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Pharma Asma > Mediators > Flashcards

Mediators Flashcards

1
Q

Mediators

Amino acid derivatives?

A

Histamine & Serotonin

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2
Q

Mediators

Endogenous peptides?

A

Kinins

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3
Q

Mediators

Fatty acid derivatives?

A

Eicosanoids (prostaglandins, leukotrienes, lipoxins)

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4
Q

Mediators

Gas?

A

NO (Nitric oxide)

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5
Q

Stored in mast cells, basophils, lung, intestinal mucosa?

A

HISTAMINE

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6
Q

Smooth muscle,Endothelial cells, Brain

Which receptor?

A

H1

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7
Q

Major Biologic Effects:

Acute allergic responses

A

H1 which locate in: Smooth muscle,Endothelial cells, Brain

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8
Q

Gastric parietal cells,Cardiac muscle, Mast cells, Brain have which receptor?

A

H2

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9
Q

Major Biologic Effects:

Secretion of gastric acid

A

H2: Gastric parietal cells,Cardiac muscle, Mast cells, Brain

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10
Q

Histamine H1 receptor blockers

First generation?

A

Diphenhydramine, Promethazine.

Has a sedating effect

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11
Q

Histamine H1 receptor blockers

Second generation?

A

Loratidine

Non-sedating effect

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12
Q

Blockers of H2 receptors inhibit gastric acid secretion

A

Ranitidine

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13
Q

Ranitidine Used for treatment of:

A

¢ Gastritis

¢ Peptic ulcers

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14
Q

Used in treatment of : ¢ Vertigo of Ménière’s disease & other balance
disturbances of vestibular origin

A

H3- receptor blockers e.g. Betahistine

Side effects: ¢ May produce headache & insomnia.

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15
Q

Cause vasodilatation of vascular smooth muscle?

A

PROSTAGLANDINS

Remember histamine for contracts smooth muscle!!

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16
Q

Acts on parietal cells of stomach to protect gastric mucosa?

A

PROSTAGLANDINS

17
Q

Induce labor?

A

PROSTAGLANDINS

18
Q

Decrease intraocular pressure?

A

PROSTAGLANDINS

19
Q

Contracts large vessels by a direct action & relaxes other vessels by releasing NO , Increases capillary pressure &permeability.

A

ACTIONS OF SEROTONIN

20
Q

Drug use for CARCINOID SYNDROME?

A 
Serotonin antagonists (cyproheptadine, 5HT 2 antagonist)
could be administered to control diarrhea, flushing &malabsorption.

Pharma Asma (1 decks)

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