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Virology > Masters project > Flashcards

Masters project Flashcards

1
Q

what are pro protein convertases?

A

a class of host-cell serine endoproteases

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2
Q

what is the role of PCs?

A

proteolytic events required for generating infectious microbial pathogens and for tumor growth and invasiveness

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3
Q

what is Spn4A?

A

a secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster

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4
Q

how many types of PCs do humans have?

A

7

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5
Q

how are pc’s regulated?

A

7B2, proSAAS and CRES

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6
Q

what are serpins?

A

protease inhibitors

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7
Q

how do serpins work?

A

operate as a suicide substrate inhibitor and inactivate target enzymes by using a unique ‘‘inhibition by distortion’’ mechanism

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8
Q

what is the most potent and effective endogenous serpin?

A

spn4A

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9
Q

What does spn4A do?

A

regulates PC-dependent proteolytic cleavage events in the secretory pathway of insect cells.

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10
Q

what does SDS stand for?

A

Sodium Dodecyl Sulfate

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11
Q

what does serpin regulate in Eukaryotes?

A

regulates furin activity within the secretory pathway

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Virology (3 decks)

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