Med Onc Bits

Question 1

Name some applications of Durvalumab for lung Ca (and trials and benefit, who does it not benefit, alternative drug trial ongoing, typical dosing)

This card fucking sucks.

Answer 1

1) Adeno:
Pacific - Stg III and stable after standard treatment (e.g 55/20) and 2 cycles platinum.
1 yrs of q2week Durv = 66% 2yr OS vs 56%, also DMFS including decreased mets to the noodle.
No benefit in EGFR+
LAURA trial suggests Osimertinib may be even better with high PFS rates OS data soon (at 3 years)/

2)SCLC:
LS - Adriatic - 3yr OS 60%
ES - Caspian - Increase OS 3 months to 13months from 10months

Question 2

A NSCLC may (with debate) be considered for chemo at what stage?

When is chemo generally always indicated?

Most common regimen?
Give doses:

Answer 2

T2b = 4cm, NO = Stage IIA

Stg III = begins at T1-T4N1 or T4NO,

Common regimen:
1) Weekly Cisplatin (50mg/m2 D1) + Q4W Etoposide (50mg/m2 D1-5, and D29-33)
2) Weekly Carboplatin (2AUC) and weekly Paclitaxel (45mg/m2)