Mechanisms/Drug Class

Question 1

What is the mechanism of action of GH and Insulin-like growth factor replacement?

Answer 1

Stimulate release of or replace growth hormone or insulin-like growth factor

Question 2

somatropin

Answer 2

growth hormone

Question 3

somatrem

Answer 3

growth hormone replacement

Question 4

mecasermin

Answer 4

recombinant IGF-1

Question 5

What is MoA of agent that decrease GH secretion or action

Answer 5

inhibit GH release or antagonize GH receptor

Question 6

ocreotide

Answer 6

inhibit GH release

Question 7

pegvisomant

Answer 7

antagonize GH receptor

Question 8

What is the MoA of agents that decrease prolactin levels?

Answer 8

inhibit pituitary prolactin release

Question 9

bromocriptine

Answer 9

inhibit prolactin release

Question 10

cabergoline

Answer 10

inhibit prolactin release

Question 11

what is the MoA of agents that test thyroid function or stimulate iodide uptake

Answer 11

act as TRH, TSH

Question 12

protirelin

Answer 12

TRH, to dx thyroid function

Question 13

thyrotropin

Answer 13

TSH, stimulate iodide uptake in tx thyroid cancer

Question 14

cosyntropin

Answer 14

ACTH 1-24, dx adrenocortical function

Question 15

what is the MoA of agents that alter gonadotropin expression and alter gonadal maturation

Answer 15

some are GnRH analogues, some GnRH antagonists

Question 16

gonadorelin

Answer 16

GnRH analog; continuous inhibits LH and FSH; pulsatile stimulates LH and FSH release

Question 17

leoprolide, goserelin, histrelin, nagarelin

Answer 17

GnRH analog; continuous inhibits LH and FSH; pulsatile stimulates LH and FSH release

Question 18

ganirelix, cetrorelix

Answer 18

GnRH rec antagonist

Question 19

follitropin

Answer 19

rFSH

Question 20

Urofollitropin

Answer 20

FSH

Question 21

what is the MoA of vasopressin antagonists

Answer 21

mixed V1/V2 rec antagonists

Question 22

conivaptan, tolvaptan

Answer 22

mixed V1/V2 rec antagonists