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Pharmacology Chapter 28 > Mechanisms/Drug Class > Flashcards

Mechanisms/Drug Class Flashcards

1
Q

what is the MoA of glucocorticoid receptor agonists

A

mimic cortisol function by acting as agonists at the glucocorticoid receptor

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2
Q

prednisone

A

glucocorticoid rec agonist

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3
Q

prednisolone

A

glucocorticoid rec agonist

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4
Q

methylprednisolone

A

glucocorticoid rec agonist

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5
Q

dexamethasone

A

glucocorticoid rec agonist

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6
Q

hydrocortisone

A

glucocorticoid rec agonist

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7
Q

fluticasone

A

glucocorticoid rec agonist

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8
Q

beclomethasone

A

glucocorticoid rec agonist

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9
Q

flunisolide

A

glucocorticoid rec agonist

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10
Q

triamcinolone

A

glucocorticoid rec agonist

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11
Q

budesonide

A

glucocorticoid rec agonist

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12
Q

what is the MoA of glucocorticoid rec antagonists

A

competitive antagonist of cortisol action at the glucocorticoid receptor

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13
Q

mifepristone (RU-486)

A

glucocorticoid receptor antagonist

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14
Q

what in the MoA of inhibitor of glucocorticoid synthesis

A

inhibit various steps in glucocorticoid hormone biosynthesis

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15
Q

mitotane

A

inhibitor of glucocorticoid synthesis

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16
Q

aminoglutethimide

A

inhibitor of glucocorticoid synthesis

17
Q

metyrapone

A

inhibitor of glucocorticoid synthesis

18
Q

trilostane

A

inhibitor of glucocorticoid synthesis

19
Q

ketoconazole

A

inhibitor of glucocorticoid synthesis

20
Q

what is the MoA of meneralocorticoid rec agonists?

A

agonist at mineralocorticoid receptor

21
Q

fludrocortisone

A

mineralocorticoid rec agonist

22
Q

what is the MoA of mineralocorticoid rec antagonist

A

competitive antagonist of aldosterone action at the mineralocorticoid rec

23
Q

spironolactone

A

collecting duct/K+ sparing diuretic and mineralocorticoid rec antagonist

24
Q

eplerenone

A

collecting duct/K+ sparing diuretic and mineralocorticoid rec antagonist

25
Q

what is the MoA of adrenal sex steroids

A

DHEA is a prohormone converted to testosterone in the periphery

26
Q

dehydroepiandrosterone DHEA

A

adrenal sex steroid

Pharmacology Chapter 28 (1 decks)

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