Mechanisms/Drug Class Flashcards by Melissa V

Q

What is the mechanism of action of μ-opioid receptor agonists?

A

Natural or semisynthetic agonists of the μ-opiod receptor that result in inhibition of neurotransmission

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Q

morphine

A

μ-opioid receptor agonist

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Q

codeine

A

μ-opioid receptor agonist

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Q

oxycodone

A

μ-opioid receptor agonist

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Q

hydrocodone

A

μ-opioid receptor agonist

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Q

tramadol

A

μ-opioid receptor agonist

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Q

What is the mechanism of action of synthetic μ-opioid receptor agonists?

A

Synthetic agonists of the μ-opioid receptor that result in the inhibition of neurotransmission

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Q

methadone

A

synthetic μ-opioid receptor agonist

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Q

fentanyl

A

synthetic μ-opioid receptor agonist

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Q

alfentanil

A

synthetic μ-opioid receptor agonist

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Q

sufentanil

A

synthetic μ-opioid receptor agonist

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Q

remifentanil

A

synthetic μ-opioid receptor agonist

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Q

meperdine

A

synthetic μ-opioid receptor agonist

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Q

levorphanol

A

synthetic μ-opioid receptor agonist

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Q

propoxyphene

A

synthetic μ-opioid receptor agonist

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Q

butorphanol

A

partial μ-opioid receptor agonist

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Q

buprenorphine

A

partial μ-opioid receptor agonist

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Q

nalbuphine

A

k-agonist with partial μ-antagonist activity

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Q

What is the mechanism of action of the partial μ-opioid receptor antagonists?

A

Antagonists of the partial μ-opiod receptor, thereby blocking endogenous or exogenous opioid effects

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Q

naloxene

A

μ-opioid receptor antagonist

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Q

naltrexone

A

μ-opioid receptor antagonist

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Q

alvimopan

A

μ-opioid receptor antagonist

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Q

methylnaltrexone

A

μ-opioid receptor antagonist

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Q

What is the mechanism of non steroidal analgesics?

A

They affect prostaglandin synthesis pathway

acetaminophen

nonsteroidal analgesic

aspirin

nonsteroidal analgesic

naproxen

nonsteroidal analgesic

ibuprofen

nonsteroidal analgesic

indomethacin

nonsteroidal analgesic

diclofenac

nonsteroidal analgesic

piroxicam

nonsteroidal analgesic

celecoxib

nonsteroidal analgesic

diclofenac

nonsteroidal analgesic

ketorolac

nonsteroidal analgesic

What is the mechanism of action of tricyclic antidepressants?

They promote serotenergic and noradrenergic neurotransmission by inhibiting neurotransmitter reuptake

amitriptyline

tricyclic antidepressant

nortriptyline

tricyclic antidepressant

imipramine

tricyclic antidepressant

despiramine

tricyclic antidepressant

duloxetine

tricyclic antidepressant

venlafaxine

tricyclic antidepressant

What is the mechanism of action of antiepileptic drugs and antiarrhthmics?

They inhibit action potential initiation or conduction

carbamezepine

antiepileptic/antiarrthmic

oxycarbazepine

antiepileptic/antiarrthmic

gabapentin

antiepileptic/antiarrthmic

pregabalin

antiepileptic/antiarrthmic

lamotrigine

antiepileptic/antiarrthmic

mexiletine

antiepileptic/antiarrthmic

What is the mechanism of action of the NMDA receptor antagonists?

They block NMDA receptor-dependent postsynaptic depolarization

ketamine

NMDA receptor antagonist

dextromethorphan

NMDA receptor antagonist

What is the mechanism of action of 5-HT serotinin receptor agonists?

They induce cerebrovascular vasoconstriction, reduce nociceptive transmission

sumatriptan

5-HT receptor agonist

rizatriptan

5-HT receptor agonist

naratriptan

5-HT receptor agonist

zolmitriptan

5-HT receptor agonist

almotriptan

5-HT receptor agonist

eletriptan

5-HT receptor agonist