Mechanism/Drug Class Flashcards by Melissa V | Brainscape

Q

What is the mechanism of action of the inhibitors of catecholamine synthesis?

A

Inhibit tyrosine hydroxylase, the rate-limiting enzyme in the catecholamine biosynthesis pathway

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Q

α-methyltyrosine

A

inhibitor of catecholamine synthesis

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Q

What is the mechanism of action of the inhibitors of catecholamine storage?

A

Inhibit catecholamine storage in vesicles, resulting in short-term increase in release of catecholamines from the synaptic terminal but long-term depletion of available pool of catecholamines

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Q

reserpine

A

inhibitor of catecholamine storage

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Q

guanethidine

A

inhibitor of catecholamine storage

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Q

guanadrel

A

inhibitor of catecholamine storage

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Q

amphetamine

A

inhibitor of catecholamine storage

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Q

methylphenidate

A

inhibitor of catecholamine storage

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Q

pseudoephedrine

A

inhibitor of catecholamine storage

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Q

What is the mechanism of action of the inhibitors of catecholamine reuptake?

A

Inhibit norepinephrine transporter (NET)-mediated reuptake of catecholamines, potentiating catecholamine action

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Q

cocaine

A

Inhibitor of catecholamine reuptake

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Q

imipramine

A

Inhibitor of catecholamine reuptake

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Q

amitriptyline

A

Inhibitor of catecholamine reuptake

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Q

What is the mechanism of action of MAO inhibitors?

A

Inhibit MAO, increasing catecholamine levels by blocking catecholamine degradation

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Q

phenelzine

A

Nonselective MAO inhibitor

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Q

iproniazid

A

Nonselective MAO inhibitor

Q

tranylcypromaine

A

Nonselective MAO inhibitor

Q

clorgyline

A

MAO-A inhibitor

Q

brofaromine

A

MAO-A inhibitor

Q

befloxatone

A

MAO-A inhibitor

Q

moclobemide

A

MAO-A inhibitor

Q

selegiline

A

MAO-B inhibitor