Mechanism of action Flashcards by Frida Bostrøm

Q

Penicillins

A

Inhibition of cell wall synthesis

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Q

Beta-lactamase-inhibitors

A

inhibition of cell wall synthesis

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Q

Cephalosporins

A

inhibition of cell wall synthesis

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Q

Carbapenems

A

inhibition of cell wall synthesis

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Q

Monobactams

A

inhibition of cell wall synthesis

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Q

Aminoglycosides

A

inhibition of protein synthesis (30S subunit), mistranslation

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Q

Tetracyclines

A

inhibition of protein synthesis (30S subunit)

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Q

Spectinomycin

A

Bacteriostatic

Inhibition of protein synthesis (30S subunit)

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Q

Macrolides

A

Bacteriostatic

inhibition of protein synthesis (50S subunit)

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Q

Lincosamides

A

Bacteriostatic

inhibition of protein synthesis (50S subunit)

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Q

Pleuromutilins

A

Bacteriostatic

inhibition of protein synthesis (50S subunit)

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Q

Phenicols

A

Bacteriostatic

inhibition of protein synthesis (50S subunit)

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Q

Polypeptide antibiotics

A

Concentration dependent bactericidal

They act like a cationic detergent

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Q

Glycopeptide antibiotics

A

time dependent bactericidal

inhibition of cell wall synthesis

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Q

Rifamycines

rifampicin

A

time dependent bact.

inhibit bacterial DNA-dependent RNA polymerase

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Q

Pseudomonic acid

-mupirocin

A

bactericidal

inhibition of cell wall synthesis

Q

Phosphonic acid derivates

-fosfomycin

A

bactericidal

inhibition of cell wall synthesis

Q

Fusidic acid

A

bacteriostatic

inhibition of protein synthesis

Q

Sulphonamides

A

bacteriostatic

inhibition of folic acid synthesis

Q

Diaminopyrimidines

A

bacteriostatic

inhibition of folic acid synthesis

Q

sulfamethoxasole + trimethoprim/ baquiloprim

A

time dependent bactericidal

inhibition of folic acid synthesis

Q

sulfadiazine + trimethoprim/baquiloprim

A

time dependent bactericidal

inhibition of folic acid synthesis

Q

Fluoroquinolones

A

concentration dependent bactericidal

inhibition of DNA synthesis

Q

Nitrofurans

nitrofurantoin
furazolidone

A

bactericidal

destroy the DNA of bacteria

Q

Nitroimidazoles

metronidazole
ronidazole
tinidazole

A

concentration dependent bactericidal

destroy the DNA of bacteria