Med Ed Videos Flashcards
Transient tachypnea of newborn
self-limiting
seen after c-section in healthy babies
-DX: CXR –> hyperexpanded lungs, wet
pathophys, DX of IVH, and TX
vascular lining of ventricles bleed –> bleeding and increased ICP
cranial dopplers
TX - decrease ICP (VP shunts, drains)
NEC
dead gut –> bloody bowel movement
DX: XR –> air in wall of bowel
TX: NPO + abx (can use TPN for feeding)
–> surgery (f/u short gut)
Causes of failure to pass meconium
1) imperforate anus
2) meconium ileus
3) Hirschbrungs
Imperforate anus
associated with VACTERL
DX: crosstable XR + f/u on VACTERL abnormalities with U/S sacrum, echo, catheter
TX: mild –> fix now, severe –> colostomy now, fix later
Meconium ileus
CF –> decreased H2O in bowel lumen
DX: XR –> transition point with gas filled plug
TX: Water enema
f/u sweat chloride test + ADEK, pancreatic enzymes + pulm tests
Enterobius verbicularis (pinworm)
perianal pruritis, especially at night
-vulvovaginal sx may be presenting sx in prepubertal girls
DX: tape test
TX: albendazole or pyrantel pamoate
Complete AV septal defect (CAVSD)
most common congenital heart defect in patients with down sydome
–> failure of endocardial cushions to merge –> ASD + VSD
SX: diaphoresis/dyspnea with feeds
- loud S2 due to pulmonary HTN
- systolic ejection murmur (increased flow across pulm valve from ASD)
- holosystolic murmur of VSD
Etiologies of pediatric stroke
- sickle cell disease ** Most common
- prehtrombotic disorders
- congenital cardiac disease
- bacterial meningitis
- Vasculitis
- Focal cerebral arteriopathy
- Head/neck trauma
Diamond-Blackfan Syndrome (DBS)
aka congenital hypoplastic anemia
- MACROcytic anemia, low retic count (NO hypersegmented neutrophils like you would see in B12)
- congenital anomalies
-defect of erythroid progenitor cells which results in increased apoptosis
Wiskott-Aldrich syndrome
X linked disorder characterized by eczema, thrombocytopenia, and hypogammaglobulinemia
Fanconi’s anemia
AR defect in DNA chromosomal break repair
1) Aplastic anemia + progressive BM failure
2) Short stature, microcephaly, abnormal thumbs, hypogonadism
3) hypopigmented / hyperpigmented areas + cafe au lait spots and large freckles
4) strabismus, low set ears, middle ear problems (Deafness)
5) predisposition to developing cancer
Choanal atresia
suspected with newborn cyanosis aggravated by feeding, relieved by crying
*congenital nasal malformation caused by failure of nasal passage to cannalize
CHARGE syndrome - Coloboma, Heart Defects, Atresia choanae, Retardation of growth/development, GU anomalies, Ear abnormalities (deafness)
Nephrotic syndromes (4)
1) Minimal change disease (peds)
2) FSGS
3) Membranous nephropathy
4) Membranoproliferative glomerulonephritis
Nephritic syndrome
1) Post strep glomerulonephritis (peds)
2) Hemolytic uremic syndrome (peds)
3) IgA nephropathy
4) Mebranoproliferative glomerulonephritis
5) crescentic glomerulonephritis
TX: hematopoietic stem cell transplantation
Hirschbrung’s
DX?
SX?
TX?
failure of migration of inhibitory neurons –> auerbach/meissner’s plexus of DISTAL colon
DX:
-XR (normal colon distended)
-bx –> no plexus
-contrast enema or anometral manometry also works
SX: failure to pass meconium in 48hrs w/explosive stool on DRE
TX: surgical resection
Voluntary holding
pain, embarrassment causes kid to hold in stool
-voluntary holding –> overflow incontinence
DX: clinical
TX: behavioral, stool softeners, disimpaction
Causes of bilious emesis (4)
1) Malrotation
2) Duodenal atresia
3) Annular pancreas
4) Intestinal atresia
Causes of non-bilious emesis (2)
1) tracheoesophageal fistula
2) pyloric stenosis
Malrotation
failure of rotation with an otherwise normal uterine course (no polyhydramnios, no DS)
DX: XR (UGI series) –> DOUBLE BUBBLE, nml gas pattern beyond
TX: NG tube –> decompress bowel, and then surgery
f/u: volvulus
Duodenal atresia
failure of duodenum to recanalize
associated with DS
DX: XR with DOUBLE BUBBLE + NO gas distally
TX: surgery
Annular pancreas
failure of apoptosis of pancreas
associated with DS
DX: XR with DOUBLE BUBBLE + no gas distally
Intestinal atresia
vascular accidents in utero
DX: XR with double bubble and multiple air fluid levels
TX: surgery
f/u: short gut
Tracheoesophageal fistula
blind pouch +/- fistula
Day 1 presents with nonbiliary emesis
DX: NG tube coild on XR
TX: parenteral nutrition and surgery
Pyloric stenosis
hypertrophy of pyloris –> gastric outlet obstruction
presents in males around 2-8wks
SX:
- PROJECTILE, nonbilious vomit
- olive like mass
- visible peristaltic waves
DX: US –> “donut sign”
TX: pyloromyotomy
f/u: metabolic abnormalities: hypochloremic, hypokalemic, metabolic acidosis 2/2 vomiting
*give fluids before surgery
Direct bilirubin (conjugated)
charged, water soluble
excreted/trapped in urine –> DARK URINE
CANNOT cross BBB or cell membranes, and thus CANNOT get kernicterus
Indirect bilirubin (unconjugated)
fat soluble
NOT excreted in urine –> no dark urine
crosses BBB –> KERNICTERUS
Name the cause of the hyperbili:
1) + coombs
2) - coombs, low hgb
3) - coombs, high hgb
4) - coombs, nml hgb, increased retic count
5) - coombs, nml hgb, nml retic
1) + coombs = isoimmunization
2) - coombs, low hgb = hemorrhage (cephalohematoma)
3) - coombs, high hgb = transfusion (twin-twin, delayed clamping, maternal)
4) - coombs, nml hgb, increased retic count = hemolysis (G6PD, pyruvate kinase deficiency, HgbSS)
5) - coombs, nml hgb, nml retic = problem with reabsorption (breast milk jaundice vs. breast feeding jaundice)
breast milk jaundice
can present many months later
- breast milk component inhibits conjugation of bilirubin
- -> use hydrolyzed formula
breast feeding jaundice
presents in first day of life
-also have sx of dehydration
problem with quantity of breast milk –> decreased bowel function and increased absorption of bili
Causes of unconjugated hyper bili
hemolysis or hemorrhage
causes of mixed hyper bili
Crigler Najar, Gilberts –> problem with uptake
Dubin Johnson, Rotors –> problem with excretion
Hepatitis