MCQ Flashcards
C: Which of the following answers is correct?
1) The NOAEL is defined as the highest dose at which no clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies
2) The NOAEL is defined as the lowest dose at which at least one clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies
The NOAEL is defined as the highest dose at which no clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies
C: The primary outcome of a First-in-Human study is always
1) Safety and tolerability
2) feasability
3) Pharamcodynamics
4) Therapeutic effect
Safety and tolerability
Which brain function is dominated most by one hemisphere?
Language
P: Which of the following imaging patterns has been shown to reliably identify patients whose symptoms began no more than 4.5 hours prior to imaging?
1) Positive lesion on DWI and negative lesion on FLAIR
2) Positive lesion on DWI and positive lesion on perfusion imaging
3) Negative lesion on DWI and positive lesion on FLAIR
4) Negative lesion on DWI and positive lesion on perfusion imaging
5) Positive lesion on DWI and vessel occlusion on MRA
Positive lesion on DWI and negative lesion on FLAIR
G: Which of the following statements is right?
Pharming is the breeding of transgenic disease models.
Pharming has nothing to do with genetic manipulation.
Pharming refers to the production of recombinant proteins in livestock
The most efficient livestock for pharming is cattle.
Pharming refers to the production of drug-free meat.
Pharming is the breeding of transgenic disease models
G: To analyse a cell-type specific knockout you need
a transgenic mouse strain harboring a cell type-specific Cre transgene
a transgenic mouse strain harboring a “floxed” allele
a facility for zygote injection
a facility for embryonic stem cell culture
a means to detect your gene product of choice
a transgenic mouse strain harboring a cell type-specific Cre transgene
a transgenic mouse strain harboring a “floxed” allele
a means to detect your gene product of choice
What are the legal preconditions for the conduct of a clinical study?
IRB approval
Insurance Certificate
Data protection approval
Youth welfare office approval
Study bank account
IRB approval
Insurance Certificate
Data protection approval
C: Which study(ies) belong(s) to Phase I? Bioequivalence First in Human Pharmacokinetics in renal impairment Proof of concept Pharmacokinetic drug interaction
Bioequivalence
First in Human
Pharmacokinetics in renal impairment
Pharmacokinetic drug interaction
P: Which of the following is NOT an early sign of brain ischemia on computed tomography (CT)? Hyperdense artery sign Dural tail sign Insular ribbon sign Effacement of the sulci Loss of the lentiform nucleus
Dural tail sign
G: Embryonic stem cells are
forming the trophoectoderm of an embryo
maintained in culture in the absence of LIF
derived from the trophoectoderm of an embryo
needed for pronucleus injection
derived from the inner cell mass of a blastocyst
derived from the inner cell mass of a blastocyst
P: Which is true?
The main role of MR angiography (MRA) is for visualizing the ischemic penumbra
Intravenous thrombolysis is indicated up to 9 hours following stroke symptom onset in Europe
The abundance of collateral flow has a generally detrimental effect on stroke outcome
“Time shift analysis” measures perfusion by tracking a bolus of intravenously injected Gadolinium
Longer thrombi are associated with less successful recanalization after thrombolysis
Longer thrombi are associated with less successful recanalization after thrombolysis
