MASTER MORPHOLOGY DECK Flashcards
Hernias
x
Adhesions
x
Volvulus
x
Intussusception
x
Acute Ischemic Bowel Disease
Lesions are commonly patchy
Mucosa is hemorrhagic and ulcerated
Bowel wall is thickened with edema
Transmural infarction: large portions of bowel are affected and there is a sharp line between infarct and healthy tissue –> acute vascular obstruction
Coagulative necrosis: 1-4 days after, may lead to perforation, serositis with purulent exudates and fibrin deposit
Epithelial surface sloughs off (characteristic), hyperproliferation in crypts
Chronic Ischemic Bowel Disease
Chronic: fibrous scarring of lamina propria
Radiation Enterocolitis
x
Necrotizing Enterocolitis
x
Angiodysplasia
x
Malabsorption
x
Pediatric Celiac Disease
- Biopsy of second part of duodenum or proximal jejunum are diagnostic
- Increased numbers of CD8+ T-lymphocytes, crypt hyperplasia, and villous atrophy
- Increase in the number of intraepithelial lymphocytes, particularly within the villus, is a sensitive marker of celiac disease, even in the absence of epithelial damage & villous atrophy
- However, lymphocytosis and villous atrophy are not specific; may be present in viral enteritis
- Therefore, you need both serology & histology
- IgA antibodies to tissue transglutaminase (tTG) (best) or anti-endomysial (EMA)
Adult Celiac Disease
x
Dermatitis Herpetiformis
Characteristic finding in 10% of celiac patients
Micro-abscess: papillae
Sub-epidermal blister
Granular IgA deposits
due to anti-gluten antibodies cross-reacting with BM proteins
Environmental Enteropathy
x
Autoimmune Enteropathy
x
