MD2001 Flashcards
Oestradiol
Oestrogen
Where is the FSH and LH produced
Anterior Pituitary Glands
What are the 2 places in the hypothalamus that is responsible for ovarian control
Preoptic nucleus
Supraoptic nucleus
GnRH (6 features)
Produced in both males and females in the hypothalamus
Released as prohormone
Modified to active form
Secreted to hypophyseal portal system
Pulsatile
Delivered via hypophyseal portal circulation to anterior pituitary gonadotrobes via veins
Benefits of pulsatile hormones (3 features)
Low energy
Does not desensitise tissue receptors
Stress and other substances could influence the secretion of it
Function of ovaries (2)
Houses oocytes
Contains follicles in various stages of development
Stages of development of oocytes
Premordial Primary (has no theca cells; has granulose cells) Secondary Tertiary Graafin follicles
Theca cells (4)
Superficial layer
Has LH receptors
Changes cholesterol into pregnenolone
Produces androstenedione and testosterone
Granulosa cells
Deep layer
Layer increases in size during evelopment
Has LH and FSH receptors
Conert cholesterol into pregnenolone and activate aromatsa
Theca cells form testosterone and andestenodione
Donates them to granulose cells
FSH activate aromatase
Binds with androstenedione to form oestrogen
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Types of oestrogen
Oestradiol
Oestrone
Oestriole
Functions of oestrogen on bones
Increases bone growth
Oestrogen on endocrine system
Increase progesterone
Oestrogen on liver
Increases clotting factor
Increases HDL
Increases steroid binding proteins
Decreases LDL
Oestrogen on reproductive organs
Increases uterine growth
Increases vaginal and Fallopian tube growth
Increases breast growth
Increases cervical mucus
Increases LH receptors on granulose cells
Secretion regulation of oestrogen
- Mid shift from negative to positive feedback, caused by changes of receptors (GnRH in anterior pituitary when oestrogen level is high)
2, Results in LH and FSH production before ovulation