MCM test 1 Flashcards
scurvy
- defective collagen formation
- vit C deficiency:propyl hydroxylase
- impaired wound healing, capillary hemorhage, deficient platelet, osteoblast, osteoclast function
What does anti-microtubule chemotherapy do?
- inhibits poly/depolymerization
- microtubules stable/nonfunctional=no mitosis
- taxanes, vinca alkaloids, colchcine
how do cells specialize?
expression of receptors
trophic factors
signals that keep cells alive, absence=death
what do responding cells depend on?
position w/n the gradient
what do mitogens do?
activates G1/S-Cdk to stimulate cell division
endocrine
distant sites
paracrine
nearby cells
what signals activate intracellular receptors?
steroids/NO
Where and how do steroids act?
form dimers and act on nuclear receptors, act as transcription factors and change gene expression directly
How is NO made?
NO synthase from arginine
Where and how does NO act?
only locally, acts on guanylyl cyclase which produces cGMP and nitrosylates residues on some proteins
peptide hormones
long half life and distant acting includes GH and neuropeptides
What is the effector mechanism of neurotransmitters?
- ligand-gated ion channels-change ion conc-AP
- G-protein coupled-indirectly regulate ion channels
Eicosanoids
lipids, act locally w/ short half life, induce clotting and inflammation