medcon2 Flashcards
Skin function
Thermoregulation
Sensation
Metabolism of Vit D
Protects against shear
Protects from water loss
Epidermis
Regeneration (45-75 days)
Prevents water loss- 90% keratinocytes
Synthesizes vit D
Provides pigmentation
Protects against shear, friction, and toxic irritants (Langerhans cells)
Dermis
Organs and vasculature (ECM)
Thickest layer of skin 2-4mm
Provides structure (collagen) and elasticity (elastin) to skin through fibroblasts
Hypodermis
Superficial fascia
Contains deep blood vessels and nerve endings
Insulation, reserve energy, cushion (fatty layer/subcutaneous)
Effects of aging
Dermal thickness
Fatty layer
Collagen and elastin
Sensation and metabolism
Sweat glands
Circulation and perfusion
Epidermal regeneration
Wound healing phase 1
Hemostasis
Phase 1: hemostasis
immediate- platelets
vasoconstriction
occurs immediately after injury
How: platelet aggregation, fibrin deposition, clot is end product
Wound healing phase 2
Inflammatory
Phase 2: Inflammatory
0-4 days- neutrophils, macrophages
vasodilation and phagocytosis
starts at time of injury and lasts 3-7 days
How: increased perfusion, vessel permeability, temperature
Wound healing phase 3
Proliferation
Phase 3: Proliferation
4-21 days-macrophages, fibroblasts, endothelial cells, epithelial cells
Overlaps and follows the inflammatory occurs
How: angiogenesis- capillary buds extend into the wound bed
Granulation- Collagen synthesis by fibroblasts
Wound healing phase 4
Remodeling
Phase 4: remodeling
Up to 2 years- fibroblasts
Wound contraction and collagen reorganization
Begin as granulation tissue is formed. Predominantly occurs 21-28 days after injury, can continue for 1-2 years post injury until it reaches maturation
How: collagen synthesis and lysis
Chronic remodeling- imbalance in collagen synthesis and lysis, dehiscence, keloids
Acute wound
Healing sequence continuous and within expected time frame
Little to no complaints
Chronic wound
Failure/delay of healing
>6 months
Does not respond to regulatory growth signals
Associated with repeated trauma, poor perfusion/oxygenation, excessive inflammation, concomitant disorders/genetic factors
Dormant, senescent cells