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QUESTIONS ECEIM 1 > Mechanism Of Action Drugs > Flashcards

Mechanism Of Action Drugs Flashcards

1
Q

TMPS

A

Inhibition DNA synthesis by interfering on folate pathway

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2
Q

Fluoroquinolones

A

Inhibition DNA synthesis by interfering on DNA gyrase

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3
Q

Macrolides

A

Inhibitiln of dna synthesis by interfering on RNA polymerasa

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4
Q

Metromidazol

A

Creates free radicals inside bacteria

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5
Q

BLactams

A

Interfere on cell wall synthesis: Act on ezymes called penicillin binding proteins (PBPs) and it produces a lysisnof the cell

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6
Q

Tetracyclines

A

Inhibition of protein synthesis: act on 30s ribosome

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7
Q

Aminoglycosides

A

Inhibition of protein synthesis: act on 30s ribosome

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8
Q

Macrolides

A

Inhibition of protein synthesis: act on 50s ribosome

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9
Q

Cloramohenicol

A

Inhibition of protein synthesis: act on 50s ribosome

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10
Q

Pergolide

A

Dopamine D2 agonist

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11
Q

Bromocriptine

A

Dopamine D2 agonist

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12
Q

Cabergoline

A

Dopamine D2 agonist

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13
Q

Ciproheptadine

A

Serotonine antagonist, treatement of PPId

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14
Q

Metformine

A

AMPK agonist, helping entering glucose into the cells
Reduces glucose and insuline levels
Low bioavailability

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15
Q

Levothyroxine

A

Synthetic T4: same action than thyroid hormones: increases gluconeogenesis, protein synthesis, mobilization glycogen stores = increases metabolic rate in the cells

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16
Q

Pentoxifiline

A

Phosphodiesterasa (pde) inhibitor

cAMP —(pde)——>5AMP —-> secretion cytokines

AE: decreases blood viscosity

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17
Q

DMSO

A

Scavenge derived radicals

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18
Q

Polymyxin B

A

Binds lipid A portion of LPS and neutralizes endotoxin capacity

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19
Q

Lidocaine

A

Block Na channels

AE: muscle fasciculations, ataxia, seizure

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20
Q

Bethanecol

A

Parasympathicomymetic acting smooth muscle throw muscarinic receptors
Muscarinic cholinergic agonist- stimulates ACh receptors

AE: cholinergic effects: abdominal pain, sweating, salivation

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21
Q

Mitomycin C

A

Decreases collagen cross linking and inhibits fibroblast proliferation

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22
Q

Neostigmine

A

Inhibition cholinesterasa, increasing levels of Ach binding to muscarining receptors

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23
Q

Metroclopramide

A

5HT-4 agonist
5HT-3 antagonist
Dopamine antagonist

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24
Q

Cisapride

A

5HT-4 agonist

5HT-3 antagonist

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25
Q

Domperidone

A

Antagonist D2 receptors

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26
Q

Erythromycin

A

Motilin receptor agonist

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27
Q

Acepromazine

A

Dopamine receptor antagonist

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28
Q

Furosemide

A

Na/K/Cl pump inhibitor in the ascending loop henle

AE: hypokalemia, hyponatremia, hypocloremia ans hypomagnesemia.
It increases digoxin toxicity effects

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29
Q

ACE inhibitors (benazepril)

A

Inhibits RAAS system

ACE inhibitors avoid conversion of AT1 to AT2

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30
Q

Digoxin

A

Inhibits na/kATPase pump: causing na to accumulate into the cell preventing calcium to go out too fast from the cell. Allowing more calcium available to be released from the sarcoplasmatic reticulum, enhancing contraction

AE: colic, diarrhea, anorexia, arritmias

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31
Q

Aspirin

A

Irreversible inhibits COX in platelets, inhibiting gormation thromboxane

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32
Q

Acetaminophen

A

Mild effect on COX. Acts on Serotonergic and cabbinoid pathways

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33
Q

Ketamine

A

NMDA antagonist

34
Q

Tramadol

A

Seritonine antagonist and u agonist

35
Q

Azathioprine

A

Is an imidazole antimetabolite that acts as a purine antagonist, competing with the synthesis of nucleic acids

36
Q

Morphine

A

U receptor agonist

37
Q

Methadone

A

U receptor agonist and NMDA antagonist

38
Q

Butorphanol

A

K agonist and u antagonist

39
Q

Corticosteroids

A

Inhibitor of phospholipase A2, inhibiting formation of arachidonic acid

40
Q

Buscopan

A

Muscarinic antagonist

41
Q

Methacarbamol

A

Works on the postsynaptic activity. It decreases nerve transmission and prolongs refrsctory period of muscle cells

42
Q

Doxapram

A

Stimulates the receptors in the carotid seno, who consequently stimulate the respiratory center

43
Q

Timolol

A

B blocker (decreases aqueus humor)

44
Q

Dorzolamide

A

Inhibitor of carbonic anhydrase

45
Q

Aciclovir/valaciclovir

A

Synthetic purine nucleoside analog that selective inhibits replication EHV

46
Q

Acetylcysteine

A

Rupting disulfide bonds in mucoprotein molecules, reducing mucus viscosity

47
Q

MgSO4

A

Ca channel blocker and activator if the na/k atpase

48
Q

Deferoxamine

A

Inhibits cell iron uptake

49
Q

Heparin

A

Binds reversibly to antithrombin 3 and accelerates the inactivation of coagulation at the level of the factor 2 and 10

50
Q

Aminocaproic and tranaxemic acid

A

Inactivates plasmin (antifibrinolytic)

51
Q

Clopidogrel (antiplatelet medication)

A

Inhibits ADP receptors

52
Q

Psyllium

A

Increases production of SCFAs in the colon

53
Q

Misoprostol

A

Protaglandin analogue and prodtanoid antagonist

54
Q

Benzodiazepine

A

Binds GABA receptors

55
Q

Phenobarbital

A
  • facilitates the effect of GABA
  • potentiates glutamate
  • blocks ca channel
56
Q

Phenitoine

A

Blocks Na channels, prevents glutamate release

57
Q

Salbutamol, albuterol, clenbuterol

A

B2 agonist

58
Q

Ipatropium

A

Anticholinergic bronchodilator

59
Q

Sodium chromoglycate (for asthma)

A

Mast cell stabilizer it blocks ca channel inhibiting release of histamine

60
Q

Gallium (for rhodo treatement)

A

Inactivation of iron blocking dna synthesis

61
Q

Dantrolene

A

Decreases frequency of ca channel opening, Blockyng RYR R

62
Q

Fluohenazine

A

Blocks dopamine receptors

63
Q

Hydralazine

A

Smooth muscle relaxant - vasodilator primarly of arterioles
-inhibition of inositol triphosphate induces calcium release in the Sarcoplasmatic reticulum in arterial smooth muscle cells

64
Q

Amiloride (for congestice heart failure)

A

Potassium-sparing diuretic

Na channel blocker in the convoluted distal tubule and collecting duct

65
Q

Spironolactone

A

Block type 1 mineralocorticoid/glucocorticoid receptors (aldosterone antagonist)

66
Q

Thiazide diuretic

A

Blocks na/cl in the distal convulted tubule

67
Q

Type I antiarrythmic

A

Block fast sodium channel

1a quinidine and procainamide
1b lidocaine and phenitoime
1c propafenone and flecainide

68
Q

Class 2 antiarrythmic

A

B1 blocker

Propanolol and solatolol

69
Q

Class 3 antiarrythmics

A

k channel blocker

Amiodorone and bretylium

70
Q

Noradrenaline

71
Q

Phenilephrine

72
Q

Dopamine

A

X1, b1, b2 et d receptors

73
Q

Dobutamine

74
Q

Yohimbine

A

Alpha2 antagonist

75
Q

Tpa

A

Converts inactive plasminogen to plasmin

76
Q

Naloxone

A

U opioid receptor antagonist

77
Q

Alvimopan

A

U opioid receptor antagonist

Prokinetics effects

78
Q

Tegaserod

A

5HT4 agonist

79
Q

Metformine

A

Ampk agonist

80
Q

Digoxin

A

Cardiac glycoside

It works keeping calcium in the cell and increasing contraction,
Inhibits Na/K atpase and then na stays in the cell and so calcium doesnt go out w the calcium/na pump.

It also decreases HR affecting the vagus nerve

QUESTIONS ECEIM 1 (3 decks)

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