Math Fundamentals; Kinetic Schemes Flashcards
dC/dt
rate of change
unit: concentration/time
K
zero-order rate constant
k
First-order rate constant
A
amount
2mg = _______ mcg
2000 mcg
2ng/mL = ________ mcg/L
2mcg/L
2 mcg/mL = ________ mg/L
2mg/L
60 mL/min = ______ L/h
(60mL/min)*60/1000 = 3.5 L/h
Under zero-order kinetics, there is a constant ______ of drug being processed per unit of time.
amount (A)
First-order kinetics refers to a constant _______ of a drug being processed per unit of time
fraction
Under zero-order kinetics, the rate of change (dC/dt) is _________ drug concentration.
independent of
Zero-order rate constant has units in _________
amount/time
Under first-order kinetics, the rate of change (dC/dt) is _________ drug concentration.
proportional to
First-order rate constant has units in _______
1/time
If the elimination of a drug follows the zero-order kinetics, its elimination rate should be _______ (a constant/in proportion to the concentration)
a constant
If the elimination of a drug follows the first-order kinetics, its elimination rate should be ________ (a constant/in proportion to the concentration)
in proportion to the concentration
Under zero-order kinetics, the concentration-time profile plotted on a rectilinear graph paper should appear to be a _______ (straight line/inward curve/outward curve)
straight line
Under first-order kinetics, the concentration-time profile plotted on a rectilinear graph paper should appear to be a __________ (straight line/inward curve/outward curve)
inward curve
Under zero-order kinetics, the concentration-time profile plotted on a semi-log graph paper (with log-transformed Y-axis) should appear to be a ________ (straight line/inward curve/outward curve)
outward curve
Under first-order kinetics, the drug concentration has a ______ (linear/log-linear) relationship with time
log-linear
Linear kinetics is always the _______ order kinetics
first
Under zero-order kinetics, rate of change is _______ (proportional to/independent of) amount of drug in the body
independent of