Mechanism of Action

Question 1

Epoprostenol (Flolan)

Answer 1

Prostacyclin analogue that vasodilates to reduce PAH

***POTENT vasodilatory

Question 2

Treprostinil

Answer 2

Prostacyclin analogue that vasodilates to reduce PAH

*POTENT vasodilator

Question 3

Bosentan

Answer 3

Endothelin receptor antagonist that blocks the vasoconstrictor effects of endothelin on pulmonary arteries

Question 4

Ambrisentan

Answer 4

Endothelin receptor antagonist that blocks the vasoconstrictor effects of endothelin on pulmonary arteries

Question 5

Macitentan

Answer 5

Endothelin receptor antagonist that blocks the vasoconstrictor effects of endothelin on pulmonary arteries

Question 6

Sildenafil (revatio)

Answer 6

Phosphodiesterase-5 inhibitor increased cGMP to lead to pulmonary artery vasodilation

Question 7

Tadalafil (Adcirca)

Answer 7

Phosphodiesterase-5 inhibitor increased cGMP to lead to pulmonary artery vasodilation

Question 8

Riociguat

Answer 8

soluble guanylate cyclase stimulator (sGC) that sensitizes sGC to nitric oxide leading to increases cGMP which will cause pulmonary artery vasodilation

Question 9

QVAR RediHaler

Answer 9

Inhaled Corticosteroid that inhibits the inflammatory response

1st line for asthma

Question 10

Arnuity Ellipta

Answer 10

Inhaled Corticosteroid that inhibits the inflammatory response

1st line for asthma

Question 11

Pulmicort

Answer 11

Inhaled Corticosteroid that inhibits the inflammatory response

1st line for asthma

Question 12

Flovent

Answer 12

Inhaled Corticosteroid that inhibits the inflammatory response

1st line for asthma

Question 13

Singulair

Answer 13

Leukotriene receptor agonist that inhibits leukotriene D4 (LKD4)

Question 14

Theophylline

Answer 14

phosphodiesterase inhibitor leading to increase in cAMP to release epinephrine to dilate the broncho blood vessels

*** not very effective in asthma

Question 15

Xolair

Answer 15

Omalizumab
monoclonal antibody that inhibits IgE binding and can be used for allergic asthma