Médiateur - source - action Flashcards

1
Q

Histamine

A

Plaquettes
Mastocytes
Basophiles

Augmentation de la perméabilité vasculaire
Vasodilatation

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2
Q

Complément

A

Hépatocytes (plasma)

Activation et chimiotaxie des leucocytes
MAC
Vasodilatation par stimulation des mastocytes

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3
Q

Kinines

A

Hépatocytes (plasma)

Perméabilité vasculaire
Contraction musculaire lisse
Vasodilatation
Douleur

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4
Q

Prostaglandines

A

Mastocytes
Leucocytes

Vasodilatation
Fièvre
Douleur

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5
Q

Leucotriènes

A

Mastocytes
Leucocytes

Perméabilité vasculaire
Chimiotaxie

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6
Q

PAF (facteur d’activation plaquettaire)

A

Leucocytes
Mastocytes

Chimiotaxie

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7
Q

Cytokines (+ exemples)

A

TNF, IL-1

Macrophages
Cellules endothéliales
Mastocytes

Locale
- activation endothéliale

Systémique

  • fièvre
  • hypotension/choc
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8
Q

Chimiokines

A

Leucocytes
Macrophages activés

Chimiotaxie

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9
Q

NO

A

Macrophages
Cellules endothéliales

Diminuer réaction inflammatoire
Effet bactéricide

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10
Q

Enzymes lysosomiales

A

Macrophages
Neutrophiles

Destruction (micro-organismes/tissu endommagé)

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11
Q

ROS

A

Macrophages
Neutrophiles

Destruction (micro-organismes/tissu endommagé)

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12
Q

Neuropeptides

A

Nerfs sensitifs
Leucocytes

Douleur
Perméabilité vasculaire
Tonus vasculaire

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13
Q

Vasodilatation

A

Histamine

PG

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14
Q

Perméabilité vasculaire

A

Histamine
Complément
LT

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15
Q

Chimiotaxie

A

Chimiokines (TNF, IL-1)
Complément
LT

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16
Q

Fièvre

A

Chimiokines (TNF, IL-1)

PG

17
Q

Douleur

A

PG
Bradykinine
Neuropeptides

18
Q

Dommage tissulaire

A

Enzymes lysosomiales

ROS