Medical Imaging And Cartilage Flashcards

1
Q

Describe the fundamental principle of how X-Rays work

A

Within an X-ray tube electrons are accelerated towards a metal target (tungsten). Some of the X-rays, then hit a detector behind the patient. Some are attenuated by the patient (absorbed p, scattered p, or lose energy as they pass through). Amount of attenuation is dependent on the density number of tissue/material, and energy of X-ray beam. The detected X-rays are digitised and processed creating an image which is uploaded to the picture archiving and communication systems.

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2
Q

Describe the fundamental principles of how ultrasound scanning works

A

Ultrasound utilises sound waves. Crystal in the transducer probe oscillates creating high frequency sound waves. These travel through tissues and are reflected back from boundaries between tissues of different density. The probe detects reflected sound waves (echos) and converts them into electrical signal.
The time taken for echo to return is used to calculate where it was reflected from. The proportion of reflected waves is used to calculate the acoustic impedance mismatch in that place and intensity is displayed as greyscale.
Hyperechoic means more reflection and more white on image. Hypoechoic means less reflection and more dark on image. Acoustic shadowing means large acoustic impedance mismatch = sound waves are completely reflected back, none pass through, dark area behind bone, air, stones.

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3
Q

Describe the fundamental principles of how MRI works

A

An MRI scanner creates a strong magnetic field that aligns hydrogen atoms within the patient. A radio-frequency pulse is applied which ‘tips’ the aligned hydrogen atoms which creates a detectable magnetic field. This field induces an electoral a current in nearby coils in the MRI machine.
Varying signal intensities are produced by different tissues, these are then processed to create images. After the pulse ends, the hydrogen atoms relax back into alignment with the magnetic field of the MRI machine.

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4
Q

Describe the fundamental principles of how CT scanning works

A

X rays produced. There is an X ray tube on one side of a rotating gantry and detectors on the opposite site. The patient table moves through the gantry, process is similar to X rays. Cross-sectional slices of the patient is imaged. Detected signals is processed by computer to produce cross-sectional images

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5
Q

Describe the fundamental principles of how PET scan works

A

Administration of radiopharmaceutical:
- Pharmaceutical part - takes the compound to tissues of interest.
- Radionuclide part - sends signal from tissue of interest.
Nuclear decay of radionuclide occurs within tissues of interest emitting gamma radiation which is detected. Y a gamma camera close to patient. Gamma camera contains a scintillator (which converts signal into light). Light signal is amplified and processed by computers to produce images.
It gives functional and anatomical information

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6
Q

Describe the fundamental principles of how Fluoroscopy works

A

Process is similar to X-ray except pulsed or continuous X-rays are used creating moving images.
This can be used to examine anatomy, pathology, motion and function.
Images are often enhanced using contrast (barium/iodine), as they have a high atomic number which is a good absorber of X rays so it appears dense on image.

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7
Q

Explain the advantages and disadvantages of X rays

A

Advantages:
- Quick
- Portable
- Cheap
- Simple
Disadvantages:
- Radiation (but relatively low)
- One plane, two dimensional
- Cannot see all pathology
- Poor, soft tissue imaging

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8
Q

Explain the advantages and disadvantages of Ultrasound scanning

A

Advantages:
- Lack of radiation
- low cost
- Portable
- Dynamic (can see movement, assess blood flow).
Disadvantages:
- Operator dependent
- No bone or gas penetration
- Difficult with obese/frail/unwel patients
- Theoretical risk of overheating if misused

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9
Q

Describe the advantages and disadvantages of MRI

A

Advantages
- No radiation
- Good contrast
Disadvantages:
- Expensive
- Time consuming
- Fewer machines, fewer radiographers
- Contraindications (pacemakers, cochlear implants, metal, claustrophobia, lack of mental capacity)
- Contrast reactions
- Image quality relies on magnetic field strength.
- Contrast reactions

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10
Q

Explain the advantages and disadvantages of CT scanning

A

Advantages:
- Quick
- Good spatial resolution
- Can scan most parts of the body well (but not all)
Disadvantages:
- Radiation
- Does. It delineate sof tissue well
- Affected by artefact (movement, metal
- Requires breath holding (not all patients can)
- Overuse (fishing for diagnosis)
- Incidental findings
- Contrast reactions

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11
Q

Explain the advantages and disadvantages of PET scanning

A

Advantages:
- Good contrast and spatial resolution
- Can analyse anatomy and function
Disadvantages
- Physiological uptake of radiopharmaceutical
- Radiation does to patient
- Risk of radiation to others
- Radioactive waste produced
- Expensive and time consuming
- Radionuclide shortages

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12
Q

Explain the advantages and disadvantages of Floroscopy

A

Advantages:
- Dynamic studies, real time can assess function, carry out intervention
- Quick
Disadvantages
- Higher radiation dose than single X ray
- Radiation exposure to interventional clinician
- one plane, two dimensional
- Cannot see all pathology
- Poor soft tissue imaging

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13
Q

Give a clinical example of where X rays can be used

A

Chest X ray
Indications: Dyspnoea, cough, haemoptysis, chest pain, follow up post pneumonia
Diagnosis: Infection, pulmonary oedema, pleural effusion, pneumothorax, cancer.
Abdomen/Pelvis X ray
Indications: Neonatal, passing of urinary tract calculate, checking for presence of foreign bodies
Diagnosis: Obstruction, volvulus, perforation, colitis, calculate, abdominal aortic aneurysms
MSK
Indications: Trauma, pain, deformity, swelling, post relocation of joint, post reduction
Diagnosis: Fracture, dislocation, effusion, soft tissue injury, tumour, infection

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14
Q

Give a clinical example of how ultrasound scanning can be used

A

Solid organs - Appearance of tissue/organ, masses, bleeds, etc
Hollow structures - function, stones, flow, obstructions etc
Breast- Assessing lumps abnormally seen on screening mammogram
- Obstetrics - Pregnancy dating, foetal anomaly, placental location, foetal growth
- Musculoskeletal - Assessing muscles, tendons, ligament, joints, nerve, soft tissue masses.
Interventional - US guided injection/biopsies/drains/aspirations.

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15
Q

Give a clinical example of how MRI can be used

A
  • Central nervous system ( brain and spinal cord)
  • Head and Neck imaging
  • MSK imaging, bones/joints/soft tissues
  • GI e.g., MRCP, MRI liver
  • Cardiac MRI, MR angiography
  • Gynaecological imaging, prostate imaging
  • In paediatric/pregnancy to avoid radiation
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16
Q

Give clinical examples of how CT scans can be used

A

Diagnosis/guiding further investigation/management e.g.,
Trauma, bleeding, clot, ischaemia, infarcts, pain, cancer
Monitor conditions e.g.,
Cancer, ILD
Interventional:
Radiotherapy, CT guided biopsies/drains

17
Q

Give clinical examples of PET scanning can be used

A

Oncology - detection, staging, response to treatment
Neurological - Early diagnosis of Alzheimer’s disease. Location of seizure focus
Cardiac - Identification of poorly perfumed myocardium
Infection/Inflammation - Pyrexia of unknown orbit. Vascularised

18
Q

Give clinical examples of where Fluoroscopy can be used most efficiently

A
  • Diagnostic and Interventional
  • Vascular (Angiography) - e.g., cerebral, coronary, peripheral vascular ire, embolisation, angioplasty, stenting
  • GI e.g., urogram, hysterosalpingogram, nephrostomy, insertion
  • MSK (arthrogram, therapeutic joint injections, orthopaedic surgery).
19
Q

Describe the composition of cartilage in terms of its cells and extra cellular components

A
  • All have matrix containing proteoglycan and hyaluronic acid
  • All have chondrocytes
  • Some have elastic fibres
20
Q

Classify the 3 major types of cartilage and describe the structural differences between them

A

Hyaline cartilage: Matrix containing type 2 collagen. The hyaluronate proteoglycan aggregates are bound to the fine collagen matrix fibres. Dense tissue often contains fluid (water)
Elastic cartilage: Matrix contains many elastic fibres and Type 2 collagen in elastic lamellae (layers) - tough but flexible tissue.
Fibrocartilage (fibrous): Matrix contains a lot of type 1 (mainly) and some type 2 collagen fibres

21
Q

Relate the different distribution of hyaline cartilage to their function

A

Cell type: Chondrocyte (no other cell types are present)
- Chondrocytes are present alone, or if recently divided in small clusters called isogenous groups
- Chondrocytes within isogenous groups separate as they lay down extracellular matrix
- Avascular (without a blood vessel), with extensive extracellular matrix which allows for the diffusion of materials
- Extracellular matrix is solid and firm, but also rather pliable and therefore resilient to the repeated application of pressure.
- Hyaluronic acid assists resilience to the repeated application of pressure

22
Q

Relate the anatomical distribution of las tic cartilage and how it relates to their function

A

Cell type - Chondrocyte with no other cell type present
Also contains Elastic fibres which confers elastic tissue and it returns to their original position.
Dark staining material is an abundance of elastic fibres the lie in the extracellular matrix

23
Q

Relate the anatomical distribution of fibrocartilage and how it relates to their function

A

Cell types - Chondrocytes and fibroblasts
Fibroblast is a combination of dense regular connective tissue and hyaline cartilage. Cells are often seen to be distributed in row.there is no surrounding perichondium
Contains mainly type 1 collagen and some type 2 collagen fibres

24
Q

What is the anatomical locations of hyaline cartilage

A

Cartilages in nose
Tracheal wall
Respiratory tube cartilages in neck and thorax

25
Q

What is the anatomical location of elastic cartilage

A

The pinnacle of the ear (and the external part of the acoustic meatus)
The Eustachian tube (Ear drum to mouth)
The epiglottis

26
Q

What is the anatomical location of fibrocartilage

A

Intervertebral discs
Articulate discs of the sternoclavicular and temporomandibular joints
Menisci of the knee joint
Pubic symphysis

27
Q

What is the anatomical location and function of hyaline articulated cartilage

A

Found in articulate cartilage of a joint
Important point of attack in rheumatoid arthritis
In the adult, cells do not proliferate enough to repair damage. Instead, fibroblasts lay down scar instead. This calcifies with age and causes loss of flexibility

28
Q

What is Achondroplasia

A

Inherited mutation in the FGF3 receptor gene. This normally promotes collagen formation from cartilage. The endochondral ossification is affected, whilst the intro-membranous ossification is unaffected.
This results in a short stature but normal sized head and torso as long bones cannot lengthen correctly.

29
Q

What is the difference between Rheumatoid arthritis and Osteoarthritis

A

Osteoarthritis is an age related degeneration. There is mechanical failure of the articulate cartilage and narrowing of the joint space as bone rubs against bone
Rheumatoid arthritis is an autoimmune disease which causes the inflammation of a synovial membrane. This cause the thickening of the joint capsule. There is subsequent damage to the underlying bone and articulate cartilage. Both bone an d cartilage disintegrate.

30
Q

How does arthritis cause joint pain and how can you see it on an X-ray

A

In a normal knee joint, there is Hyaline cartilage and fibrocartilage menisci and permits smooth articulation. In an osteoarthritis knee joint, there is degeneration of the both types of cartilage. There is narrowing of the joint space and growth of bony spurs which cause inflammation a and pain
On an C-ray a normal knee joint will have the hyaline cartilage and fibrocartilage menisci which keeps the femur and tibia well separated. However in an osteoarthritic knee joint, there is degeneration of the cartilage which will cause narrowing of the joint between femur and tibia.