MCQs

Question 1

Which cell in cancer is not affected by radiation?

Answer 1

Muscle cells

Question 2

Name an example of a tumour suppressor gene.

Answer 2

APC

TP53

Question 3

Dysfunction in cell receptors to anti-growth signals is which hallmark of cancer?

Answer 3

Unresponsiveness to growth-inhibitory signals

Question 4

VEGF causes endothelial cells to migrate and proliferation into new blood vessels and what hallmark is this?

Answer 4

Sustained angiogenesis

Question 5

G2 and M phase are to identify double strand breaks in DNA. What is there when the cell cycle continues?

Answer 5

Cell cycle adaptation leading to genomic aberration

Question 6

Which oncogene is involved in T(14:18) follicular lymphoma?

Answer 6

Bcr-abl

Question 7

What causes Trastuzumab resistance in HER2?

Answer 7

Resistance occurs when there is a change in the extracellular domain of the receptor resulting in truncation of the HER2 receptor

Question 8

What is the last stage of a tumour?

Answer 8

Distant metastasis (beyond regional lymph nodes)

Question 9

What word describes when a cell has completely lost morphological features?

Answer 9

Anaplasia

Question 10

What happens when a cell can produce telomerase?

Answer 10

Limitless reproductive potential

Question 11

What happens when APC is inactivated?

Answer 11

Hyperplasia for adenomatous cells