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NPC MCQ > MCQ > Flashcards

MCQ Flashcards

1
Q

Dopamine structure

A
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2
Q

Noradrenaline structure

A
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3
Q

Acetylcholine structure

A
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4
Q

5HT structure

A
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5
Q
  1. Which of these neurotransmitter pathways are well established dopaminergic tracts?
A

A. Nigrostriatal pathway
C. Mesocortical pathway

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6
Q
  1. The Raphe Nucleii are in the cerebellum
    True
    False
A

False

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7
Q
  1. Insight into the neuropathology of psychiatric disorders can be obtained by analyses of postmortem brain. The data obtained must be treated with caution because
A
  • Drug treatments can cause long term changes to the neurochemistry of the brain
  • The medical history of the patient immediately prior to death can affect the lability of receptor and other proteins in the brain
  • The expression levels of neurotransmitter receptors is age-dependent
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8
Q
  1. The medial forebrain bundle consists of
A

Dopaminergic axons
Noradrenergic axons
Serotonergic axons

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9
Q
  1. Which of the following regions of the brain harbour dopaminergic neurones?
A

The ventral tegmental area
The substantia nigra
The arcuate nucleus

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10
Q
  1. Match the brain region to the functional role it is most associated with amygdala
A

Aversive Learning

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11
Q

Frontal lobe

A

Decision making

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12
Q

Thalamus

A

Relay station

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13
Q

Reticular activating system

A

Arousal

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14
Q
  1. Glutamate is a major inhibitory neurotransmitter in the brain
    True
    False
A

False

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15
Q
  1. GABA is a major inhibitory neurotransmitter in the brain
    True
    False
A

True

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16
Q
  1. Which of the following is a catecholamine?
A

Adrenaline
Dopamine

17
Q
  1. Which combination of drugs could you expect to see cross tolerance with in human subjects?
A
  1. LSD and mescaline
18
Q
  1. In the drug discrimination task, which two drugs would a rat be predicted not to be able to discriminate?
A

LSD and mescaline

19
Q
  1. Which of the following provides evidence that LSD acts as a 5HT2 receptor agonist?
A

LSD decreases 5HT turnover in rat brain

20
Q
  1. Which of the following provides evidence that the reinforcing properties of cocaine are mediated by its blockade of the presynaptic high affinity dopamine transporter (DAT) in the brain?
A

transgenic mice expressing cocaine insensitive DAT do not show conditioned placed preference for cocaine when conditioned with cocaine versus saline

21
Q
  1. What kind of signalling molecule is corticotrophin releasing factor (CRF)?
A

Neuropeptide

22
Q
  1. Which of these drugs increase dopamine release in the nucleus accumbens? Tick all that are correct.
A

Ethanol
Nicotine
Morphine

23
Q
  1. Which of the following statements about the medial forebrain bundle is correct? Tick all the correct statements.
A
  • The medial forebrain bundle consists of dopaminergic, noradrenergic and serotonergic projections.
  • Electrical stimulation of the medial forebrain bundle causes reinforcement behaviour in rats.
24
Q
  1. Which of the following best describe the effect of activity in the mesolimbic projection from the ventral tegmental area to the nucleus accumbens on cortical activity?
A

disinhibition

25
Q
  1. Polymorphisms in the mu opiate receptor have been identified as a risk factor for alcohol use disorder. This may be explained by the observation that mu opiate receptors are expressed on ……. interneurons in the ventral tegmental area. Mu receptors ……. GABA release and ………. activity in the ……. mesolimbic pathway.
A

GABA
inhibit
increase
dopamine .

26
Q
  1. You are researching the mode of action of a novel psychoactive substance (NPS) for your PhD thesis. Which of the following would provide the best evidence that it shares a similar mode of action to amphetamine?
A

In radioligand binding studies NPS is shown to bind with high affinity to the presynaptic dopamine transporter DAT

27
Q
  1. Which of the following complex psychiatric disorders would be classified as a pervasive developmental disorder?
A
  1. Autism
  2. Schizophrenia
  3. Rett’s Syndrome
28
Q

Which of the following is likely to indicate an underpinning mechanism that leads to expression of neuroatypical behaviours associated with autism?

A
  • An increase in excitability associated with epileptic seizures
  • A decrease in neuronal cell death associated with epileptic seizures
  • A change in the axon growth mechanism that occurs during synaptic connectivity
  • An increase in neuronal cell size and reduced neuronal cell density
29
Q
  • Neuroligin belongs to a family of ………. proteins that organize postsynaptic scaffolds. They achieve connectivity with the presynapse via an important ……. binding to members of the …….. multigene family.
A

Neuroligin belongs to a family of adhesion proteins that organize postsynaptic scaffolds. They achieve connectivity with the presynapse via an important transynaptic binding to members of the neurexin multigene family.

30
Q
  1. Which of the following would you define as a DSM V defined inclusion criteria in the definition of depression?
A

Weight loss when not dieting.
Insomnia
Hypersomnia

31
Q
  1. Which of the following drugs would directly affect the synaptic levels of dopamine in the brain?
A

Imipramine
Cocaine
Reserpine

32
Q
  1. Which of the following statements concerning the plasma membrane serotonin transporter is true?
A
  1. Fluoxetine competes with serotonin and the transporter substrate binding site
  2. It uses Na+ and Cl- ions to facilitate the re-uptake of synaptic serotonin.
  3. It contains a central pairing of transmembrane helix 1 and 6 to contribute to the substrate binding site
33
Q
  1. Which of these statements best describes the interaction between monoamineoxidase inhibitors, MAOI, and tyramine?
A

MAOI potentiate the sympathomimetic action of tyramine

34
Q
  1. Stress can induce a sustained level of glucocorticoids leading to biological changes that are associated with depression. Which of the following SSRI induced phenomenon might reverse some of the deleterious impacts of stress that underpin depression?
A

Chronic synaptogenesis and neurogenesis
Induction of neurotrophic signalling as part of chronic changes in brain signalling

35
Q
  1. Which of the following statements best describes the pharmacological basis for extrapyramidal syndromes during treatment with typical antipsychotic drugs?
A

Typical antipsychotics block D2 dopamine receptors in the nigrostriatal pathway

36
Q
  1. Which of these experimental results provide evidence that the reinforcing properties of cocaine are due to blockage of the high affinity plasma membrane dopamine transporter, DAT?
A

Cocaine does not cause conditioned place preference in mice expressing a cocaine insensitive DAT.

NPC MCQ (1 decks)

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