Mechanisms of action

Question 0

1. What is percentage of d2 receptors that need to be blocked for suppression of positive symptoms?
2. What is the percentage of d2 receptors that need to be blocked to have symptoms of eps?

Answer 0

1. At least 69-65%

2. More than 77%

Question 1

What are the 3 categories of antipsychotics and how do they differ from each other?

Answer 1

1. Typical or Traditional - high d2 antagonism and low 5hta2 antagonism
2. Atypical - moderate to high d2 and high 5hta2 Antagonism
3. Clozapine like - low d2 and high 5 hta2 antagonism
   All have higher 5hta2 antagonism than d2 except arpiprazole

Question 2

Which antipsychotic has the lowest d2 binding?

Answer 2

Quietapine

Question 3

Which part of the brain is the primary effect/action of antipsychotics?

Answer 3

Limbic system

Question 4

What is possible mechanism of alleviating negative symptoms by antipsychotics?

Answer 4

The blockage of 5ht and d2 receptors lead to an increase in dopamine release in the prefrontal cortex.