Mechanisms of Disease

Question 1

What does VINDICATE stand for?

Answer 1

Vascular, infectious/inflammatory, neoplastic, drugs/toxins, intervention/iatrogenic, congenital/developmental, autoimmune, trauma and endocrine/metabolic

Question 2

What effect of disease does VINDICATE not include?

Answer 2

Psychological/psychiatric - but still very important

Question 3

What are the components of vascular effects on disease?

Answer 3

Blood vessels - inflammation, clots and blockages

Question 4

What is neoplasia?

Answer 4

New growth eg cancer etc

Question 5

What is iatrogenic in relation to?

Answer 5

Caused by the doctor

Question 6

What is a congenital defect?

Answer 6

Something the person is born with - more likely to affect babies

Question 7

What is endocrine disease affected by?

Answer 7

Hormones

Question 8

What is gross pathology?

Answer 8

Dissection of resection specimens looking at gross features of disease

Question 9

What is microscopic pathology?

Answer 9

A systematic approach - is it abnormal? what kind of process is it (VINDICATE)? and look at the specific features of the disease

Question 10

What is autopsy pathology?

Answer 10

Answers questions. Cause of death, confirmation of cancer type, inherited disease, treatment complication, assess effect of frug, accurate classification of infectious disease and public health issues

Question 11

Why is histology important?

Answer 11

‘Normal’ must be understood before you can begin to understand the disease (abnormal)