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Cancer > Mech > Flashcards

Mech Flashcards

1
Q

Drug Name

A

Mechanism

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2
Q

Cyclophosphamide, Melphalan, Chlorambucil

A

Forms covalent bonds to DNA, crosslinking strands and inhibiting DNA synthesis/transcription.

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3
Q

Carmustine (BCNU), Lomustine (CCNU)

A

Forms DNA crosslinks, inhibiting DNA replication and transcription.

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4
Q

Procarbazine, Dacarbazine

A

Alkylates DNA, leading to breaks in DNA strands.

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5
Q

Busulfan

A

Induces DNA crosslinks, halting DNA replication and transcription.

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6
Q

Cisplatin, Carboplatin, Oxaliplatin

A

Forms intrastrand and interstrand DNA crosslinks, inhibiting DNA synthesis.

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7
Q

Methotrexate (MTX)

A

Inhibits dihydrofolate reductase, blocking purine and thymidylate synthesis.

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8
Q

5-Fluorouracil (5-FU), Capecitabine

A

Inhibits thymidine synthesis and incorporates into DNA/RNA as a false nucleotide.

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9
Q

Cytarabine, Gemcitabine

A

Incorporates into DNA as a false nucleotide, inhibiting DNA polymerase and ribonucleotide reductase.

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10
Q

6-Mercaptopurine (6-MP)

A

Inhibits purine synthesis and incorporates false nucleotides into DNA/RNA.

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11
Q

Fludarabine, Cladribine

A

Inhibits DNA synthesis by disrupting purine nucleotide metabolism.

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12
Q

Vinblastine, Vincristine, Vinorelbine

A

Inhibits tubulin polymerization, disrupting microtubule assembly.

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13
Q

Paclitaxel, Docetaxel

A

Stabilizes microtubules, inhibiting their disassembly.

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14
Q

Etoposide

A

Inhibits topoisomerase II, preventing DNA strand religation.

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15
Q

Topotecan, Irinotecan

A

Inhibits topoisomerase I, preventing DNA single-strand breaks from being repaired.

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16
Q

Doxorubicin, Epirubicin, Daunorubicin

A

Intercalates into DNA, generates oxygen free radicals, and inhibits topoisomerase II.

17
Q

Asparaginase

A

Hydrolyzes L-asparagine, inhibiting protein synthesis.

18
Q

Hydroxyurea

A

Inhibits ribonucleotide reductase, depleting DNA precursors. S phase

Cancer (4 decks)

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