Measles

Question 1

Measles is extremely contagious but also

Answer 1

LABILE

Question 2

Measles is extremely contagious but also

Answer 2

LABILE

Question 3

All members of the paramyxoviridae family initiate infection via wha tract

Answer 3

Respiratory

Question 4

Morphology of measles

Answer 4

Pleommorphic

Question 5

Genome of measles:

Answer 5

Enveloped, linear, negative-sense, non-segmented ssRNA

Question 6

Is non-segmented, negates opportunity for frequent genetic reassortment , which makes the virus antigenically

Answer 6

STABLE

Question 7

VIRAL RNA PROTEINS (3)

Answer 7

1. NUCLEOPROTEIN (N)
2. P
3. L
   P and L for viral polymerase activity: transcription and translation

Question 8

VIRAL ENVELOPE PROTEINS (3)

Answer 8

1. M (MATRIX)- VIRAL ENVELOPE (with spikes); Viral assembly
2. HN OR G- ATTACHMENT
   ; Hemagglutination or Neuraminidase activity
3. Fusion (F)- Fusion and Hemolysin activity

Question 9

Receptors used for infection:

Answer 9

CDD46 and CD150
CD46- present on all nucleated cells
CD150- (SLAM) Signaling Lymphocyte Activation MOLECULE

Question 10

Infects E cells in what organ?

Answer 10

Trachea and Bronchi

Question 11

Body organs migration of Measles

Answer 11

From local tissue in the lungs →
local lymph nodes → blood →more
long tissues -intestines and brain

Question 12

Incubation Period

Answer 12

10-14
8-15

Question 13

Prodromal period lasts for and is accompanied by the following symptoms:

Answer 13

FCCC
Fever
Cough
Coryza (stuffy face)
Conjunctivitis
and Koplik spot’s (pathognomonic)

Question 14

Small, bluish-white, with cessations, found inside the cheeks (enanthem), and is pathognomonic for measles

Answer 14

Koplik’s Spots

Question 15

Induces intranuclear inclusions which are multinucleated giant cells with viral antigens, it is formed as a result of the fusion protein in the spikes

Answer 15

WARTHIN-FINKELDAY

Question 16

Hemagglutinin +
Neuraminidase -
Fusion Protein +

Answer 16

Measles
Hemagglutinin: binds sialic acid and promotes viral entry
Neuraminidase: promotes vision progeny release

Question 17

On what day does the maculopapular rash appear?

Answer 17

Day 15, Abs become detectable and viremia disappears. (Result of interaction of Immune T-Cells with virus infected cells.

Question 18

Complications:

Answer 18

1. Otitis media
2. Giant Cells Pneumonia
3. CNS complication (most serious)
4. Post-Infectious Encephamyolitis
5. SSPE/DAWSON DISEASE

Question 19

LAB DIAGNOSIS- GOLD STANDARD

Answer 19

Viral Culture Method