Medications

Question 1

Typical antipsychotic agents (first generation, conventional)
chlorpromazine
daily dosage?

Answer 1

40-400 mg

Question 2

Typical antipsychotic agents (first generation, conventional)
fluphenazine
daily dosage?

Answer 2

2.5-10mg

Question 3

Typical antipsychotic agents (first generation, conventional)
haloperidol
daily dosage?

Answer 3

1-100 mg

Question 4

Typical antipsychotic agents (first generation, conventional)
loxapine
daily dosage?

Answer 4

20-250 mg

Question 5

Typical antipsychotic agents (first generation, conventional)
perphenazine
daily dosage?

Answer 5

12-64 mg

Question 6

Typical antipsychotic agents (first generation, conventional)
pimozide
daily dosage?

Answer 6

1-10 mg

Question 7

Typical antipsychotic agents (first generation, conventional)
prochlorperazine
daily dosage?

Answer 7

15-150 mg

Question 8

Typical antipsychotic agents (first generation, conventional)
thioridazine
daily dosage?

Answer 8

150-800mg

Question 9

Typical antipsychotic agents (first generation, conventional)
thiothixene (navane)
daily dosage?

Answer 9

4-40mg

Question 10

Atypical antipsychotic agents (2nd generation, novel)
aripiprazole (abilify)
daily dosage?

Answer 10

10-30mg

Question 11

Atypical antipsychotic agents (2nd generation, novel)
asenapine (saphris)
daily dosage?

Answer 11

10-20mg

Question 12

Atypical antipsychotic agents (2nd generation, novel)
clozapine (clozaril)
daily dosage?

Answer 12

300-900 mg

Question 13

Atypical antipsychotic agents (2nd generation, novel)
iloperidone (fanapt)
daily dosage?

Answer 13

12-24 mg

Question 14

Atypical antipsychotic agents (2nd generation, novel)
lurasidone (latuda)
daily dosage?

Answer 14

40-80mg

Question 15

Atypical antipsychotic agents (2nd generation, novel)
olanzapine (zyprexa)
daily dosage?

Answer 15

5-20mg

Question 16

Atypical antipsychotic agents (2nd generation, novel)
paliperidone (invega)
daily dosage?

Answer 16

6-12mg

Question 17

Atypical antipsychotic agents (2nd generation, novel)
quetiapine (seroquel)
daily dosage?

Answer 17

300-400mg

Question 18

Atypical antipsychotic agents (2nd generation, novel)
risperidone (risperdal)
daily dosage?

Answer 18

4-8mg

Question 19

Atypical antipsychotic agents (2nd generation, novel)
ziprasidone (geodon)
daily dosage?

Answer 19

40-160mg

Question 20

Blockage of what receptors is thought to be responsible for controlling positive symptoms of schizophrenia

Answer 20

dopamine

dopamine blockage also results in extrapyramidal symptoms

Question 21

extrapyramidal symptoms include pseudoparkinsonism, akinesia, akathisia, dystonia, oculogyric crisis. Describe each.

Answer 21

pseudoparkinsonism - tremor, shuffling, gait, drooling, rigidity (symptoms appear 1-5 days following antipsychotic med)
akinesia - muscular weakness
akathisia - continuous restlessness and fidgeting (occur 50-60 days following initiation of therapy)
Dystonia - involuntary muscular movements of (spasm) face, arms, legs, and neck (mostly in men 25 and younger)
Oculogyric crisis - uncontrolled rolling back of eyes

Question 22

2 typical antipsychotic agents with very high risk of EPS

Answer 22

fluphenazine and haloperidol (haldol)

Question 23

All atypicals antipsychotic agents have a rate of what for EPS

Answer 23

1

Question 24

Which atypical antipsychotic agent has the highest rate of anti-cholinergic (drug that blocks the action of the neurotransmitter acetylcholine in the brain), weight gain and sedation?

Answer 24

clozapine (clozaril)

Question 25

which atypical has the highest rate of weight gain?

Answer 25

olanzapine (zyprexa)

Question 26

antiparkinsonian agents used to treat extrapyramidal side effect of antipsychotic drugs. which drugs are these? chemical class? daily dosages?

Answer 26

Anticholinergics: benzotropine (cogentin)
1-8mg, biperiden (akineton) 2-6mg, trihexyphenidyl 1-15mg
Antihistamines: diphenhydramine (benadryl) 25-200mg
Dopaminergic agonists: amantadine 200-300 mg

Question 27

common side effects for antipsychotics

Answer 27

anticholinergic effects: dry mouth, blurred vision, constipation, urinary retention; nausea; GI upset; skin rash; sedation; orthostatic hypotension; photosensitivity (wear sunblock); hormonal effects; ECG changes; reduction in seizure threshold; agranulocytosis (more common in typical than atypical w/exception of clozapine); hyper salivation; extrapyramidal symptoms; tardive dyskinesia; neuroleptic malignant syndrome (NMS) (more common in typical)