Measles, Mumps and Rubella

Question 1

Measles is also know as?

Answer 1

Rubeola

Question 2

Measles is only endemic in nature. T/F

Answer 2

False
It is both epidemic and endemic

Question 3

The 2 most important virulent proteins in measles virus are?

Answer 3

Haemagglutinin protein
Fusion protein

Question 4

Function of virulent factors of measles virus

Answer 4

Haemagglutinin is responsible for binding of virus to the cells

Fusion protein is responsible for fusion of virus and host cell membrane , penetration of virus, and hemolysis

Question 5

CD150 are receptors on which type of cells

Answer 5

Immune cells(B and T cells)

Question 6

Signaling Lymphocytes Activation Molecules (SLAM) are found on which cells?

Answer 6

CD150(SLAM) are found on immune cells(B and T cells)

Question 7

Incubation period of measles?

Answer 7

7-14 days with an average of 10-12 days

Question 8

The first sign of measles is usually? And lasts for?

Answer 8

High fever(40•C) that last for 4-7 days

Question 9

The prodromal phase of measles is marked by?

Answer 9

Malaise, fever, anorexia and the classic triad of Conjunctivitis, cough and coryza(3Cs)

Question 10

Measles has an epidemic cycle of how many years

Answer 10

2-3

Question 11

Measles transmission is regulated by?

Answer 11

Herd immunity

Question 12

Treatment of measles is essentially via?

Answer 12

Supportive therapy

Question 13

Rubella is AKA

Answer 13

German measles or 3-day measles

Question 14

The nucleocapsid of rubella virus is composed of?

Answer 14

Polypeptide (C protein) and a single stranded RNA

Question 15

The outer envelope of Rubella virus is composed of?

Answer 15

Glycosylated lipoprotein (which contains 2 virus specific polypeptides- (E1 and E2) and a host cell derived lipid

Question 16

Rubella virus is resistant to?

Answer 16

Thimerosal

Question 17

Incubation period for rubella?

Answer 17

14-21 days after exposure to a person with the virus

Question 18

Eye pain on lateral and upward eye movement is a complaint associated with?

Answer 18

Rubella viral infection

Question 19

Lab diagnosis of rubella can be made via 2 means, namely?

Answer 19

Serologic testing
Viral culture

Question 20

Mumps is caused by mumps virus, which is AKA?

Answer 20

Rubula virus

Question 21

A secondary phase of viremia that occurs in mumps infection is due to?

Answer 21

Replication of the virus at target organs such as salivary glands(parotid) and extra-salivary locations (CNS)