Mechanisms/Drug Classes Flashcards
What is the mechanism of action of the inhibitors of thymidylate synthase?
Inhibition of thymidylate synthase, which decreases cellular availability of dTMP and causing “thymineless” cell death
Fluorouracil (5-FU)
Inhibitor of thymidylate synthase
Capecitabine
Inhibitor of thymidylate synthase
Pemetrexed
Inhibitor of thymidylate synthase
What is the mechanism of action of the inhibitors of purine metabolism?
Drug metabolites inhibit IMPDH and other synthetic enzymes, interfering with AMP and GMP synthesis
6-Mercaptopurine (6-MP)
Inhibitor of purine metabolism
azathiprine
Inhibitor of purine metabolism
Pentostatin
Inhibitor of purine metabolism
What is the mechanism of action of the inhibitors of ribonucleotide reductase?
Inhibition of ribonucleotide reductase, the enzyme that converts ribonucleotides to deoxyribonucleotides, which inhibits DNA synthesis
hydroxyurea
inhibitor of ribonucleotide reductase
What it the mechanism of action of purine and pyrimidine analogues that are incorporated into DNA?
Incorporation into DNA and RNA results in inhibition of DNA polymerase, causing cell death
thioguanine
Guanine analogue
fludarabine phosphate
fluorinated purine nucleotide analogue
Cladribine
adenosine analogue
cytarabine (araC)
Cytidine analogue
5-Azacytidine
Cytidine analogue
decitabine
Cytidine analogue
gemcitabine
Fluorinated cytidine analogue
What is the mechanism of action of alkylating agents (agents that directly modify DNA structure)?
They covalently bind DNA, often cross-link to DNA or associated proteins
mechlorethamine
Alkylating agent