MD2001 Flashcards

1
Q

Oestradiol

A

Oestrogen

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2
Q

Where is the FSH and LH produced

A

Anterior Pituitary Glands

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3
Q

What are the 2 places in the hypothalamus that is responsible for ovarian control

A

Preoptic nucleus

Supraoptic nucleus

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4
Q

GnRH (6 features)

A

Produced in both males and females in the hypothalamus
Released as prohormone
Modified to active form
Secreted to hypophyseal portal system
Pulsatile
Delivered via hypophyseal portal circulation to anterior pituitary gonadotrobes via veins

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5
Q

Benefits of pulsatile hormones (3 features)

A

Low energy
Does not desensitise tissue receptors
Stress and other substances could influence the secretion of it

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6
Q

Function of ovaries (2)

A

Houses oocytes

Contains follicles in various stages of development

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7
Q

Stages of development of oocytes

A
Premordial
Primary (has no theca cells; has granulose cells)
Secondary
Tertiary
Graafin follicles
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8
Q

Theca cells (4)

A

Superficial layer
Has LH receptors
Changes cholesterol into pregnenolone
Produces androstenedione and testosterone

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9
Q

Granulosa cells

A

Deep layer
Layer increases in size during evelopment
Has LH and FSH receptors
Conert cholesterol into pregnenolone and activate aromatsa

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10
Q

Theca cells form testosterone and andestenodione
Donates them to granulose cells
FSH activate aromatase
Binds with androstenedione to form oestrogen

A

-

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11
Q

Types of oestrogen

A

Oestradiol
Oestrone
Oestriole

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12
Q

Functions of oestrogen on bones

A

Increases bone growth

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13
Q

Oestrogen on endocrine system

A

Increase progesterone

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14
Q

Oestrogen on liver

A

Increases clotting factor
Increases HDL
Increases steroid binding proteins
Decreases LDL

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15
Q

Oestrogen on reproductive organs

A

Increases uterine growth
Increases vaginal and Fallopian tube growth
Increases breast growth
Increases cervical mucus
Increases LH receptors on granulose cells

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16
Q

Secretion regulation of oestrogen

A
  1. Mid shift from negative to positive feedback, caused by changes of receptors (GnRH in anterior pituitary when oestrogen level is high)
    2, Results in LH and FSH production before ovulation
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17
Q

Progestins

A

Progesterones
Produced in theca cells and granulose cells
Short half life (5 mins)
Regulation is linked to oestrogen
Develop materials to make milk but inhibit the production of milk

18
Q

Menstrual cycle

A

Ovarian cycle + endometrial cycle

19
Q

Ovarian cycle

A

Follicular phase

Luteal phase

20
Q

Follicular phase

A

Due to the mature of Graafin follicles/secondary oocytes

21
Q

Luteal phase

A

Dominated by corpus luteum
- Synthesise/secrete oestrogen and progesterone for implantation/maintenance of fertilised eggs
Corpus luteum regress and degenerates 10-12 days if no fertilisation

22
Q

Endometrial cycle

A

Proliferative phase
Secretory phase
Menstruation

23
Q

Proliferative phase

A

Endometrial growth due to increase of oestrogen
Blood vessel and gland growth occurs
Ovulation = end of phase

24
Q

Secretory phase

A

Maturation but no growth of endometrium due to low level of oestrogen
Mucus glands fully develop
Glands and blood vessels increases surface area

25
Q

Menstruation

A

If no conception, endometrial lining replaced

  • Vasoconstriction of spiral arteries
  • Local ischaemic injury
  • Inflammatory cell infiltration
26
Q

Lactation

A

Milk production and secretion

27
Q

Mammary glands

A

Breast tissue prepared during puberty via female gonadal hormones

28
Q

Development in pregnancy

A
Oestrogen
Progestins
- Prepares breast for milk production, but no milk is produced
HcG from foetus
Prolactin for milk production
29
Q

Oxytocin

A

Let down milk

30
Q

Follicular phase and luteal phase split by ovulation

A

-

31
Q

Corpus luteum

A

What oocytes leave behind after ovulated
Stimulates production of hormones
Degenerates if fertilisation does not occur

32
Q

Lydia cells

A

Produces testosterone

33
Q

Testis

A

Contains:
Leydig cells
Blood vessels
Seminiferous tubules (produces sperm and house Sertoli cells)

34
Q

Spermatogenesis

A
Spermatogonia
Primary spermatocytes
Secondary spermatocytes
Spermatids
Spermatozoa
35
Q

Testosterone

A

Regulates spermatogenesis
Increase bone growth
Increases muscle and connective tissue
Increases size of testes, prostate, seminal vesicles and penis
Increase facial, axillary and pubic hair
Increases size of larynx
Increases sebaceous gland size and secretion

36
Q

Testosterone secretion regulattyion

A

Pathway similar to ovaries except:

  • Only 1 primary hormone (progesterone) vs. 2 primary hormone (oestrogen & progestins)
  • No roles of acting established
37
Q

Progestin

A
  • Aids in conversion of endometrial cycling from proliferative to secretory phase
  • Responsible for increase of body temperature in luteal phase of ovarian cycle
38
Q

Negative feedback anterior pituitary in females

A

Oestrogen, progestins and inhibins

39
Q

Positive feedback anterior pituitary in females

A

Activins

40
Q

Negative feedback anterior pituitary in males

A

Testosterone and inhibins B

41
Q

Negative feedback hypothalamus in males

A

Testosterone

42
Q

Testosterone and dihydrotestosterone

A
Embryonic development of male genitals
Accessory organs
Growth of genitals; hairs
Spermatogenesis
Anabolic effects of musculoskeletal system