Medical Marijuana

Question 1

Epidolex

Answer 1

CBD product approved to treat childhood epilepsy including Lennox-Gastaut and Dravet

Question 2

D8 and THC-O

Answer 2

Synthetic THC made from CBD
Legal Loophole

Question 3

Can the use of marijuana in chronic pain reduce the need for opioids

Answer 3

Yes

Question 4

Endogenous compound that acts on cannabinoid receptors

Answer 4

endocannabinoids, particularly anandamide

Question 5

MOA of endocannabinoids

Answer 5

modulate the release of neurotransmitters from the presynaptic neuron

Question 6

CB1 receptors

Answer 6

Found in the CNS and mediate central, basically what makes you feel high + munchies. May also have some antiemetic effects

Question 7

CB2 receptors

Answer 7

Found in the periphery and mediate immune effects like inflammation and pain relief.

Question 8

CV effects

Answer 8

Possible tachycardia, postural hypotension, and red eyes

Question 9

Decreased intraocular pressure

Answer 9

only occurs at really high doses

Question 10

FDA opinion

Answer 10

Still does not approve and does not acknowledge that there may be any benefit in its use

Question 11

Smoking v Oral

Answer 11

Smoking = rapid absorbing, but will cause damage to respiratory tract

Oral = slower absorbing with some of the drug getting metabolized in the liver before entering the bloodstream.