MCQ Flashcards

1
Q

What is the amount of blood, on supine

  • Systemic circulation?
  • Capillaries?
  • Heart?
A
  • 75%
  • 5%
  • 8%
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2
Q

What is the main determinant of gastric emptying?

A

antral pump activity

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3
Q

How does indocyanine green work for liver blood flow measurement

A

Indocyanine green

  • Constant infusion 20 mins to achieve equilibration.
  • Infusion rate = clearance rate
  • Clearance = hepatic blood flow x extraction ratio
  • Extraction ratio = Arterial - venous / arterial conc
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4
Q

What percentage of RBC is destroyed within the 24 hrs after transfusion?

A

10-20%

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5
Q

What produces vWF

A

endothelium

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6
Q

What is the most clinically significant blood group after ABO and Rh?

A

Kell

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7
Q

Blood flow rate interaction with viscosity?

A

Viscosity decreases with increased flow rate

Inversely proportional

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8
Q

What factors increase ADH?

A

high blood osmolarity - stimulates hypothalamic osmoreceptors

Decrease ECF volume 
SNS stimulation 
RAAS 
Drugs 
Hypercapnoea
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9
Q

What are the actions of ANP?

A
Increase GFR by AA dilation 
Mesangial cell relaxation 
Decrease NA/K ATPase 
Inhibit Na/Cl co-transporter in DCT 
Increase blood flow through medullary vasa recta 
Inhibit renin release
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10
Q

What is SIADH?

A

abnormally high level of ADH

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11
Q

What is bulk flow and what does it rely on?

A

process used by small lipid-insoluble proteins to cross the capillary wall

Depends on hydrostatic and oncotic pressure

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12
Q

Where is B12 absorbed?

A

terminal ileum

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13
Q

What is xanthopsia?

A

yellow vision, suggests digoxin toxicity

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14
Q

What can be measured using spectrometry?

A

Only compounds with dissimilar atoms

Cannot be used to measure N2, for example.

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15
Q

Lymph fat and protein in relation to plasma?

A

High fat, lower protein

Also significant clotting factors

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16
Q

Asepsis:

A

the prevention of microbial contamination of living tissues or sterile materials.

17
Q

Disinfection:

A

the inactivation of non-sporing organisms using either thermal or chemical means.

18
Q

Sterilisation:

A

complete destruction of all micro-organisms, including spores.

19
Q

What causes long QT syndrome?

A

Congenital
Acquired
- Drugs: antibiotics, sevo, methadone, droperidol, ondansetron
- Electrolytes: hypoMg, hyper Ca

20
Q

What is the dose of atropine to combine with neostigmine?

A

2: 1

2. 5mg neo with 1.2mg atropine

21
Q

Why would there be traces of carbon monoxide in the body ?

A

Hb breakdown from spleen generates some CO

22
Q

List the CYP450 inhibitors

A
Sodium Valproate 
Isoniazid 
Cimetidine 
Ketoconazole 
Fluconazole
Alcohol
Chloramphenicol 
Erythromycin 
Sulfonamide
Ciprofloxacin 
Omeprazole 
Metronidazole
23
Q

CYP450 inducers

A
Carbamazepine 
Rifampacin 
Alcohol 
Phenytoin 
Griseofulvin 
Phenobarbitone 
Sulphonylurea