Mec Of Action

Question 1

Triptans

Answer 1

5 HT1D agonist

Question 2

SSRI

Answer 2

Inhibits serotonin transporter in the pre-synaptic neuron - decreases serotonin reuptake in the synaptic cleft

Question 3

SNRI

Answer 3

Decreases 5-HT and NE reuptake

Question 4

Bupropion

Answer 4

Inhibits NE and DA reuptake

Question 5

Mirtazapine

Answer 5

• alfa-2 pre-synaptic antagonist- increases 5HT, DA, and NE (main therapeutic effect)
• inhibits 5-HT2 and 5-HT3 - improves sexual and GI side effects
• inhibits H1 - sedation
• noradrenergic alpha-1 antag - orthostasis

Question 6

MAOIs

Answer 6

Inhibits MAO - increases 5-HT, DA, and NE

!! Unknown why it can cause orthostatic hypotension.

Question 7

SGA

Answer 7

• antag D2

- antag 5-HT 2A

Question 8

Amphetamine

Answer 8

• increases release of DA and NE from the pre-synaptic vesicles
• inhibits DA and NE reuptake
• inhibits MAOI

All of them increase activity of DA and NE

Question 9

Buprenorphine

Answer 9

• partial opioid agonist at mu receptor

- opioid antag at the kappa receptor

Question 10

Clonidine, guanfacine, lofexidine

Answer 10

Alfa 2 agonists - decrease 5-HT , DA , and NE

Question 11

Donepezil, galantamine, rivastigmine

Answer 11

ACh-esterase inhibitors - increases ACh activity

• rivastigmine: + butyryl-cholinesterase (BChE) inhibitor
• galantamine: + potentiates nicotinic receptor agonists

Question 12

Memantine

Answer 12

• antag at NMDA receptor

- antag 5-HT3

Question 13

Prazosin

Answer 13

Alpha 1 antagonist

Question 14

Aripiprazole

Answer 14

• partial agonist at D2 (instead of antag)
• partial agonist at 5-HT 1A
• antag at 5-HT 2A

Question 15

Ziprazidone

Answer 15

• antag D2

- week SSRI effect