MDD REVIEW

Question 0

The STAR*D study is a landmark clinical trial that utilized a unique study design intended to replicate real-world clinical practice. which of the following are among the findings or conclusions of this study?

(3 things)

Answer 0

1. Remission can take a long time over three months in some cases
2. Most patients did not achieve remission with the first level of treatment
3. There were no clinical statistical differences in remission rates among the different medications used in the study

Question 1

Which of the following are believed to be the primary psychological targets of the five major antidepressant classes and thought to be responsible for their pharmacologic effects?

(3 things)

Answer 1

1. Serotonin transporter (SERT)
2. Nor epinephrine transporter (NET)
3. Monoamine oxidase MAOI

Question 2

Serotonin syndrome is most severe when SNRIs are administered with which of these antidepressant classes

Answer 2

MAOIs

Question 3

In 2004 the FDA conducted a full review of published and unpublished clinical trials of antidepressants in response to reports of suicidal thoughts and actions in children and adolescents. what are some of the conclusions and outcomes of the review
(2 things)

Answer 3

1. Some children experienced suicidal thinking or behavior

2. The FDA decided to include a boxed warning and label on all antidepressants

Question 4

During MDD treatment patients sometimes do not show any signs of improvement and need a change in their therapeutic regimen. which of the following situations should a physician avoid?

Answer 4

Combining SSRI treatment with MAOIs

Question 5

Which of the following statements are not true regarding SNRIs

(2 things)

Answer 5

1. Studies have consistently shown that SNRIs are more effective than SSRIs and all MDD patients
2. Unlike SSRIs, SNRIs generally do not have therapeutic lag

Question 6

Serotonin syndrome is most severe when SNRIs are administered with which of these antidepressant classes?

Answer 6

Another SNRI

Question 7

Which of the following antidepressants were developed in the 1950s?

(2 things)

Answer 7

1. TCAs

2. MAOIs

Question 8

Significant elevation in blood-pressure may occur when a patient taking an ___ ingests large amounts of tyramine contained either in food or medication

Answer 8

MAOI

Question 9

What causes serotonin syndrome?

Answer 9

An excess of serotonin stimulation in the brain that can cause life-threatening symptoms

Question 10

Which was the first FDA approved SSRI

Answer 10

Prozac (fluoxetine)

Question 11

Which statement below is applicable to TCAs in terms of safety?

Answer 11

TCAs can potentially cause cardiovascular side effects

Question 12

Which of the following has the highest risk of lethal overdose

Answer 12

TCAs

Question 13

The period of time after taking a medication with no measurable beneficial outcome is known as

Answer 13

Therapeutic lag

Question 14

Which treatment phase begins when symptoms are first noticed in treatment is initiated

Answer 14

Acute

Question 15

While all prescribers are different what is the number one factor that physician say they take into consideration when prescribing antidepressants ?

Answer 15

Established efficacy, physicians believe some antidepressants are more effective than others

Question 16

Which of the following are among the first line treatment options recommended by the APA

(2 things)

Answer 16

SNRIs

Welbutrin (buproprion)

Question 17

Adding another treatment to assist with the primary treatment is known as

Answer 17

Adjunctive therapy

Question 18

The patient should not abruptly stop antidepressant use after extended therapy otherwise he or she could possibly face a variety of symptoms headache, chills, body ache, insomnia, electric shocklike pneumonia, this is known as?

Answer 18

Discontinuation syndrome

Question 19

How is Wellbutrin thought to work?

Answer 19

It weekly inhibits the neuronal reuptake of norepinephrine and dopamine

Question 20

What medication was used as a first-line treatment in the STARD*D study?

Answer 20

Celexa (citalopram)