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Pathologie > Médiateurs chimiques > Flashcards

Médiateurs chimiques Flashcards

1
Q

Histamine: Source

A

Mastocytes, basophiles (gran.), plaquettes

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2
Q

Histamine: Rôle

A

Vasodilatation, perméabilité vasculaire

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3
Q

Complément: Source

A

Hépatocytes (plasma)

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4
Q

Complément: Rôle

A

Activation/recrutement leucocytaire (chimiotaxisme), vasodilatation (via stimulation des mastocytes), activation du MAC

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5
Q

Kinines: Source

A

Hépatocytes (plasma)

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6
Q

Kinines: Rôle

A

Perméabilité vasculaire, douleur, vasodilatation, contraction des muscles lisse

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7
Q

Prostaglandines: Source

A

(Via voie des kinines) Mastocytes, leucocytes

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8
Q

Prostaglandines: Rôle

A

Douleur, vasodilatation, fièvre

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9
Q

Leucotriènes: Source

A

(Via voie des kinines) Mastocytes, leucocytes

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10
Q

Leucotriènes: Rôle

A

Chimiotaxisme, perméabilité vasculaire

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11
Q

PAF: Source

A

Mastocytes, leucocytes

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12
Q

PAF: Rôle

A

Chimiotaxisme, aggrégation plaquettaire***

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13
Q

Cytokines (TNF, IL-1): Source

A

Macrophages, cellules endothéliales, mastocytes

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14
Q

Cytokines (TNF, IL-1): Rôle

A

Locale: Activation endothéliale

Systémique: fièvre, hypotension/choc

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15
Q

Chimiokines: Source

A

Leucocytes, macrophages activés

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16
Q

Chimiokines: Rôle

A

Chimiotaxisme

17
Q

NO: Source

A

Cellules endothéliales, macrophages

18
Q

NO: Rôle

A

Diminution de la réaction inflammatoire, bactéricide

19
Q

Enzymes lysosomiales: Source

A

Macrophages et neutrophiles

20
Q

Enzymes lysosomiales: Rôle

A

Destruction (micro-organismes/tissus endommagés)

21
Q

Radicaux libres (ROS): Source

A

Macrophages et neutrophiles

22
Q

Radicaux libres (ROS): Rôle

A

Destruction (micro-organismes/tissus endommagés)

23
Q

Neuropeptides: Source

A

Nerfs sensitifs, leucocytes

24
Q

Neuropeptides: Rôle

A

Douleur, perméabilité vasculaire, tonus vasculaire

25
Q

BONUS: Responsables de la vasodilatation

A

Histamine, prostaglandines

26
Q

BONUS: Responsables de la perméabilité vasculaire

A

Histamine, complément, leucotriènes

27
Q

BONUS: Responsables du chimiotaxisme

A

Chimiokines (IL-1, TNF), complément, leucotriènes

28
Q

BONUS: Responsables de la fièvre

A

Prostaglandine, chimiokines (IL-1, TNF)

29
Q

BONUS: Responsables de la douleur

A

Prostaglandine, neuropeptides, bradykinine (!)

30
Q

BONUS: Responsables du dommage tissulaire

A

ROS, enzymes lysosomiales

Pathologie (1 decks)

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