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Pharmacology Chapter 34 > Mechanism of Action and class > Flashcards

Mechanism of Action and class Flashcards

1
Q

inhibitors of murein monomer synthesis

A

varies by drug

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2
Q

fosfomycin

A

inhibitors of murein monomer synthesis - phosphoenolpyruvate analog that inhibits bacterial enol pyruvate transferase by covalent modification of enzymes active site to inhibit UDP-NAM -> UDP-NAG

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3
Q

fosmidomycin

A

inhibitors of murein monomer synthesis - phosphoenolpyruvate analog that inhibits bacterial enol pyruvate transferase by covalent modification of enzymes active site to inhibit UDP-NAM -> UDP-NAG

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4
Q

cycloserine

A

inhibitors of murein monomer synthesis - inhibits both alanine racemase and D-ala-d-ala ligase

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5
Q

bacitracin

A

inhibitors of murein monomer synthesis - inhibits dephosphorylation of bactoprenyl diphosphate

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6
Q

what is the MoA of inhibitors of murein polymer synthesis

A

bind to the D-ala-d-ala terminus of the murein monomer unit and inhibit peptidoglycan glycosyltransferase (PGT) to prevent addition of murein units to growing polymer chain

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7
Q

vancomycin

A

inhibits murein polymer synthesis

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8
Q

telavancin

A

inhibits murein polymer synthesis

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9
Q

teicoplanin

A

inhibits murein polymer synthesis

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10
Q

what is the MoA of inhibitors of polymer crosslinking penicillins

A

beta-lactams inhibit transpeptidase by forming a covelent dead-end acyl enzyme intermediate; PCN have a 5 member accesory ring attached to the beta-lactam ring

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11
Q

penicillin G

A

penicillin, IV form

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12
Q

penicillin V

A

penicillin, oral form

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13
Q

oxacillin

A

penicillin (beta-lactamase resistant)

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14
Q

cloxacillin

A

penicillin (beta-lactamase resistant)

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15
Q

dicloxacillin

A

penicillin (beta-lactamase resistant)

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16
Q

nafcillin

A

penicillin (beta-lactamase resistant)

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17
Q

ampicillin

A

penicillin, broad spectrum

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18
Q

amoxicillin

A

penicillin, broad spectrum

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19
Q

amoxicillin/clavulanic acid

A

penicllin, broad spectrum/beta lactamase inhibitor

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20
Q

ampicillin/sulbactam

A

penicllin, broad spectrum/beta lactamase inhibitor

21
Q

carbenicillin

A

penicillin, broad spectrum

22
Q

ticarcillin

A

penicillin, broad spectrum

23
Q

piperacillin

A

penicillin, broad spectrum

24
Q

mezlocillin

A

penicillin, broad spectrum

25
Q

what is the MoA of inhibitors of polymer crosslinking cephalosporins?

A

beta-lactams inhibit transpeptidase by formin covalent dead end acyl enzyme intermediate; cephalosporins have a 6 member accessory ring attached to beta lactam ring

26
Q

cefazolin

A

cephalosporin, 1st generation

27
Q

cephalexin

A

cephalosporin, 1st generation

28
Q

cefuroxime

A

cephalosporin, 2nd generation

29
Q

cefotetan

A

cephalosporin, 2nd generation

30
Q

cefoxitin

A

cephalosporin, 2nd generation

31
Q

cefotaxime

A

cephalosporin, 3rd generation

32
Q

cefrizoxime

A

cephalosporin, 3rd generation

33
Q

ceftriaxone

A

cephalosporin, 3rd generation

34
Q

cefoperazone

A

cephalosporin, 3rd generation

35
Q

ceftazidime

A

cephalosporin, 3rd generation

36
Q

cefepime

A

cephalosporin, 4th generation

37
Q

ceftaroline

A

cephalosporin, 5th generation

38
Q

what is the MoA of inhibitors of polymer cross linking monobactams/carbapenems

A

beta lactams inhibit transpeptidase forming covalent dead end acyl enzyme intermediate

39
Q

aztreonam

A

inhibits polymer crosslinking; monobactam

40
Q

imipenem/cilastatin

A

inhibits polymer crosslinking; carbapenem

41
Q

meropenem

A

inhibits polymer crosslinking; carbapenem

42
Q

doripenem

A

inhibits polymer crosslinking; carbapenem

43
Q

ertapenem

A

inhibits polymer crosslinking; carbapenem

44
Q

what is the MoA of inhibitors of cell membrane stability

A

integrates in Gram pos bacterial membranes; leading to formation of pores that cause K+ efflux, membrane depolarization and cell death

45
Q

daptomycin

A

inhibits cell membrane stability

46
Q

ethambutol

A

antimycobacterial; decreases arabinogalactan synthesis by inhibiting arabinosyl transferase that adds arabinose units to end of growing arabinogalactan chain

47
Q

pyrazinamide

A

antimycobacterial; inhibits fatty acid synthetase 1

48
Q

isoniazid

A

antimycobacterial; inhibits mycolic acid synthesis by targeting fatty acid synthetase 2

49
Q

ethionamide

A

antimycobacterial; inhibits mycolic acid synthesis by targeting fatty acid synthetase 2

Pharmacology Chapter 34 (1 decks)

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