MED QUIZ 2 Flashcards
Glucagon, Dextrose, Epinephrine (non-cardiac), Albuterol, Nitrous Oxide, Nitroglycerin
GLUCAGON - AKA
GlucaGen
GLUCAGON - class
- HYPERGLYCEMIC AGENT
- PANCREATIC HORMONE
- INSULIN ANTAGONIST
GLUCAGON - MOA
INCREASE BLOOD GLUCOSE LEVEL BY STIMULATING GLYCOGENOLYSIS
GLUCAGON - INDICATIONS
- HYPOGLYCEMIA
- BETA-BLOCKER/ CALCIUM CHANNEL BLOCKER TOXICITY (medicines that lower blood pressure) TOXICITY
GLUCAGON - CONTRINDICATIONS
- HYPERGLYCEMIA
- HYPERSENSITIVITY
GLUCAGON - ADVERSE REACTIONS/SIDE EFFECTS
- CNS: DIZZINESS, HEADACHE
- CV: HYPERTENSION, TACHYCARDIA
- GI/GU: N/V
OTHER: REBOUND HYPOGLYCEMIA
GLUCAGON - DRUG INTERACTIONS
INCOMPATABLE IN SOLUTION WITH MOST OTHER SUBSTANCES
GLUCAGON - DOSAGE ADMINISTRATION ADULT
HYPOGLYCEMIA: 1 mg IM
BETA BLOCKER/CALCIUM-CHANNEL BLOCK TOXICITY: 1-5 mg IV/IO (may repeat 1 in 15 min)
GLUCAGON - DOSAGE ADMINISTRATION PEDI
0.1 mg/kg (max: 1mg) IM
GLUCAGON- DURATION OF ACTION
ONSET: 1 minute
PEAK EFFECT: 5-20 minutes
DURATION: 60-90 minutes (1hr-1 1/2 hr)
GLUCAGON - CONSIDERATIONS
- FIRST LINE AGENT-ONLY IF CANT GET IV ACCESS
- INEFFECTIVE IF GLYCOGEN STORES DEPLETED
- HIGHER INCIDENCE OF REBOUND HYPOGLYCEMIA-USE WITH ORAL GLUCOSE/DEXTROSE IF CAN
DEXTROSE - CLASS
Carbohydrate
DEXTROSE -AKA
D5W, D10, D25
DEXTROSE - INDICATIONS
Hypoglycemia (<60 mg/dl) and unresponsive
DEXTROSE -MOA
Rapidly increases serum glucose levels
DEXTROSE -CONTRAINDICATIONS
Suspected ICP or intracranial hemorrhage
DEXTROSE -ADVERSE REACTIONS/SE
CNS: cerebral hemorrhage, cerebral ischemia
Respiratory: PE
Other: hyperglycemia, extravasation leads to tissue necrosis
DEXTROSE - DRUG INTERACTIONS
Sodium bicarb. may decrease effectiveness
DEXTROSE - DOSAGE ADMINISTRATION NATIONAL (ADULT+PEDI)
Adult: 12.5-25 gm slow IV/IO push. May repeat x1 in 5 min if BGL < 60 mg/dl
Pedi: 0.5 gm/kg slow IV push. May repeat in 1x in 5 min if BGL < 60 mg/dl
DEXTROSE - DOSAGE ADMINISRATION RI (ADULT+PEDI)
Adult: D10W 250 ml (25g) IV over 5 minutes, may repeat in 5 minutes if bG <60 mg/dl.
Pedi: D10W 5 ml/kg over 5 minutes, may repeat in 5 minutes if bG <60 mg/dl.
DEXTROSE - DURATION OF ACTION
Onset: < 1 min
Peak: variable
Duration: variable
DEXTROSE - SPECIAL CONSIDERATIONS
Administer thiamine prior to dextrose in known or suspected alcoholic or malnourished pts
Don’t administer to pt with known CVA unless hypoglycemia documented
EPINEPHRINE (NON-CARDIAC) - AKA
Adrenalin
EPINEPHRINE (NON-CARDIAC) - CLASS
Sympathomimetic
EPINEPHRINE (NON-CARDIAC) - MOA
Bronchodilation, vasoconstriction, increased heart rate/contraction strength
EPINEPHRINE (NON-CARDIAC) - INDICATIONS
- ALLERGIC REACTION
- SEVERE ASTHMA NOT RESPONDING TO OTHER THERAPIES
- CROUP
EPINEPHRINE (NON-CARDIAC) - CONTRAINDICATIONS
- Hypertension
- Hypothermia
- Pulmonary edema
- Myocardial ischemia
- Hypovolemic shock
EPINEPHRINE (NON-CARDIAC) - ADVERSE REACTIONS/SE
- CNS: nervousness, restlessness, headache, tremor
- CV: arrhythmias, chest pain, hypertension, tachycardia
- GI/GU: N/V
EPINEPHRINE (NON-CARDIAC) - DRUG INTERACTIONS
Potentiates other sympathomimetics
EPINEPHRINE (NON-CARDIAC) - DOSE + ADMINISTRAION ADULT NAT
- Anaphylaxis or extreme asthma: 0.3 mg of a 1:1,000 solution IM or one adult autoinjector. May repeat every 5 min if no effect to a max od 3 doses
- Epipen: 0.3mg of 1:2000 solution
EPINEPHRINE (NON-CARDIAC) -DOSE + ADMINISTRAION PEDI NAT
- Anaphylaxis or extreme asthma
Pt under 30kg (66lbs): 0.15mg of a 1:1000 solution IM or one pediatric autoinjector (May repeat every 5 min if no effect to a max of 3 doses) - Pt over 30kg: same as adult
- Suspected croup: 0.5mL of 2.25% epinephrine solution in 3mL Normal Saline (“Racemic Epinephrine”), via nebulizer
- Epipen: 0.15mg of 1:2000 solution
EPINEPHRINE (NON-CARDIAC) -DOSE + ADMINISTRAION ADULT RI
- Anaphylaxis or extreme asthma:
1:1000, 0.3 mg IM (lateral thigh) [auto-injector preferred] every 5 min, if no improvement, max of 3x doses. Additional doses require MEDICAL CONTROL authorization.
> pts > 50 y.o. or w/ history of cardiac disease, administer 0.15 mg. - Respiratory Distress (Asthma/COPD/RAD):
asthma in extremis, contact MEDICAL
CONTROL authorization to administer EPINEPHRINE (1:1,000) 0.3 mg IM (lateral thigh) [auto-injector preferred], repeat every 15 minutes x2.
EPINEPHRINE (NON-CARDIAC) -DOSE + ADMINISTRAION PEDI RI
- Anaphylaxis or extreme asthma: (1:1000) 0.15 for
patients 15-30 kg (33-66 lbs. or 0.3 mg for patients > 30 kg (66 lbs.) IM [lateral] thigh (auto-injector preferred) every 5 minutes if no improvement to max of 3 doses.
Additional doses require authorization from MEDICAL CONTROL. - Respiratory Distress (Asthma/RAD/Croup): significant respiratory distress or stridor at rest, EPINEPHRINE (2.25% solution) 0.5 ml/3 ml NS or EPINEPHRINE 5 mg (1mg/1ml concentration) via SVN, may repeat x1… if continued MED CONTROL (1:1000) 0.15-0.3 mg IM (lateral thigh) [auto-injector preferred]
EPINEPHRINE (NON-CARDIAC) - DURATION OF ACTION
Onset: immediate
Peak: immediate
Duration: several minutes
EPINEPHRINE (NON-CARDIAC) - SPECIAL CONSIDERATIONS
- Use of antihistamines, corticosteroids and epinephrine offer no benefit in ACE-I related angioedema.[lisinopril, ramipril, captopril, benzapril, quinapril, enalapril]
- MAKE 1:10,000 EPI FROM 1:1,000 EPI [1ML 1:1,000 : 9ML NORMAL SALINE = 1:10,000 EPI]
ALBUTEROL -AKA
1 Proventil
2. Ventolin
ALBUTEROL -CLASS
- Sympathomimetic
- Bronchodilator
ALBUTEROL - MOA
Selective beta 2 agonist, stimulates sympathomimetic NS-result is smooth muscle relaxation in bronchial tree and peripheral vasculature
ALBUTEROL- INDICATIONS
Bronchospasm (COPD, asthma, RAD etc.)
ALBUTEROL - CONTRAINDICATIONS
- Known hypersensitivity
- Tachycardia (high HR)!
- CHF!
… IF GIVE TO PT W/ HIGH HR AND/OR CHF WILL FLASH THEM AKA TANK BP
ALBUTEROL - ADVERSE REACTIONS/SE
Often dose related
CNS: headache, fatigue, lightheadedness, irritability, restlessness, aggressive behavior
Respiratory: PE, hoarseness, nasal congestion, increased sputum
CV: hypertension, tachycardia, arrhythmias, chest pain
GI/GU: N/V, dry mouth, epigastric pain
Musculoskeletal: tremors
ALBUTEROL - DRUG INTERACTIONS
Tricyclic antidepressants may potentiate vascular effects. Common ones include:
Amitriptyline (Elavil)
Amoxapine (Asendin)
Desipramine (Norpramin)
Doxepin (Sinequan)
Imipramine (Tofranil)
Nortriptyline (Pamelor)
Protriptyline (Vivactil)
Trimipramine (Surmontil)
ALBUTEROL -DOSAGE ADMINISTRATION ADULT NAT
Adult: 2.5 mg via inhalation over 10-15 min. May repeat 3 times. NEBULIZER 6-8LPM.
ALBUTEROL-DOSAGE ADMINISTRATION PEDI NAT
Pedi: 2.5 mg via inhalation over 10-15 min. May repeat 3 times. NEBULIZER 6-8LPM.
ALBUTEROL –DOSAGE ADMINISTRATION ADULT RI
- Respiratory distress(COPD…): 2.5-5 mg (initial dose should include IPRATROPIUM 500 mcg, subsequent doses may be +/- IPRATROPIUM) via SVN 6-8LPM (may repeat to a max of 4 doses).
- Allergic reaction: 2.5-5 mg (+/- IPRATROPIUM) via SVN for continued wheezing (may
repeat x3). - Crush injury: 5 mg via SVN for patients with suspected hyperkalemia
ALBUTEROL -DOSAGE ADMINISTRATION PEDI RI
- ≥ 2 yo with suspected reactive airway disease (RAD)/asthma: 2.5-5 mg (initial dose should include IPRATROPIUM 500 mcg, subsequent doses may be +/- IPRATROPIUM) via SVN 6-8LPM for continued wheezing,
(may repeat x3). - Allergic reaction: 2.5-5 mg (+/- IPRATROPIUM) via SVN for continued wheezing (may repeat x3).
ALBUTEROL -DURATION OF ACTION
Onset: 5-15 min
Peak: 30 min - 2 hrs
Duration: 3-4 hrs
ALBUTEROL -SPECIAL CONSIDERATIONS
- May worsen angina pectoris and arrhythmias
- Administer EMS albuterol rather than pts own
NITROGLYCERIN - AKA
- Nitrostat
- Nitro-bid
- Tridil
NITROGLYCERIN - CLASS
Vasodilator
NITROGLYCERIN - MOA
- smooth muscle relaxant - VASODILATION
- Reduces preload & afterload - result reduced workload on the heart & decreased myocardial O2 demand
NITROGLYCERIN - INDICATIONS
chest pain that has cardiac etiology (cause)
NITROGLYCERIN - CONTRAINDICATIONS
- Hypotension
- Hypovolemia
- Intracranial bleeding OR head injury
- Pericardial tamponade (JVD, faint H sounds)
- in past 24 hrs pt took male enhancement/blood thinner:
a. Cialis aka tadalafil (48hrs)
b. Levitra aka Vardenafil
c. Viagra aka Sildenafil
NITROGLYCERIN - ADVERSE REACTIONS/SE
- CNS: headache, dizziness, weakness
- CV: reflex, tachycardia, syncope, hypotension
- GI/GU: N/V, dry mouth
- MUSCULOSKELETAL: muscle twitching
- OTHER: diaphoresis
NITROGLYCERIN - DRUG INTERACTIONS
OTHER VASODILATORS/ ERECTILE DYSFUNCTION DRUGS — CAUSE EXTREME HYPOTENSION
NITROGLYCERIN - DOSAGE AND ADMINISTRATION ADULT NAT
0.4 mg SL (repeat every 5min if SBP > 100 with no max)
NITROGLYCERIN - DOSAGE AND ADMINISTRATION PEDI NAT
NOT RECOMMENDED
NITROGLYCERIN - DOSAGE AND ADMINISTRATION ADULT RI
- ACUTE DECOMPENSATED HEART FAILTURE/CHEST PAIN: 0.4 mg SL every 5 minutes if SBP > 100
0.4 mg tabs, 0.4 mg metered
dose spray, or lingual powder
NITROGLYCERIN - DOSAGE AND ADMINISTRATION PEDI RI
NOT RECOMMENDED
NITROGLYCERIN - DURATION OF ACTION
onset: 1-3 min
peak: 5-10 min
duration: 20-30min
NITROGLYCERIN - SPECIAL CONSIDERATIONS
- HYPOTENSION MORE COMMON IN ELDERLY
- NITRO DECOMPOSES IN LIGHT/HEAT MUST BE IN AIRTIGHT CONTAINER - ASK PTS ABOUT HOW THEY STORE PERSCRIBED NITRO
- MAY HAVE STINGING EFFECT UNDER TONGUE
NITROUS OXIDE - AKA
- Nitronox
- N2O
NITROUS OXIDE - CLASS
Inhaled anesthetic
NITROUS OXIDE -MOA
Causes general CNS depression by partially inhibiting action potential in neurons
NITROUS OXIDE - INDICATIONS
PAIN
NITROUS OXIDE - CONTRAINDICATIONS
- Known hypersensitivity
- AMS
- Alc/drug intoxication
- Pregnancy
- chest trauma
- respiratory distress
- traumatic brain injury
- ICP
- decompression sickness
NITROUS OXIDE - ADVERSE REACTIONS/SE
- CNS: dizziness, euphoria, confusion
Respiratory: respiratory depression - CV: hypotension
- GI/GU: N/V
NITROUS OXIDE - DRUG INTERACTIONS
Other CNS depressants potentiate CNS and respiratory effects
NITROUS OXIDE - DOSAGE ADMINISTRATION ADULT NAT
Adult: 50/50 nitrous oxide/oxygen blend via facemask
NITROUS OXIDE - DOSAGE ADMINISTRATION PEDI NAT
Pedi: 50/50 nitrous oxide/oxygen blend via facemask + not recommended in infants
NITROUS OXIDE - DOSAGE ADMINISTRATION ADULT RI
Pt comfort, moderate to severe pain (scale >6): inhaled NITRONOX (50/50 nitrous oxide and oxygen blend)
NITROUS OXIDE - DOSAGE ADMINISTRATION PEDI RI
Pt comfort, severe pain (scale >6), consider:
inhaled NITRONOX (50/50 nitrous oxide and oxygen blend)
NITROUS OXIDE - DURATION OF ACTION
onset: immediate
peak: 2-5 min
duration: 1 min after cessation of administration
NITROUS OXIDE - SPECIAL CONSIDERATIONS
- Pt must be able to self administer and hold mask themselves
- Keep in mind blend only delivers 50% O2