Mechanism of Disease Flashcards
Athersclerosis (obliterans)
most common arterial pathology
thickening, hardening, loss of elasticity of the artery walls
Athersclerosis (obliterans)
changes occur in
intima and media layer of the vessels
Athersclerosis (obliterans)
major risk factors
- smoking
- hyperlipidemia
- family hx
Athersclerosis (obliterans)
less important factors
- htn
- diabetes
- sedentary lifestyle
- arterial wall shear/stress
Athersclerosis (obliterans)
most common sites
- carotid bif
- ao-iliac
- CFA bif
- SFA-distal
Athersclerosis (obliterans)
ex: leriche syndrome caused by
obstruction of the ao
occurs in males
Athersclerosis (obliterans)
ex: leriche syndrome characterized by
- fatigue in hips
- thighs or calves with exercise
- impotence
- often times, pallor and coldness of LE
Embolism
obstruction of vessel by
foreign substance or blood clot
emobli may by
solid, liquid or gaseous
embolism
most frequent cause
small plaque breaks loose travels distally until it lodges in smallest vessels
embolism
ex:
blue toe syndrome (trash foot)
emoblism
toe ischemia results
often improve because of collateralized branches
Aneurysm
true aneurysm is dilatation of
all three arterial wall layers
Aneurysm
fusiform
diffuse, circumferential dilatation
Aneurysm
saccular
localized sac like
Aneurysm
dissecting happens when a
small tear of the inner wall allows blood to form cavity between two wall layers
*often occurs in thoracic ao