Medical Imaging Flashcards

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1
Q

How are x-rays produced in a modern x-ray tube?

A

Electrons are emitted from a filament, heated by an electric current and enter a vacuum with an anode (a metal e.g. tungsten) and a cathode (filament) with a high potential difference. When the electrons hit the anode, x-rays are produced.

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2
Q

What are the two ways that x-rays can be produced?

A
  • When fast moving electrons smash into a metal target. As the electron interacts with the electric field around the nucleus, an x-ray photon is produced.
  • When a fast moving electron ejects an inner electron in an atom of the target metal. An electron from a higher energy level moves to occupy the vacancy and an x-ray photon is produced.
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3
Q

What is the maximum energy of a photon given by through a potential difference?

A

E (max) = eV

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4
Q

What is Compton scattering?

A

The effect whereby an x-ray deflected by interaction with an orbital electron has a longer wavelength than its initial wavelength. The electron is emitted at high speed.

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5
Q

What is attenuation?

A

The gradual decrease in intensity?

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6
Q

What are the four ways x-rays can interact with matter?

A
  • Simple scattering
  • Photo electric effect
  • Compton scattering
  • Pair production
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7
Q

Explain simple scattering.

A

When low energy x-rays encounter the electrons in an atom, the energy of the x-ray photon is not sufficient to cause ionisation so the photon is scattered (deflected so its direction changes), but there is no change in energy or absorption of the photon.

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8
Q

Explain the photoelectric effect (x-rays).

A

x-rays can cause the emission of photo-electrons if the energy of the photon equates or exceeds the work function of the metal surface, meaning the photon is absorbed and the resultant photo-electron has a kinetic energy equal to the photon energy minus the work function.

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9
Q

Explain the Compton scattering (x-rays).

A

When the x-ray comes in contact with an electron, a scattered x-ray photon is produced as well as a photo electron. Due to conservation of momentum the photon deflected can have a longer wavelength due to it being ejected at a large angle meaning it will have lost energy. For mass and energy to be conserved the electron must have a low kinetic energy.

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10
Q

Explain pair production (x-rays).

A

In a beam of high frequency electrons, an x-ray photon can interact with the nucleus of an atom producing an electron and positron pair.

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11
Q

What is intensity?

A

Power per unit area.

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12
Q

What is Computerised Axial Tomography (CAT)?

A

A process using multiple x-ray scans to produce images of “slices” through the body in one plane, to produce a 3D image.

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13
Q

What is the problem with 2D x-rays?

A

Traditional x-rays show a shadow image if the part of the body through which the x-rays have passed. Inevitably there will be overlap of images of different organs or bones above or below each other.

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14
Q

How is a CAT scan image produced?

A

A thin fan-shaped x-ray beam is produced and rotated around the patient and by the time it has completed one complete revolution, bot it and the detectors have moved up one centimetre, this continues and gets fed into a computer, which processes the information to create an image.

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15
Q

What are the advantages of a CAT scan over an x-ray image?

A

It provides the doctor with a very accurate image of the positions of internal organs without being obscured by other structures in the body. They are particularly sensitive to changes in density and give much better contrast for different soft tissues. The images can be looked at from many angles and the computer technology allows the doctor to remove areas with the density of bone or air by making them transparent.

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16
Q

What is a tracer?

A

A radioactive substance, either ingested by or injected into a patient. It emits gamma photons to be detected by a gamma camera.

17
Q

What does a gamma camera do?

A

It detects gamma photons emitted from a patient given a radioactive tracer. It is used to produce a real-time image of the path of the tracer through the body.

18
Q

What is a collimator?

A

A device for producing a parallel sided beam of electromagnetic radiation.

19
Q

What is a scintillator?

A

A material that produces many photons of visible light when struck by a high-energy photon.

20
Q

What is a photomultiplier tube?

A

A device used to give a pulse of electrons for each incident photon.

21
Q

Why must gamma sources be used as tracers?

A

Because alpha and beta particles would be absorbed by the body rather than pass through the detector and would damage the body due to their ionising properties.

22
Q

What are the requirements for the radioactive tracer?

A
  • Must have a long enough half life for the procedure but short enough to not cause damage to the patient’s cells (a few hours is ideal).
  • It must be non-toxic to humans
  • It must be possible to get the tracer to the necessary position e.g. via injection
23
Q

How does a gamma camera work?

A

The gamma camera detects photons emitted by the source in the patient’s body, a block of lead with vertical holes is next to the patient to only let through photons in the axis of the collimator to the detector. The gamma photons then strike a scintillator (e.g. sodium iodide) to hit an array of photo-multiplier tubes in a hexagonal pattern. Each tube initially emits one electron per photon (photoelectric effect) but it later amplifies giving electrical pulses that feed into a computer.

24
Q

Why is sodium iodide used as a scintillator?

A

Because it is a fluorescent material that scintillates when it absorbs a gamma photon.

25
Q

What is Positron Emission Tomography (PET)?

A

The use of gamma photons produced when positrons annihilate with electrons inside the body to map out biologically active areas within the body.

26
Q

How is a PET scan conducted? (long answer)

A

A tracer is introduced to the bloodstream combined with a biologically active molecule (e.g. fluorodeoxyglucose) tagged with fluorine-18, a beta plus emitter. After an hour, the FDG becomes concentrated in certain parts of the body due to some cells consuming more glucose than others (e.g. cancerous cells). In the scan concentrated areas will be brighter. The ring of detectors in the PET scanner detect the gamma radiation from the tracer. Each positron emitted annihilates with electron in the patient’s atoms, causing two gamma rays to be produced in opposite directions. These will then be detected by the gamma camera.

27
Q

What are PET scans used for?

A
  • To study blood flow and metabolism
  • To detect problems with the nervous system e.g. Parkinson’s, schizophrenia and strokes.
  • To find changes in the brain that may lead to epilepsy
  • To study and analyse cancers
  • To determine how advanced a cancer is so it can be treated
28
Q

What is ultrasound?

A

Longitudinal waves above the upper limit of human hearing, with frequencies above 20,000 Hz.

29
Q

What is a transducer?

A

A device such as a microphone which coverts a non-electrical signal like sound into an electrical one.

30
Q

What is the Piezoelectric effect?

A

The change in volume of a material when a potential difference is applied across its opposite faces. Alternatively it is the production of an induced e.m.f when certain crystals are placed under stress.

31
Q

What are the benefits of ultrasound scanning?

A
  • There are no known dangers associated with it as it is not a type of ionising radiation but the intensity should still be kept low to prevent it being destructive
  • It can be used to obtain real-time images of soft tissue
  • The machines are inexpensive and portable.
32
Q

What makes ultrasound different to other types of scanning

A
  • Ultrasound is reflected from surfaces rather than going right through the body
  • Echos are used
  • Ultrasound must be pulsed and there is a delay between the ultrasound being emitted and detected
33
Q

What is acoustic impedance?

A

Defined by the equation Z = ρc where ρ is the density and c is the speed of sound in the material.

34
Q

What is impedance matching?

A

The reduction of intensity of reflected ultrasound at the boundary between two substances achieved when the two substances have similar or identical acoustic impedances.

35
Q

What happens in an A-scan?

A

A short pulse of ultrasound waves is sent into the body, at the same time an electron beam travels across the screen of a cathode ray oscilloscope . the transducer receives reflected pulses which cause vertical spikes on the CRO screen .

36
Q

What happens in a B-scan?

A

A real time 2D or 3D image of the area being scanned is built up from many returning echos recorded from several transducers in an array or a transducer is moved to different positions or angles around the patient. The greater the amplitude of the reflected pulse, the brighter each dot will be.

37
Q

How is the Doppler effect used in the measurement of blood flow?

A

In order to measure the speed of blood-flow the frequency of reflected ultrasound pulses must be obtained. Blood flow can be colour coded to show the direction of blood flow to see if a vessel is an artery or a vein.