Medications

Question 1

Which SSRI does not affect RLS/PLMD

Answer 1

Bupropion

Question 2

Methylphenidate

Answer 2

Blocks dopamine reuptake and enhances release of dopamine and norepinephrine
improve alertness, psychomotor performance
increases sleep latency

Question 3

Increase NREM stage 3 and 4

Answer 3

adenosine agonists, alcohol (acute ingestion), antihistamines, apomorphine, benztropine, carbamazepine, clonidine, Il-1, lithium, 1-tryptophan, mirtazapine, phenytoin, ritanserin, trazodone, TCA, trihexylphenidyl

Question 4

Decrease NREM stage 3 and 4

Answer 4

adenosine antagonists, alcohol (withdrawal), barbiturates, benzodiazepines, beta adrenergic blockers, caffeine (during 1st half of sleep), corticosteroids, levodopa, methyldopa, prostaglandin E, SSRI, selegiline, stimulants

Question 5

Risperdone

Answer 5

decrease awakenings, increase in stage 3, 4, decrease in REM sleep, no change in RL
can worsen PLM

Question 5

Do not change rem latency

Answer 5

Mirtazapine

Nefadodone