage 200-1600 mg
caution in elderly, liver/renal/cardiac disease, pregnancy
anticonvulsant clonazepam indications unlabeled uses action contraindications daily dosage
indications - petit mal akinetic, myoclonic seizures, panic disorder
unlabeled uses-acute manic disorders, uncontrolled leg movements during sleep, neuralgias
action - treatment in bipolar disorder unclear
contraindications-hypersensitivity, glaucoma, liver disease, lactation
daily dosage 0.5-20mg
anticonvulsant valproic acid (depakene; depakote) indications action contraindications daily dosage
indications-epilepsy, manic episodes, migraine prophylaxis, adjunct therapy in schizophrenia
action- bipolar treatment unclear
contraindications - hypersensitivity, liver disease
caution with lactation
daily dosage 5mg/kg to 60mg/kg
50-150 mcg/mL
anticonvulsant lamotrigine (lamictal) indications unlabeled uses action contraindications daily dosage
indications-epilepsy unlabeled uses-bipolar disease action-bipolar treatment unclear contraindications-hypersensitivity caution in renal and hepatic insufficiency, pregnancy, lactation, and children <16 daily dosage 100-200mg
anticonvulsant topiramate (topamax) indications unlabeled uses action contraindications daily dosage
indications-epilepsy, migraine prophylaxis
unlabeled uses-bipolar disorder, cluster headaches, bulimia, binge eating disorder, weight loss in obesity
action - bipolar treatment unclear
contraindications - hypersensitivity
daily dosage 50-400 mg
anticonvulsant oxcarbazepine (trileptal) indications unlabeled uses action contraindications daily dosage
indications-epilepsy unlabeled uses-bipolar disorder, diabetic neuropathy, neuralgia action - bipolar treatment unknown contraindications - hypersensitivity daily dosage 600-2400mg
calcium channel blocker verapamil (calan, isoptin) indications unlabeled uses action contraindications daily dosage
indications-angina, arrthymias, hypertension
unlabeled uses-bipolar mania, migraine headache prophylaxis
action-bipolar treatment unknown
contraindications-hypersensitivity, severe left ventricular dysfunction, heart block, hypotension, cardiogenic shock, congestive heart failure
caution in liver or renal disease, cardiomyopathy, intracranial pressure, elderly patients, pregnant, lactation
daily dosage 80-320mg
antipsychotics olanzapine (zyprexa) indications unlabeled uses action contraindications daily dosage
indications-schizophrenia, acute manic disorders, management of bipolar disorder, agitation associated w/ schizophrenia or mania
unlabeled uses- obsessive compulsive disorder
action - ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage 10-20mg
antipsychotic olanzapine and fluoxetine (symbyax) indications action contraindications daily dosage
indications-for treatment of depressive episodes associated with bipolar disorder
action-ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage 6/25-12/50 mg
antipsychotic aripiprazole (abilify) indications action contraindications daily dosage
indications-bipolar mania, schizophrenia
action-ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage 10-30mg
antipsychotic Chlorpromazine indications unlabeled uses action contraindications daily dosage
indications - bipolar mania, schizophrenia, emesis/hiccoughs, acute intermittent porphyria, preoperative apprehension
unlabeled uses-migraine headaches
action-ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage75-400mg
Antipsychotic quetiapine (seroquel) indications unlabeled uses action contraindications daily dosage
indications - schizophrenia, acute manic disorders
action-ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage 100-800mg
antipsychotic risperidone (risperdal) indications unlabeled uses action contraindications daily dosage
indications - bipolar mania, schizophrenia
unlabeled uses - severe behavioral problems in children, behavioral problems associated with autism, obsessive compulsive disorder
action
action-ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage 1-6mg
antipsychotic Ziprasidone (geodon) indications action contraindications daily dosage
indications-bipolar mania, schizophrenia, acute agitation in schizophrenia
action-ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage 40-160mg
antipsychotic Asenapine (saphris) indications action contraindications daily dosage
indications-schizophrenia, bipolar mania
action-ALL antipsychotics: efficacy in schizophrenia is achieved through a combo of dopamine and serotonin type 2 (5HT2) antagonism; mechanism of action in the treatment of mania is unknown
contraindications - ALL antipsychotics: contraindicated in hypersensitivity and during lactation; caution with hepatic or cardiovascular disease, history of seizures, comatose or other CNS-depression
daily dosage 10-20mg
side effects of anti manic medication - lithium bicarbonate
drowsiness, dizziness, headache, dry mouth, GI upset, nausea/vomiting, fine hand tremors, hypotension, arrhythmias, pulse irregularities, polyuria, dehydration, weight gain
side effect os anticonvulsants: clonazepam (klonopin), carbamazeprine (tegretol), valproic acid (depakote, depakene), lamotrigine (lamictal), topiramate (topamax), oxcarbazepine (trileptal)
nausea/vomiting, drowsiness, dizziness, blood dyscrasias, prolonged bleeding time (w/valproic acid), risk of severe rash (w/ lamotrigine), decreased efficacy with oral contraceptives (w/topiramate), risk of suicide w/ all anti epileptic drugs
side effects of calcium channel blocks: verapamil (calan, isoptin)
drowsiness, dizziness, hypotension, bradycardia, nausea, constipation
side effects of antipsychotics: ariprazole (ability), asenapine (saphris), chlorpromazine olanzapine (zyprexa), quetiapine (seroquel), risperidone (risperdal), ziprasidone (geodon)
drowsiness, dizziness, dry mouth, constipation, increased appetite, weight gain, ECG changes, extrapyramidal symptoms, hyperglycemia, diabetes
bipolar disorder have possible excess norepinephrine and dopamine. Also, low serotonin levels. True or false?
True
