Medical & Surgical Conditions of Pregnancy Flashcards
who is at risk of developing a pregnancy related HTN disorder
what are the fetal complications of HTN during pregnancy
affect 5-10% of pregnancies
- a major player in maternal morbidity and mortality
- this can include those with HTN getting pregnant & those who get HTN while pregnant
RIsk Factors: who is at risk for HTN during pregnancy
- first child (primiparity)
- prior pre-eclampsia
- Chronic HTN
- histor of thrombophilia
- multiple fetuses (multiples)
- IVF
- family history
- DM
- SLE
- AMA (advanced materal age)
- obesity
- AA race
Fetal Outcomes
- IUFD
- IUGR
- preterm delivery
when there is HTn during pregnancy, there is no way for the uterus to regulate the blood flow its receiving : thus if there is HTN; constricted vessel, decreased blood flow to the uterus and the uterus has no compensatory mechanisms for this
During Pregnancy; what are the normal BP changes one can expect
During Pregnancy
- BP naturally lowers in the 1st and 2nd trimester
- this is a result of increased progesterone which dilates the vessels, leading to a decrease in SVR
in 3rd Trimester: BP rises back to the pre-pregnancy levels
week 28: the lowest BP mom will have during pregnancy: then it will climb
progesterone = dilate: decrease SVR: drop pressure
- but also; increased pooling in the legs (edema) and swelling, light headed, etc. becuase they have lost that resistance force
Chronic HTN v Gestational HTN
how do you know which it is
how do these differ from pre-eclampsia
Chronic HTN
- HTN they had prior to becoming pregnant
- defined as HTN prior to 20 weeks gestation
- they should have lower BP during this time up to the 3rd trimester; so if high now, it was likely high before
- can also be diagnosed afte 12 weeks PP (since the preg. related HTN should be gone)
Gestational HTN
- HTN they had as a result of pregnancy (or we just didn’t know if they had it before)
- define as HTN after 20 weeks gestation
- no other abnormalities present, jsut straight up HTN (no end organ damage signs, etc.)
Preeclampsia
- HTN in pregnancy with the addition of other features: maininly proteinuria
Chronic HTN in pregnancy
what is it
what do you do
labs, fetal testing etc.
CHTN
- HTN before pregnancy: before 20 weeks or afte 12 weeks PP
- can be stage 1 or stage 2 HTN (in normal HTn numbers: 130-139/80-89 (Stage1))
Manage Meds
- if on meds: off ACE/ARB
- HCTZ: ok
- prefer labataolol, nicardipine
Testing
Labs
- want to get baselines: to see if it develops into pre-eclampsia, HELLP syndrome, etc.
- CMP/EKG/24hr. urine (or spot check protein:Cr ratio)/eye exam
Fetal Testing
- 3rd trimester: NST (1-2x weekly depending on severity) assesing placenta compromise too
- growth US (Q4wk.; serial US starting at 28wk.)
- delivery ideally between 38-39 weeks
Gestaional HTn
what is it
diagnosis criteria
management
Gestational HTN
- HTN After 20 weeks gestation
- or HTN which resolves after 12 weeks PP
Diagnosis
- requires two BP readings 4 hours apart
- NO proteinuria: proteinuria = preeclampsia
- 2+ readings elevated BP 4 hours apart
Management
- weekly NST for fetal monitoing
- serial growth US
- serial weekly labs: LFTs, CBC, urine protien:Cr ratio (r 24 hour) {monitoring for development into preeclampsia}
- anti-hypertensive management: carvadilol, labatolol
delivery: between 37 -38 weeks weighing risk benefits for mom/baby
Pre-Eclampsia
Etiology
Pathology
Preeclampsia
- a pregnancy specific syndrome: can effect virtually every organ system
Etiology
- poorly known
- thought to have something to do with placental inflammatory reaction to paternal chromosomal influence triggering an immune type reaction
- results in: capillary leakage & 3rd spacing
Pathology (what basically happens as a result)
cardiac: HTN, increasd preload, endothelial damange, vasoconstrction
hematologic: hemoconcentation, thrombocytopenia, DIC, hemolysis
Fluid changes: edema
Renal: decreased perfusion, decreased GFR, proteinuira, AKI, ARF
Liver: infarction, hepatic hemotoma, rupture, impaire liver function
brain: cerebral edema, CVA (increased CSF pressures)
Pre-Eclampsia
Diagnosis
Mild V Severe
Diagnosis
- evidence of HTN via BP readings (2+ in 4 hours)
- evidence of Proteinuria
- additional symptoms: visual disturbances, fluid in lungs, SOB, abd pain
Mild
- HTN: 140/90
- proteinuria
Severe
- 160/110
- proteinuria
- lab abnormalities including
- LFTs elevated (“2x baseline”)
- platlets low ( < 100k)
Pre-Eclampsia
treatment
what can you give to those at increasd risk in 1st trimester
Preeclampsia Treatment
- delivery is the only cure: we like to wait/get baby to at least 34weeks if severe, mild can try 37 weeks
- monitor LFTs, CBC, & labs
- monitor fetus via : growth US & NST
- magnesium sulfate to prevent seizures
- corticosteroids to help fetal lung development upon delivery
- manage inpt. v outpt. deoending on severity
Prevention
- daily asprin starting at 12 weeks in first trimester for those high risk
- High Risk: DM, HTN, family hx., older age, smoker, etc.
HELLP Syndrome in Pregnancy
what is it
when does it occur
HELLP Syndrome
H = hemolysis (evidence via LDH and haptoglobin. bilirubin,etc.)
E = elevated
L = Liver enzymes (AST/ALT)
L= low
P = Platelets
can be a more severe form of preeclampsia (so HTN + Proteinuria) + these symptoms
or
can be on its own, absenc of proteinuria and HTN (seems more rare)
Eclampsia
what is it
when does it happen
treatment
Eclampsia
- a generalize tonic-clonic seizure with convulsions which has not underlying, attributable cause
- pre-eclampsia symptoms (HTN, proteinuria) + seizure
When
- can happen up to 6 weeks PP
- highest risk is withint first week of delivery
Complications from eclampsia
- abruption of placenta
- neurological defictis
- aspiration PNA
- pulmonary edema
- acute renal failure
- cardiac arrest
- death
Managemnet
- first line is magensium sulfate
- then if seizure continuing: move to the benzos or phenytonin
- anti-hypertensives to drop pressure (labatalol, nicardipine)
- diuretics
- delivery of baby
Anemia In Preganancy
why does it occur & causes of the anemia
symptoms/signs
what supplementation is recommended
Anemia in Pregnancy
- there is a natural hemodilution in pregnancy; increase in plasma volume but not as much of an increase in RBC production via erythropoetin
- baby is taking all your iron and calcium
- post-partum: there is a decent hemoconcentration back (as fluid is lost)
Causes
- IDA: iron deficiency aneami
- anemia from acute blood loss: vaginala dn c-section losses
Supplementation Recommendations
- for all women
- iron (can be within the prenatal vitamin)
- iron is constipating: give stool softener
Symptoms & Signs of anemia
- lethargy
- SOB
- palpations, chest pain
- dizzy
- HA and fainting
- pallor
- tachycardic
- soft ejection systolic murmur
Anemia in Pregnancy: IDA
labs & treatment
Iron Deficiency Anemia (IDA)
- a result of lack of iron, because baby is taking it all from you & during pregnancy you need more!!!!!
Labs
- hypochromic (not holding as much HGB)
- microcytic (small because pumping them out asap to try to carry as much o2 as it can)
- Hgb < 11 in first trimester, or < 11.5 in second trimester : check hgb at 1st trimester & at 28weeks
- additional labs: iron/iron binding capacity, reticulocytosis
Treatment
- Iron supplementation (IV or oral)
Anemia in Pregnancy: Acute Blood Loss
when might you seen this
labs to obtain
treatment
Acute Blood Loss
First Trimester: ectopic, aborption, hydatiform mole
more commonly: due to obstertirc hemorrage
PPH : loss of >1000 mL in any delivery modality
Labs to obtain
- after delivery or in 1st tri: CBC
- 1day post devleiry: get CBC to see how they’re compensating
Treatment
- blood transfucion: no clear guide on when bu if symptomatic: transfuse (around 7 start thinkin)
- iron supplementation
Additional causaes for Anemia in Pregnancy
decide the cause of the anemia via a HgbElectrophoresis
Sickle cell
anemai of chronic disease (rare)
folate/B12
Thalassemia
CKD
Hypothyroidism
UTI in pregnancy
why are they common : patho
labs to obtain
bugs
UTI = most common infection in pregnancy
Patho
- progesterone relaxes the mucosal sphincters: leading to the ability for bacterial to easily backflow from utertra up to bladder and even to utereters and kidneys (pyleo)
Pregnant Changes
- increased kidney size, dilation of calyces and ureters
- increased GFR
- vesiculoureteral reflux
Labs to Obtain
- urinaylsis
- urine culutre
Bugs
- 90% of the time its e coli
- could be klebsiella
- GBS too
