Mechanism of Action / Class

Question 1

Factor Xa inhibitors

Answer 1

Rivaroxaban
Apixaban
Edoxaban

Question 2

Inhibits factor II, VII, IX, and X

Answer 2

Warfarin

Question 3

Direct thrombin inhibitors

Answer 3

IV - argatroban, Bivalirudin

PO - dabigatran

Question 4

Unfractionated Heparin

Answer 4

Increases antithrombin (AT) activity to have anti-Factor Xa and anti-Thrombin IIa activity

AT inactivates factor iia and factor Xa

Question 5

Indirect Factor Xa inhibitor

Answer 5

Fondaparinux

Question 6

Dalteparin

Answer 6

Increase anti-thrombin (AT) activity to have MORE anti-factor-Xa than anti-thrombin-IIa

AT inactivates thrombin (factor IIa) and factor Xa

Question 7

Warfarin

Answer 7

Vitamin K antagonist that blocks required cofactors for carboxylation (activation) clotting factors like II, IV, IX, and X

Question 8

Fondaparinux

Answer 8

Bind to antithrombin (AT) to inactivate Factor Xa

Question 9

Dabigatran

Answer 9

Direct thrombin inhibitor - decreases the amount of fibrin available for a clot formation

Question 10

Which anticoagulants are high alert medications?

Answer 10

ALL ANTICOAGULATIONS ARE HIGH ALERT MEDICATIONS

Question 11

Protamine sulfate

Answer 11

Binds to acidic heparin to form a stable salt complex

Question 12

Idarucizumab

Answer 12

Praxbind reversal agent for Pradaxa (Dabagatran)

Question 13

Andexxa

Answer 13

Andexanet alfa
reversal agent for Rivaroxaban (Xarelto) and Apixaban (Eliquis)

Question 14

Phenytonadione (Mephton)

Answer 14

Vitamin K reversal agent for Warfarin

Question 15

Kcentra

Answer 15

Four factor prothrombin complex concentrate contains Factors II, VII, IX, X, protein C and S to reverse warfarin action