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Antifungal + Antivirals > Mechanism of Action > Flashcards

Mechanism of Action Flashcards

1
Q

Amphotericin B

A

binds to ergosterol (a fungal cell membrane component) increasing cell permeability = cell death

BROAD spectrum: histoplasma, blastomyces, coccidioides, aspergillus, candida species, crypto neoformans

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2
Q

Diflucan

A

decreased ergosterol synthesis to block cell membrane formation

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3
Q

Nizoral A-D

A

Ketoconazole
decreased ergosterol synthesis to block cell membrane formation

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4
Q

Vfend

A

Voriconazole
decreased ergosterol synthesis to block cell membrane formation

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5
Q

Noxadil

A

Posaconazole
decreased ergosterol synthesis to block cell membrane formation

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6
Q

Cancidas

A

Caspofungin
inhibits sythesis of beta (1,3)-D-glucan of the fungal cell WALL

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7
Q

Mycamine

A

Micafungin
inhibits sythesis of beta (1,3)-D-glucan of the fungal cell WALL

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8
Q

Tamiflu

A

Oseltamivir
Neuraminidase inhibitor that reduces the amount of virus in the body by inhibit the enzyme that releases NEW viral particles

**MUST use within 48 hours

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9
Q

Baloxavir
(Xofluza)

A

used for treatment and post exposure prevention of influenza
endonuclease inhibitor

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10
Q

Zovirax

A

Acyclovir
blocks DNA synethesis and viral replication by incorporating into viral DNA

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11
Q

Valtrex

A

Valacyclovir
prodrug of acyclovir - blocks DNA synethesis and viral replication by incorporating into viral DNA

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12
Q

Ganciclovir

A

blocks DNA synethesis and viral replication by incorporating into viral DNA

Treatment of Cytomegalovirus

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13
Q

Valcyte

A

Valganciclovir
blocks DNA synethesis and viral replication by incorporating into viral DNA

Treatment of Cytomegalovirus

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14
Q

Mavyret

A

Glecaprevir - NS3/4A protease inhibitors
Pibrentasvir - NS5A Replication Complex inhibitor

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15
Q

Epclusa

A

Sofosbuvir - NS5B Polymerase inhibitor

Velpatasvir - NS5A Replication Complex inhibitor

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16
Q

Dasabuvir

A

NS5B Polymerase inhibitor

17
Q

Grazoprevir

A

NS3/4A - Protease inhibitor

18
Q

Elbasvir

A

NS5A Replication Complex inhibitor

19
Q

Ledipasvir

A

NS5A Replication Complex inhibitor

20
Q

Ombitasvir

A

NS5A Replication Complex inhibitor

21
Q

Paritaprevir

A

NS3/4A protease inhibitor

22
Q

Voxilaprevir

A

NS3/4A protease inhibitor

23
Q

Viread

A

TDF
NRTI - inhibits HBV replication

MONOTHERAPY for HBV

24
Q

Vemlidy

A

TAF
NRTI - inhibits HBV replication

Monotherapy for HBV

25
Q

Baraclude

A

Entecavir
NRTI - inhibits HBV replication

*preferred therapy for HBV

26
Q

Interferon Alfa

A

cytokine that have antiviral, antiproliferative, and immunomodulatory effects

pegylated formulation has increased half life

treatment for HBV or HCV

27
Q

Ribavirin

A

inhibits the replication of RNA and DNA of viruses - used ONLY for HCV but NOT monotherapy

Antifungal + Antivirals (4 decks)

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