Med Again Flashcards

1
Q

When should fleicanide be avoided ?

A

Anti-arrhythmic drug that should be avoided in patients with structural heart abnormalities

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2
Q

MOA of digoxin

A

slows the atrioventricular node in atrial fibrillation

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3
Q

No periods at 16 - first line test ?

A

FSH and LH levels

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4
Q

23 year old female, difficulty losing weight, acanthosis nigricans and alopecia, increasing amounts of hair on her upper lip and beneath the umbilicus, periods are less frequent

A

Polycystic ovarian syndrome

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5
Q

Diagnostic test for acromegaly

A

Oral glucose tolerance test

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6
Q

What cells produce insulin ?

A

Beta cells

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7
Q

What do delta cells produce ?

A

Somatostatin

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8
Q

What cells produce glucagon ?

A

Alpha cells

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9
Q

How is glucagon converted to glucose ?

A

Glycogen binds to liver receptors.
Stimulates glycogen phosphorylase to convert glucagon to glucose

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10
Q

How is RR affected in DKA

A

Increased

Rapid, deep breathing in DKA = Kussmaul breathing

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11
Q

Initial investigation for primary hyperaldosteronism ?

A

Aldosterone:renin ratio

Screening test -

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12
Q

High blood pressure, low potassium

A

Investigate Conn’s syndrome

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13
Q

What is allodynia ?

A

Heightened sensitivity to pain

(associated with neuropathy)

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14
Q

Anti-thyroglobulin antibodies

A

Hashimoto’s

(also Grave’s)

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15
Q

Why does low aldosterone cause hypotension ?

A

Reduced sodium reabsorption

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16
Q

Gliclazide MOA

A

Depolarises islet cells which increases insulin release

17
Q

SGLT2 inhibitor MOA

A

Increases urinary excretion of glucose

18
Q

Sitagliptin MOA

A

DPP4 inhibitor which prevents GLP-1 breakdown thereby increasing insulin release

19
Q

Cells found in red bone marrow

A

Mesenchymal and haematopoietic stem cells

20
Q

Main component of inorganic bone extracellular matrix (ECM)

A

Hydroxyapatite

(also the main inorganic component of dentine)

21
Q

Definition of osteomalacia

A

Osteopenia with disordered calcification leading to a higher proportion of osteoid (unmineralised) tissue after epiphyseal closure

22
Q

Effect of parathyroid hormone on kidneys

A

Blocks reabsorption of phosphate, promotes calcium reabsorption

23
Q

Serum calcium increases - what happens to serum phosphate ?

A

Decreases as it binds to calcium

24
Q

What cells break down bone tissue ?

A

Osteoclasts

25
Q

Main role of organic bone ECM

A

Provides mechanical support to bone cells

26
Q

Blood test results - Paget’s disease

A

Raised ALP, normal calcium, normal phosphate

27
Q

During exercise, how is more oxygen delivered to skeletal muscle ?

A

Decrease in blood pH in the skeletal muscle = haemoglobin has lower affinity for oxygen

28
Q

Glossopharyngeal nerve exits skull via the …

A

Jugular foramen

29
Q

nervesWhich nerve information about hearing from the inner ear?

A