Mechanisms/Drug Class Flashcards by Melissa V | Brainscape

Q

What is the mechanism of action of μ-opioid receptor agonists?

A

Natural or semisynthetic agonists of the μ-opiod receptor that result in inhibition of neurotransmission

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Q

morphine

A

μ-opioid receptor agonist

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Q

codeine

A

μ-opioid receptor agonist

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Q

oxycodone

A

μ-opioid receptor agonist

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Q

hydrocodone

A

μ-opioid receptor agonist

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Q

tramadol

A

μ-opioid receptor agonist

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Q

What is the mechanism of action of synthetic μ-opioid receptor agonists?

A

Synthetic agonists of the μ-opioid receptor that result in the inhibition of neurotransmission

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Q

methadone

A

synthetic μ-opioid receptor agonist

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Q

fentanyl

A

synthetic μ-opioid receptor agonist

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Q

alfentanil

A

synthetic μ-opioid receptor agonist

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Q

sufentanil

A

synthetic μ-opioid receptor agonist

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Q

remifentanil

A

synthetic μ-opioid receptor agonist

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Q

meperdine

A

synthetic μ-opioid receptor agonist

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Q

levorphanol

A

synthetic μ-opioid receptor agonist

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Q

propoxyphene

A

synthetic μ-opioid receptor agonist

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Q

butorphanol

A

partial μ-opioid receptor agonist

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Q

buprenorphine

A

partial μ-opioid receptor agonist

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Q

nalbuphine

A

k-agonist with partial μ-antagonist activity

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Q

What is the mechanism of action of the partial μ-opioid receptor antagonists?

A

Antagonists of the partial μ-opiod receptor, thereby blocking endogenous or exogenous opioid effects

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Q

naloxene

A

μ-opioid receptor antagonist

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Q

naltrexone

A

μ-opioid receptor antagonist

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Q

alvimopan

A

μ-opioid receptor antagonist

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Q

methylnaltrexone

A

μ-opioid receptor antagonist

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Q

What is the mechanism of non steroidal analgesics?

A

They affect prostaglandin synthesis pathway

Q

acetaminophen

A

nonsteroidal analgesic

Q

aspirin

A

nonsteroidal analgesic

Q

naproxen

A

nonsteroidal analgesic

Q

ibuprofen

A

nonsteroidal analgesic

Q

indomethacin

A

nonsteroidal analgesic

Q

diclofenac

A

nonsteroidal analgesic

Q

piroxicam

A

nonsteroidal analgesic

Q

celecoxib

A

nonsteroidal analgesic

Q

diclofenac

A

nonsteroidal analgesic

Q

ketorolac

A

nonsteroidal analgesic

Q

What is the mechanism of action of tricyclic antidepressants?

A

They promote serotenergic and noradrenergic neurotransmission by inhibiting neurotransmitter reuptake

Q

amitriptyline

A

tricyclic antidepressant

Q

nortriptyline

A

tricyclic antidepressant

Q

imipramine

A

tricyclic antidepressant

Q

despiramine

A

tricyclic antidepressant

Q

duloxetine

A

tricyclic antidepressant

Q

venlafaxine

A

tricyclic antidepressant

Q

What is the mechanism of action of antiepileptic drugs and antiarrhthmics?

A

They inhibit action potential initiation or conduction

Q

carbamezepine

A

antiepileptic/antiarrthmic

Q

oxycarbazepine

A

antiepileptic/antiarrthmic

Q

gabapentin

A

antiepileptic/antiarrthmic

Q

pregabalin

A

antiepileptic/antiarrthmic

Q

lamotrigine

A

antiepileptic/antiarrthmic

Q

mexiletine

A

antiepileptic/antiarrthmic

Q

What is the mechanism of action of the NMDA receptor antagonists?

A

They block NMDA receptor-dependent postsynaptic depolarization

Q

ketamine

A

NMDA receptor antagonist

Q

dextromethorphan

A

NMDA receptor antagonist

Q

What is the mechanism of action of 5-HT serotinin receptor agonists?

A

They induce cerebrovascular vasoconstriction, reduce nociceptive transmission

Q

sumatriptan

A

5-HT receptor agonist

Q

rizatriptan

A

5-HT receptor agonist

Q

naratriptan

A

5-HT receptor agonist

Q

zolmitriptan

A

5-HT receptor agonist

Q

almotriptan

A

5-HT receptor agonist

Q

eletriptan

A

5-HT receptor agonist