Mechanism of Action and class Flashcards
inhibitors of murein monomer synthesis
varies by drug
fosfomycin
inhibitors of murein monomer synthesis - phosphoenolpyruvate analog that inhibits bacterial enol pyruvate transferase by covalent modification of enzymes active site to inhibit UDP-NAM -> UDP-NAG
fosmidomycin
inhibitors of murein monomer synthesis - phosphoenolpyruvate analog that inhibits bacterial enol pyruvate transferase by covalent modification of enzymes active site to inhibit UDP-NAM -> UDP-NAG
cycloserine
inhibitors of murein monomer synthesis - inhibits both alanine racemase and D-ala-d-ala ligase
bacitracin
inhibitors of murein monomer synthesis - inhibits dephosphorylation of bactoprenyl diphosphate
what is the MoA of inhibitors of murein polymer synthesis
bind to the D-ala-d-ala terminus of the murein monomer unit and inhibit peptidoglycan glycosyltransferase (PGT) to prevent addition of murein units to growing polymer chain
vancomycin
inhibits murein polymer synthesis
telavancin
inhibits murein polymer synthesis
teicoplanin
inhibits murein polymer synthesis
what is the MoA of inhibitors of polymer crosslinking penicillins
beta-lactams inhibit transpeptidase by forming a covelent dead-end acyl enzyme intermediate; PCN have a 5 member accesory ring attached to the beta-lactam ring
penicillin G
penicillin, IV form
penicillin V
penicillin, oral form
oxacillin
penicillin (beta-lactamase resistant)
cloxacillin
penicillin (beta-lactamase resistant)
dicloxacillin
penicillin (beta-lactamase resistant)
nafcillin
penicillin (beta-lactamase resistant)
ampicillin
penicillin, broad spectrum
amoxicillin
penicillin, broad spectrum
amoxicillin/clavulanic acid
penicllin, broad spectrum/beta lactamase inhibitor